Sandbox: GDS: Difference between revisions
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| Line 7: | Line 7: | ||
*Precocious Puberty | *Precocious Puberty | ||
*Fibrous Dysplasia of Long Bones | *Fibrous Dysplasia of Long Bones | ||
*Cafe au lait spots | *Cafe au lait spots* | ||
**Irregular macules confined to one side of the body | |||
*So just writing in next line with * will continue the bullet points | |||
===Explanation=== | ===Explanation=== | ||
McCune Albright Syndrome occurs due to mutation in the GNAS gene which leads to constant G- protein activation which leads to overproduction of pituitary hormones.<br>Thus in addition to precocious puberty ( GnRH independent increase in LH and FSH), MAS can cause an increase in TSH and GH and ACTH leading to Cushing syndrome. | McCune Albright Syndrome occurs due to mutation in the GNAS gene which leads to constant G- protein activation which leads to overproduction of pituitary hormones.<br>Thus in addition to precocious puberty ( GnRH independent increase in LH and FSH), MAS can cause an increase in TSH and GH and ACTH leading to Cushing syndrome. | ||
Revision as of 17:09, 6 June 2020
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Mc Cune Albright syndrome
Clinical Features
- Precocious Puberty
- Fibrous Dysplasia of Long Bones
- Cafe au lait spots*
- Irregular macules confined to one side of the body
- So just writing in next line with * will continue the bullet points
Explanation
McCune Albright Syndrome occurs due to mutation in the GNAS gene which leads to constant G- protein activation which leads to overproduction of pituitary hormones.
Thus in addition to precocious puberty ( GnRH independent increase in LH and FSH), MAS can cause an increase in TSH and GH and ACTH leading to Cushing syndrome.
BVC
ABC
Insulinoma reference example[1]
Reference
- ↑ Metz DC, Jensen RT (November 2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.