Adrenoleukodystrophy MRI: Difference between revisions
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==MRI== | ==MRI== | ||
===Brain MRI=== | |||
*Abnormal bright signal intensities on the T2-weighted MRI images indicating demyelination of the white matter fibers and tracts.<ref name="pmid3659373">{{cite journal| author=Kumar AJ, Rosenbaum AE, Naidu S, Wener L, Citrin CM, Lindenberg R | display-authors=etal| title=Adrenoleukodystrophy: correlating MR imaging with CT. | journal=Radiology | year= 1987 | volume= 165 | issue= 2 | pages= 497-504 | pmid=3659373 | doi=10.1148/radiology.165.2.3659373 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3659373 }} </ref> | |||
*Involvement of Corticospinal tracts is the most common finding in male patients whereas in females there is mild diffuse increase of signal intensity in the parieto occipital or frontal lobe white matter.<ref name="pmid7677014">{{cite journal| author=Kumar AJ, Köhler W, Kruse B, Naidu S, Bergin A, Edwin D | display-authors=etal| title=MR findings in adult-onset adrenoleukodystrophy. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 6 | pages= 1227-37 | pmid=7677014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7677014 }} </ref> | |||
===Spinal Cord MRI=== | |||
*Magnetization transfer-weighted (MTw) images shows signal hyperintensities in the lateral and dorsal columns.<ref name="pmid15911801">{{cite journal| author=Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, van Zijl PC | display-authors=etal| title=Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. | journal=Neurology | year= 2005 | volume= 64 | issue= 10 | pages= 1739-45 | pmid=15911801 | doi=10.1212/01.WNL.0000164458.02141.06 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15911801 }} </ref> | |||
*Diffuse spinal cord atrophy, mainly in the thoracic and cervical regions. <ref name="pmid7677014">{{cite journal| author=Kumar AJ, Köhler W, Kruse B, Naidu S, Bergin A, Edwin D | display-authors=etal| title=MR findings in adult-onset adrenoleukodystrophy. | journal=AJNR Am J Neuroradiol | year= 1995 | volume= 16 | issue= 6 | pages= 1227-37 | pmid=7677014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7677014 }} </ref> | |||
==References== | ==References== |
Revision as of 13:26, 23 June 2020
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Overview
MRI
Brain MRI
- Abnormal bright signal intensities on the T2-weighted MRI images indicating demyelination of the white matter fibers and tracts.[1]
- Involvement of Corticospinal tracts is the most common finding in male patients whereas in females there is mild diffuse increase of signal intensity in the parieto occipital or frontal lobe white matter.[2]
Spinal Cord MRI
- Magnetization transfer-weighted (MTw) images shows signal hyperintensities in the lateral and dorsal columns.[3]
- Diffuse spinal cord atrophy, mainly in the thoracic and cervical regions. [2]
References
- ↑ Kumar AJ, Rosenbaum AE, Naidu S, Wener L, Citrin CM, Lindenberg R; et al. (1987). "Adrenoleukodystrophy: correlating MR imaging with CT". Radiology. 165 (2): 497–504. doi:10.1148/radiology.165.2.3659373. PMID 3659373.
- ↑ 2.0 2.1 Kumar AJ, Köhler W, Kruse B, Naidu S, Bergin A, Edwin D; et al. (1995). "MR findings in adult-onset adrenoleukodystrophy". AJNR Am J Neuroradiol. 16 (6): 1227–37. PMID 7677014.
- ↑ Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, van Zijl PC; et al. (2005). "Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy". Neurology. 64 (10): 1739–45. doi:10.1212/01.WNL.0000164458.02141.06. PMID 15911801.