Short QT syndrome classification: Difference between revisions
| Line 38: | Line 38: | ||
|KCNQ1, | |KCNQ1, | ||
KvLQT1 | KvLQT1<ref name="pmidhttps://doi.org/10.1161/CIRCEP.109.921056">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1161/CIRCEP.109.921056 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
|11p15.5-p15.4 | |11p15.5-p15.4 | ||
|Mutation in KCNQ1 causing gain of function of α-subunit Iks | |Mutation in KCNQ1 causing gain of function of α-subunit Iks | ||
| Line 48: | Line 48: | ||
|[https://www.omim.org/entry/609622?search=short%20QT%20syndrome-3&highlight=%28syndrome%7Csyndrome3%29%20qt%20short 609622] | |[https://www.omim.org/entry/609622?search=short%20QT%20syndrome-3&highlight=%28syndrome%7Csyndrome3%29%20qt%20short 609622] | ||
|KCNJ2, | |KCNJ2, | ||
Kir2.1 | Kir2.1<ref name="pmidhttps://doi.org/10.1161/CIRCEP.109.921056">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1161/CIRCEP.109.921056 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
|17q24.3 | |17q24.3 | ||
|Mutation in KCNJ2 gene causing gain of function of α-subunit IK1 | |Mutation in KCNJ2 gene causing gain of function of α-subunit IK1 | ||
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|CACNA1C, | |CACNA1C, | ||
Cav1.2 | Cav1.2<ref name="pmidhttps://doi.org/10.1161/CIRCEP.109.921056">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1161/CIRCEP.109.921056 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
|12p13.3 | |12p13.3 | ||
|Mutation in CACNB2b causing loss of function of α-subunit IL,Ca | |Mutation in CACNB2b causing loss of function of α-subunit IL,Ca | ||
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|CACNB2b, | |CACNB2b, | ||
Cavβ2b | Cavβ2b<ref name="pmidhttps://doi.org/10.1161/CIRCEP.109.921056">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.1161/CIRCEP.109.921056 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
|10p12 | |10p12 | ||
|Mutation in CACNA1c causing loss of function of β2-subunit IL,Ca | |Mutation in CACNA1c causing loss of function of β2-subunit IL,Ca | ||
Revision as of 16:53, 11 June 2020
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Short QT syndrome Microchapters |
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Short QT syndrome classification On the Web |
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Risk calculators and risk factors for Short QT syndrome classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Five variants of short QT syndrome have been characterized based upon the underlying genetic mutation, the electrocardiographic phenotype, and the clinical manifestations of the variant.
Classification
| Type | OMIM | Gene | Gene Location | Mutation | Protein | Notes | |
|---|---|---|---|---|---|---|---|
| 1 | SQTS 1[1][2] | 609620 | KCNH2
HERG |
7q 36.1 | Mutation in the KCNH2 gene causing gain of function of α-subunit Ikr | Kv11.1 | |
| 2 | SQTS 2[1][3] | 609621 | KCNQ1,
KvLQT1[4] |
11p15.5-p15.4 | Mutation in KCNQ1 causing gain of function of α-subunit Iks | Kv7.1 | |
| 3 | SQTS 3[1][5] | 609622 | KCNJ2,
Kir2.1[4] |
17q24.3 | Mutation in KCNJ2 gene causing gain of function of α-subunit IK1 | Kir2.1 | |
| 4 | SQTS 4[1][6] | CACNA1C,
Cav1.2[4] |
12p13.3 | Mutation in CACNB2b causing loss of function of α-subunit IL,Ca | Cav1.2 | ||
| 5 | SQTS 5[1][6] | CACNB2b,
Cavβ2b[4] |
10p12 | Mutation in CACNA1c causing loss of function of β2-subunit IL,Ca | Cavβ2 |
Short QT syndrome type 1 (SQT1)
The genetic studies reveal a mis-sense mutation in KCNH2 (HERG) causes SQTS type 1. It is the most common type of SQTS encountered till date. The KCNH2 gene is located on chromosome 7q 36.1. The KCNH2 gene is often referred as HERG gene. HERG stands for the human ether-a-go-go-related gene which expresses a protein Kv11.1. This protein forms the alpha subunit of potassium channel responsible for rapidly activating rectifier outwards current (Ikr) [7].The genetic analysis reveal mis-sense mutation with cytosine to guanine substitution at nucleotide 1764 resulting in change in the amino acid (N588K) in KCNH2 gene. The N588K mutation appears to be the main reason for occurrence of SQTS syndrome[1]. The Bio-physical analysis reveal a gain of function mutation in IKr currents causing shortening of action potential duration and refractoriness making patients prone to re-entrant type of arrythmias [8].
Short QT syndrome type 2 (SQT2)
Short QT syndrome type 3 (SQT3)
Short QT syndrome type 4 (SQT4)
Short QT syndrome type 5 (SQT5)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hedley PL, Jørgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA; et al. (2009). "The genetic basis of long QT and short QT syndromes: a mutation update". Hum Mutat. 30 (11): 1486–511. doi:10.1002/humu.21106. PMID 19862833.
- ↑ Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M; et al. (2004). "Sudden death associated with short-QT syndrome linked to mutations in HERG". Circulation. 109 (1): 30–5. doi:10.1161/01.CIR.0000109482.92774.3A. PMID 14676148.
- ↑ Bellocq C, van Ginneken AC, Bezzina CR, Alders M, Escande D, Mannens MM; et al. (2004). "Mutation in the KCNQ1 gene leading to the short QT-interval syndrome". Circulation. 109 (20): 2394–7. doi:10.1161/01.CIR.0000130409.72142.FE. PMID 15159330.
- ↑ 4.0 4.1 4.2 4.3 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.1161/CIRCEP.109.921056 Check
|pmid=value (help). - ↑ Priori SG, Pandit SV, Rivolta I, Berenfeld O, Ronchetti E, Dhamoon A; et al. (2005). "A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene". Circ Res. 96 (7): 800–7. doi:10.1161/01.RES.0000162101.76263.8c. PMID 15761194.
- ↑ 6.0 6.1 Antzelevitch C, Pollevick GD, Cordeiro JM, Casis O, Sanguinetti MC, Aizawa Y; et al. (2007). "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death". Circulation. 115 (4): 442–9. doi:10.1161/CIRCULATIONAHA.106.668392. PMC 1952683. PMID 17224476.
- ↑ Schimpf R, Borggrefe M, Wolpert C (2008). "Clinical and molecular genetics of the short QT syndrome". Curr Opin Cardiol. 23 (3): 192–8. doi:10.1097/HCO.0b013e3282fbf756. PMID 18382206.
- ↑ Hong K, Bjerregaard P, Gussak I, Brugada R (2005). "Short QT syndrome and atrial fibrillation caused by mutation in KCNH2". J Cardiovasc Electrophysiol. 16 (4): 394–6. doi:10.1046/j.1540-8167.2005.40621.x. PMID 15828882.