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==Overview== | ==Overview== | ||
'''Scurvy''' is a chronic [[deficiency disease]] of [[vitamin C]], which is necessary for normal [[collagen]] formation in humans. L-ascorbic acid, the scientific name for vitamin c, is derived from the Latin name, scorbutus. Early symptoms of this disease are fatigue, weakness, and sore arms and legs. Without treatment, changes in [[hair]], [[skin]], and [[gums]] occur. <ref name="pmid25983516">{{ | '''Scurvy''' is a chronic [[deficiency disease]] of [[vitamin C]], which is necessary for normal [[collagen]] formation in humans. L-ascorbic acid, the scientific name for vitamin c, is derived from the Latin name, scorbutus. Early symptoms of this disease are fatigue, weakness, and sore arms and legs. Without treatment, changes in [[hair]], [[skin]], and [[gums]] occur. <ref name="pmid25983516">{{cite journal| author=Agarwal A, Shaharyar A, Kumar A, Bhat MS, Mishra M| title=Scurvy in pediatric age group - A disease often forgotten? | journal=J Clin Orthop Trauma | year= 2015 | volume= 6 | issue= 2 | pages= 101-7 | pmid=25983516 | doi=10.1016/j.jcot.2014.12.003 | pmc=4411344 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25983516 }} </ref> As scurvy worsens there can be [[personality changes]], poor [[wound healing]] and ultimately leading to death due to [[bleeding]] or [[infection]]. <ref name="pmid"Vitamin C". Office of Dietary Supplements. 11 Fe">{{cite journal| author=Lefkowitz RJ| title=Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 18 | pages= 1651-8 | pmid="Vitamin C". Office of Dietary Supplements. 11 Fe | doi=10.1016/0006-2952(75)90001-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11 }} </ref> | ||
Previously, this disease was common among pirates, sailors, and all others who were separated from the resources of vitamin c e.g. [[fruits]] and [[vegetables]] for extended periods. It takes a month with low or no vitamin c to cause symptoms. <ref name=" | Previously, this disease was common among pirates, sailors, and all others who were separated from the resources of vitamin c e.g. [[fruits]] and [[vegetables]] for extended periods. It takes a month with low or no vitamin c to cause symptoms. <ref name="pmid"Scurvy". GARD. 1 September 2016. Archived from t">{{cite journal| author=Makar AB, McMartin KE, Palese M, Tephly TR| title=Formate assay in body fluids: application in methanol poisoning. | journal=Biochem Med | year= 1975 | volume= 13 | issue= 2 | pages= 117-26 | pmid="Scurvy". GARD. 1 September 2016. Archived from t | doi=10.1016/0006-2944(75)90147-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1 }} </ref> | ||
In infants, scurvy is sometimes referred to as '''Barlow's disease''', named after Sir [[Thomas Barlow]] (1845–1945), <ref name="pmid6423046">{{ | In infants, scurvy is sometimes referred to as '''Barlow's disease''', named after Sir [[Thomas Barlow]] (1845–1945), <ref name="pmid6423046">{{cite journal| author=Evans PR| title=Infantile scurvy: the centenary of Barlow's disease. | journal=Br Med J (Clin Res Ed) | year= 1983 | volume= 287 | issue= 6408 | pages= 1862-3 | pmid=6423046 | doi=10.1136/bmj.287.6408.1862 | pmc=1550031 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6423046 }} </ref> a British [[physician]] who described it. Other eponyms include '''Moeller's disease''' and '''Cheadle's disease'''. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 19:16, 3 June 2020
"sandbox:wd"
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Scurvy is a chronic deficiency disease of vitamin C, which is necessary for normal collagen formation in humans. L-ascorbic acid, the scientific name for vitamin c, is derived from the Latin name, scorbutus. Early symptoms of this disease are fatigue, weakness, and sore arms and legs. Without treatment, changes in hair, skin, and gums occur. [1] As scurvy worsens there can be personality changes, poor wound healing and ultimately leading to death due to bleeding or infection. Previously, this disease was common among pirates, sailors, and all others who were separated from the resources of vitamin c e.g. fruits and vegetables for extended periods. It takes a month with low or no vitamin c to cause symptoms. In infants, scurvy is sometimes referred to as Barlow's disease, named after Sir Thomas Barlow (1845–1945), [2] a British physician who described it. Other eponyms include Moeller's disease and Cheadle's disease.
Pathophysiology
Physiology
Pathogenesis
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
References
- ↑ Agarwal A, Shaharyar A, Kumar A, Bhat MS, Mishra M (2015). "Scurvy in pediatric age group - A disease often forgotten?". J Clin Orthop Trauma. 6 (2): 101–7. doi:10.1016/j.jcot.2014.12.003. PMC 4411344. PMID 25983516.
- ↑ Evans PR (1983). "Infantile scurvy: the centenary of Barlow's disease". Br Med J (Clin Res Ed). 287 (6408): 1862–3. doi:10.1136/bmj.287.6408.1862. PMC 1550031. PMID 6423046.