Asperger syndrome causes: Difference between revisions
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*There is a possible link to [[Autism (patient information)|autism]], and '''genetic factors''' may play a role. The disorder tends to run in families. A specific gene has not been identified. Although no specific gene has yet been identified, multiple factors are believed to play a role in the [[Expressivity|expression]] of autism, given the [[phenotype|phenotypic]] variability seen in this group of children. Evidence for a genetic link is the tendency for AS to run in families and an observed higher [[Incidence (epidemiology)|incidence]] of family members who have behavioral symptoms similar to AS but in a more limited form (for example, slight difficulties with social interaction, language, or reading). Most research suggests that all autism spectrum disorders have shared genetic mechanisms, but AS may have a stronger genetic component than autism. There is probably a common group of genes where particular [[allele]]s render an individual vulnerable to developing AS; if this is the case, the particular combination of alleles would determine the severity and symptoms for each individual with AS. | *There is a possible link to [[Autism (patient information)|autism]], and '''genetic factors''' may play a role. The disorder tends to run in families. A specific gene has not been identified. Although no specific gene has yet been identified, multiple factors are believed to play a role in the [[Expressivity|expression]] of autism, given the [[phenotype|phenotypic]] variability seen in this group of children. Evidence for a genetic link is the tendency for AS to run in families and an observed higher [[Incidence (epidemiology)|incidence]] of family members who have behavioral symptoms similar to AS but in a more limited form (for example, slight difficulties with social interaction, language, or reading). Most research suggests that all autism spectrum disorders have shared genetic mechanisms, but AS may have a stronger genetic component than autism. There is probably a common group of genes where particular [[allele]]s render an individual vulnerable to developing AS; if this is the case, the particular combination of alleles would determine the severity and symptoms for each individual with AS. | ||
* A few ASD cases have been linked to exposure to [[teratogen]]s (agents that cause [[birth defect]]s) during the first eight weeks from [[Human fertilization|conception]]. Although this does not exclude the possibility that ASD can be initiated or affected later, it is strong evidence that it arises very early in development.<ref name=Arndt>{{cite journal |journal= Int J Dev Neurosci |date=2005 |volume=23 |issue=2–3 |pages=189–99 |title= The teratology of autism |author= Arndt TL, Stodgell CJ, Rodier PM |doi=10.1016/j.ijdevneu.2004.11.001 |pmid=15749245}}</ref> Many environmental factors have been hypothesized to act after birth, but none has been confirmed by scientific investigation.<ref>{{cite journal |author= [[Michael Rutter|Rutter M]] |title= Incidence of autism spectrum disorders: changes over time and their meaning |journal= Acta Paediatr |volume=94 |issue=1 |date=2005 |pages=2–15 |pmid=15858952 |doi= 10.1080/08035250410023124}}</ref> | * A few ASD cases have been linked to exposure to [[teratogen]]s (agents that cause [[birth defect]]s) during the first eight weeks from [[Human fertilization|conception]]. Although this does not exclude the possibility that ASD can be initiated or affected later, it is strong evidence that it arises very early in development.<ref name="Arndt">{{cite journal |journal= Int J Dev Neurosci |date=2005 |volume=23 |issue=2–3 |pages=189–99 |title= The teratology of autism |author= Arndt TL, Stodgell CJ, Rodier PM |doi=10.1016/j.ijdevneu.2004.11.001 |pmid=15749245}}</ref> Many environmental factors have been hypothesized to act after birth, but none has been confirmed by scientific investigation.<ref>{{cite journal |author= [[Michael Rutter|Rutter M]] |title= Incidence of autism spectrum disorders: changes over time and their meaning |journal= Acta Paediatr |volume=94 |issue=1 |date=2005 |pages=2–15 |pmid=15858952 |doi= 10.1080/08035250410023124}}</ref> | ||
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== Overview == | |||
The exact cause of Asperger (AS) is unknown. Many factors including genetics, family history of autism spectrum disorders (ASD) and environmental factors such pre-/peri-/post-natal factors have been associated with autism ASD. | |||
== Causes == | |||
=== Genetic Causes === | |||
<br /> | |||
=== Family History of Autism Spectrum Disorder (ASD) === | |||
Several studies suggest that a familial history of autism spectrum disorder (ASD) is a risk factor for Asperger Syndrome (AS). (gillber2005) gazziudiin 2005 | |||
=== Prenatal Environment === | |||
=== Perinatal Environment === | |||
=== Postnatal Environment === | |||
==References== | ==References== | ||
Revision as of 10:58, 15 June 2020
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Causes
- The exact cause is unknown. More than likely, an abnormality in the brain is the cause of Asperger syndrome.
- There is a possible link to autism, and genetic factors may play a role. The disorder tends to run in families. A specific gene has not been identified. Although no specific gene has yet been identified, multiple factors are believed to play a role in the expression of autism, given the phenotypic variability seen in this group of children. Evidence for a genetic link is the tendency for AS to run in families and an observed higher incidence of family members who have behavioral symptoms similar to AS but in a more limited form (for example, slight difficulties with social interaction, language, or reading). Most research suggests that all autism spectrum disorders have shared genetic mechanisms, but AS may have a stronger genetic component than autism. There is probably a common group of genes where particular alleles render an individual vulnerable to developing AS; if this is the case, the particular combination of alleles would determine the severity and symptoms for each individual with AS.
- A few ASD cases have been linked to exposure to teratogens (agents that cause birth defects) during the first eight weeks from conception. Although this does not exclude the possibility that ASD can be initiated or affected later, it is strong evidence that it arises very early in development.[1] Many environmental factors have been hypothesized to act after birth, but none has been confirmed by scientific investigation.[2]
Overview
The exact cause of Asperger (AS) is unknown. Many factors including genetics, family history of autism spectrum disorders (ASD) and environmental factors such pre-/peri-/post-natal factors have been associated with autism ASD.
Causes
Genetic Causes
Family History of Autism Spectrum Disorder (ASD)
Several studies suggest that a familial history of autism spectrum disorder (ASD) is a risk factor for Asperger Syndrome (AS). (gillber2005) gazziudiin 2005
Prenatal Environment
Perinatal Environment
Postnatal Environment
References
- ↑ Arndt TL, Stodgell CJ, Rodier PM (2005). "The teratology of autism". Int J Dev Neurosci. 23 (2–3): 189–99. doi:10.1016/j.ijdevneu.2004.11.001. PMID 15749245.
- ↑ Rutter M (2005). "Incidence of autism spectrum disorders: changes over time and their meaning". Acta Paediatr. 94 (1): 2–15. doi:10.1080/08035250410023124. PMID 15858952.