Intracranial hemorrhage medical therapy: Difference between revisions

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Pharmacologic therapy in patients with intracranial hemorrhage include:<ref name="CaceresGoldstein2012">{{cite journal|last1=Caceres|first1=J. Alfredo|last2=Goldstein|first2=Joshua N.|title=Intracranial Hemorrhage|journal=Emergency Medicine Clinics of North America|volume=30|issue=3|year=2012|pages=771–794|issn=07338627|doi=10.1016/j.emc.2012.06.003}}</ref>
Pharmacologic therapy in patients with intracranial hemorrhage include:<ref name="CaceresGoldstein2012">{{cite journal|last1=Caceres|first1=J. Alfredo|last2=Goldstein|first2=Joshua N.|title=Intracranial Hemorrhage|journal=Emergency Medicine Clinics of North America|volume=30|issue=3|year=2012|pages=771–794|issn=07338627|doi=10.1016/j.emc.2012.06.003}}</ref>
* Hemostatic therapy to correct the underlying coagulopathies. Agents that can be used to achieve this goal may differ based on the oral anticoagulant agent which resulted in the bleeding complications.  
* Hemostatic therapy to correct the underlying coagulopathies. Agents that can be used to achieve this goal may differ based on the oral anticoagulant agent which resulted in the bleeding complications.  
* The following agents can be used for warfarin reversal:
* The following agents can be used for warfarin reversal:<ref name="SteinerRosand2006">{{cite journal|last1=Steiner|first1=Thorsten|last2=Rosand|first2=Jonathan|last3=Diringer|first3=Michael|title=Intracerebral Hemorrhage Associated With Oral Anticoagulant Therapy|journal=Stroke|volume=37|issue=1|year=2006|pages=256–262|issn=0039-2499|doi=10.1161/01.STR.0000196989.09900.f8}}</ref><ref name="GoldsteinThomas2006">{{cite journal|last1=Goldstein|first1=Joshua N.|last2=Thomas|first2=Stephen H.|last3=Frontiero|first3=Virginia|last4=Joseph|first4=Annelise|last5=Engel|first5=Chana|last6=Snider|first6=Ryan|last7=Smith|first7=Eric E.|last8=Greenberg|first8=Stephen M.|last9=Rosand|first9=Jonathan|title=Timing of Fresh Frozen Plasma Administration and Rapid Correction of Coagulopathy in Warfarin-Related Intracerebral Hemorrhage|journal=Stroke|volume=37|issue=1|year=2006|pages=151–155|issn=0039-2499|doi=10.1161/01.STR.0000195047.21562.23}}</ref><ref name="HollandWarkentin2009">{{cite journal|last1=Holland|first1=Lorne|last2=Warkentin|first2=Theodore E.|last3=Refaai|first3=Majed|last4=Crowther|first4=Mark A.|last5=Johnston|first5=Marilyn A.|last6=Sarode|first6=Ravindra|title=Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose|journal=Transfusion|volume=49|issue=6|year=2009|pages=1171–1177|issn=00411132|doi=10.1111/j.1537-2995.2008.02080.x}}</ref>
**Fresh Frozen Plasma (FFP)  
**Fresh Frozen Plasma (FFP)  
**Prothrombin Complex Concentrates (PCCs)
**Prothrombin Complex Concentrates (PCCs)

Revision as of 17:02, 18 June 2020

Intracranial hemorrhage Microchapters

Patient Information

Overview

Classification

Subdural hematoma
Epidural hematoma
Subarachnoid hemorrhage
Intraventricular hemorrhage
Intraparenchymal hemorrhage

Causes

Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Medical Therapy

Pharmacologic therapy in patients with intracranial hemorrhage include:[1]

  • Hemostatic therapy to correct the underlying coagulopathies. Agents that can be used to achieve this goal may differ based on the oral anticoagulant agent which resulted in the bleeding complications.
  • The following agents can be used for warfarin reversal:[2][3][4]
    • Fresh Frozen Plasma (FFP)
    • Prothrombin Complex Concentrates (PCCs)
Contraindicated medications

Intracranial hemmorhage is considered an absolute contraindication to the use of the following medications:


References

  1. ↑ Caceres, J. Alfredo; Goldstein, Joshua N. (2012). "Intracranial Hemorrhage". Emergency Medicine Clinics of North America. 30 (3): 771–794. doi:10.1016/j.emc.2012.06.003. ISSN 0733-8627.
  2. ↑ Steiner, Thorsten; Rosand, Jonathan; Diringer, Michael (2006). "Intracerebral Hemorrhage Associated With Oral Anticoagulant Therapy". Stroke. 37 (1): 256–262. doi:10.1161/01.STR.0000196989.09900.f8. ISSN 0039-2499.
  3. ↑ Goldstein, Joshua N.; Thomas, Stephen H.; Frontiero, Virginia; Joseph, Annelise; Engel, Chana; Snider, Ryan; Smith, Eric E.; Greenberg, Stephen M.; Rosand, Jonathan (2006). "Timing of Fresh Frozen Plasma Administration and Rapid Correction of Coagulopathy in Warfarin-Related Intracerebral Hemorrhage". Stroke. 37 (1): 151–155. doi:10.1161/01.STR.0000195047.21562.23. ISSN 0039-2499.
  4. ↑ Holland, Lorne; Warkentin, Theodore E.; Refaai, Majed; Crowther, Mark A.; Johnston, Marilyn A.; Sarode, Ravindra (2009). "Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose". Transfusion. 49 (6): 1171–1177. doi:10.1111/j.1537-2995.2008.02080.x. ISSN 0041-1132.

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