COVID-19 pathophysiology: Difference between revisions
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*Unlike SARS-CoV, transmission of COVID-19 takes place during the prodromal period when those infected are mildly ill and are carrying on with their usual activities. This contributes to the spread of infection.<ref name="HeymannShindo2020">{{cite journal|last1=Heymann|first1=David L|last2=Shindo|first2=Nahoko|title=COVID-19: what is next for public health?|journal=The Lancet|volume=395|issue=10224|year=2020|pages=542–545|issn=01406736|doi=10.1016/S0140-6736(20)30374-3}}</ref> | *Unlike SARS-CoV, transmission of COVID-19 takes place during the prodromal period when those infected are mildly ill and are carrying on with their usual activities. This contributes to the spread of infection.<ref name="HeymannShindo2020">{{cite journal|last1=Heymann|first1=David L|last2=Shindo|first2=Nahoko|title=COVID-19: what is next for public health?|journal=The Lancet|volume=395|issue=10224|year=2020|pages=542–545|issn=01406736|doi=10.1016/S0140-6736(20)30374-3}}</ref> | ||
*The main pathogenesis of COVID-19 is severe pneumonia, RNAemia, combined with the incidence of ground-glass opacities, and acute cardiac injury.<ref name="HuangWang2020">{{cite journal|last1=Huang|first1=Chaolin|last2=Wang|first2=Yeming|last3=Li|first3=Xingwang|last4=Ren|first4=Lili|last5=Zhao|first5=Jianping|last6=Hu|first6=Yi|last7=Zhang|first7=Li|last8=Fan|first8=Guohui|last9=Xu|first9=Jiuyang|last10=Gu|first10=Xiaoying|last11=Cheng|first11=Zhenshun|last12=Yu|first12=Ting|last13=Xia|first13=Jiaan|last14=Wei|first14=Yuan|last15=Wu|first15=Wenjuan|last16=Xie|first16=Xuelei|last17=Yin|first17=Wen|last18=Li|first18=Hui|last19=Liu|first19=Min|last20=Xiao|first20=Yan|last21=Gao|first21=Hong|last22=Guo|first22=Li|last23=Xie|first23=Jungang|last24=Wang|first24=Guangfa|last25=Jiang|first25=Rongmeng|last26=Gao|first26=Zhancheng|last27=Jin|first27=Qi|last28=Wang|first28=Jianwei|last29=Cao|first29=Bin|title=Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China|journal=The Lancet|volume=395|issue=10223|year=2020|pages=497–506|issn=01406736|doi=10.1016/S0140-6736(20)30183-5}}</ref> | *The main pathogenesis of COVID-19 is severe pneumonia, RNAemia, combined with the incidence of ground-glass opacities, and acute cardiac injury.<ref name="HuangWang2020">{{cite journal|last1=Huang|first1=Chaolin|last2=Wang|first2=Yeming|last3=Li|first3=Xingwang|last4=Ren|first4=Lili|last5=Zhao|first5=Jianping|last6=Hu|first6=Yi|last7=Zhang|first7=Li|last8=Fan|first8=Guohui|last9=Xu|first9=Jiuyang|last10=Gu|first10=Xiaoying|last11=Cheng|first11=Zhenshun|last12=Yu|first12=Ting|last13=Xia|first13=Jiaan|last14=Wei|first14=Yuan|last15=Wu|first15=Wenjuan|last16=Xie|first16=Xuelei|last17=Yin|first17=Wen|last18=Li|first18=Hui|last19=Liu|first19=Min|last20=Xiao|first20=Yan|last21=Gao|first21=Hong|last22=Guo|first22=Li|last23=Xie|first23=Jungang|last24=Wang|first24=Guangfa|last25=Jiang|first25=Rongmeng|last26=Gao|first26=Zhancheng|last27=Jin|first27=Qi|last28=Wang|first28=Jianwei|last29=Cao|first29=Bin|title=Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China|journal=The Lancet|volume=395|issue=10223|year=2020|pages=497–506|issn=01406736|doi=10.1016/S0140-6736(20)30183-5}}</ref> | ||
*The extensive lung damage is caused by multiple factors, such as: | |||
**High initial virus titers | |||
*Initial reports identified two species of snakes that could be the culprit reservoir of COVID-19. However, there is no consistent evidence of coronavirus reservoirs except mammals and birds.<ref name="BassettiVena2020">{{cite journal|last1=Bassetti|first1=Matteo|last2=Vena|first2=Antonio|last3=Giacobbe|first3=Daniele Roberto|title=The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm|journal=European Journal of Clinical Investigation|volume=50|issue=3|year=2020|issn=0014-2972|doi=10.1111/eci.13209}}</ref><br /> | *Initial reports identified two species of snakes that could be the culprit reservoir of COVID-19. However, there is no consistent evidence of coronavirus reservoirs except mammals and birds.<ref name="BassettiVena2020">{{cite journal|last1=Bassetti|first1=Matteo|last2=Vena|first2=Antonio|last3=Giacobbe|first3=Daniele Roberto|title=The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm|journal=European Journal of Clinical Investigation|volume=50|issue=3|year=2020|issn=0014-2972|doi=10.1111/eci.13209}}</ref><br /> | ||
==Reference== | ==Reference== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:00, 9 March 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Coronavirus disease 2019 (COVID-19) is caused by, SARS-CoV-2, a novel coronavirus named for the similarity of its symptoms to those caused by the severe acute respiratory syndrome.
Pathophysiology
Pathogenesis
- Coronavirus disease 2019 (COVID-19) is caused by, SARS-CoV-2, a novel coronavirus named for the similarity of its symptoms to those caused by the severe acute respiratory syndrome.[1][2]
- Unlike SARS-CoV, transmission of COVID-19 takes place during the prodromal period when those infected are mildly ill and are carrying on with their usual activities. This contributes to the spread of infection.[3]
- The main pathogenesis of COVID-19 is severe pneumonia, RNAemia, combined with the incidence of ground-glass opacities, and acute cardiac injury.[4]
- The extensive lung damage is caused by multiple factors, such as:
- High initial virus titers
- Initial reports identified two species of snakes that could be the culprit reservoir of COVID-19. However, there is no consistent evidence of coronavirus reservoirs except mammals and birds.[5]
Reference
- ↑ Lu, Jian; Cui, Jie; Qian, Zhaohui; Wang, Yirong; Zhang, Hong; Duan, Yuange; Wu, Xinkai; Yao, Xinmin; Song, Yuhe; Li, Xiang; Wu, Changcheng; Tang, Xiaolu (2020). "On the origin and continuing evolution of SARS-CoV-2". National Science Review. doi:10.1093/nsr/nwaa036. ISSN 2095-5138.
- ↑ Lu, Roujian; Zhao, Xiang; Li, Juan; Niu, Peihua; Yang, Bo; Wu, Honglong; Wang, Wenling; Song, Hao; Huang, Baoying; Zhu, Na; Bi, Yuhai; Ma, Xuejun; Zhan, Faxian; Wang, Liang; Hu, Tao; Zhou, Hong; Hu, Zhenhong; Zhou, Weimin; Zhao, Li; Chen, Jing; Meng, Yao; Wang, Ji; Lin, Yang; Yuan, Jianying; Xie, Zhihao; Ma, Jinmin; Liu, William J; Wang, Dayan; Xu, Wenbo; Holmes, Edward C; Gao, George F; Wu, Guizhen; Chen, Weijun; Shi, Weifeng; Tan, Wenjie (2020). "Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding". The Lancet. 395 (10224): 565–574. doi:10.1016/S0140-6736(20)30251-8. ISSN 0140-6736.
- ↑ Heymann, David L; Shindo, Nahoko (2020). "COVID-19: what is next for public health?". The Lancet. 395 (10224): 542–545. doi:10.1016/S0140-6736(20)30374-3. ISSN 0140-6736.
- ↑ Huang, Chaolin; Wang, Yeming; Li, Xingwang; Ren, Lili; Zhao, Jianping; Hu, Yi; Zhang, Li; Fan, Guohui; Xu, Jiuyang; Gu, Xiaoying; Cheng, Zhenshun; Yu, Ting; Xia, Jiaan; Wei, Yuan; Wu, Wenjuan; Xie, Xuelei; Yin, Wen; Li, Hui; Liu, Min; Xiao, Yan; Gao, Hong; Guo, Li; Xie, Jungang; Wang, Guangfa; Jiang, Rongmeng; Gao, Zhancheng; Jin, Qi; Wang, Jianwei; Cao, Bin (2020). "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China". The Lancet. 395 (10223): 497–506. doi:10.1016/S0140-6736(20)30183-5. ISSN 0140-6736.
- ↑ Bassetti, Matteo; Vena, Antonio; Giacobbe, Daniele Roberto (2020). "The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm". European Journal of Clinical Investigation. 50 (3). doi:10.1111/eci.13209. ISSN 0014-2972.