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* The B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins are currently under investigation as immune targets for development of vaccine.
* The B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins are currently under investigation as immune targets for development of vaccine.
* Phylogenetic similarity between SARS-CoV and COVID-19 at the level of structural proteins S, E, M, and N is providing guidance for development of a possible vaccine. <br />
* Phylogenetic similarity between SARS-CoV and COVID-19 at the level of structural proteins S, E, M, and N is providing guidance for development of a possible vaccine.  
 
=== Prior Work ===
The following table depicts major vaccine products that have been developed agains SARS-CoV and MERS-CoV:
<br />
{| class="wikitable"
|+
!Vaccine Base
!Antigen
!Clinical Testing
!Pros
!Cons
|-
|DNA
|
|
|
|
|-
|Viral Vector
|
|
|
|
|-
|Conjugated subunit
|
|
|
|
|-
|Virion
|
|
|
|
|-
|Inactivated
|
|
|
|
|-
|Live attenuated
|
|
|
|
|}
 
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 17:57, 16 March 2020

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Risk calculators and risk factors for COVID-19 future or investigational therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Future or Investigational Therapies

Immune Targets

  • The B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins are currently under investigation as immune targets for development of vaccine.
  • Phylogenetic similarity between SARS-CoV and COVID-19 at the level of structural proteins S, E, M, and N is providing guidance for development of a possible vaccine.

Prior Work

The following table depicts major vaccine products that have been developed agains SARS-CoV and MERS-CoV:

Vaccine Base Antigen Clinical Testing Pros Cons
DNA
Viral Vector
Conjugated subunit
Virion
Inactivated
Live attenuated

References

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