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| ==History and Symptoms== | | ==History and Symptoms== |
| * Skin problems, such as light patches and thickened skin
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| * [[Seizures]]
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| * [[Behavior problems]]
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| * Learning disabilities - seen in 50% patients ranging from mild to profound,<ref name="memory-deficits">{{cite journal
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| | author = Ridler K, ''et al''
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| | title = Neuroanatomical Correlates of Memory Deficits in Tuberous Sclerosis Complex
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| | journal = Cerebral Cortex
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| | year = 2006
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| | id = PMID 16603714 }}</ref> and studies have reported that between 25% and 61% of affected individuals meet the diagnostic criteria for [[autism]], with an even higher proportion showing features of a broader [[pervasive developmental disorder]].<ref name="autism-prevalence">{{cite journal
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| | author = Harrison JE, Bolton, PF
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| | title = Annotation: Tuberous sclerosis
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| | journal = Journal of Child Psychology and Psychiatry
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| | year = 1997
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| | pages = 603-614
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| | volume = 38
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| | id = PMID 9315970}}</ref>
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| * [[Mental retardation]]
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| * Kidney problems
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| Most of the neurologic manifestations of tuberous sclerosis are due to the effects of hamartia (malformed tissue such as the cortical tubers),[[hamartoma]]s (benign growths such as facial [[angiofibroma]] and subependymal nodules) and, very rarely, cancerous hamartoblastomas on the brain tissue.
| | ==References== |
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| In infants, the first clue is often the presence of [[seizures]], [[delayed development]] or white patches on the skin. A full clinical diagnostic workup should be undertaken in such situations.<ref name="TSFactSheet">{{cite web
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| | url = http://www.ninds.nih.gov/disorders/tuberous_sclerosis/detail_tuberous_sclerosis.htm
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| | title = Tuberous Sclerosis Fact Sheet
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| | accessdate = 2006-10-03
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| | date = [[2006-04-11]]
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| | publisher = National Institute of Neurological Disorders and Stroke
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| }}</ref><ref name="TSAclinicalGuidelines">{{cite web
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| | url = http://www.tuberous-sclerosis.org/publications/clinicalguidelinessummary.pdf
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| | title = Summary of Clinical guidelines for the care of patients with Tuberous Sclerosis Complex
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| | accessdate = 2006-10-03
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| | year = 2002
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| | month = April
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| | publisher = Tuberous Sclerosis Association
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| }}</ref>
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| ==References== | | ==References== |