Adrenoleukodystrophy other imaging findings: Difference between revisions
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==Overview== | ==Overview== | ||
'''Proton Magnetic Resonance Spectroscopic (MRS)''' imaging and '''Diffusion Tensor Imaging (DTI)''' may be helpful in the diagnosis of adrenoleukodystrophy | |||
==Other Imaging Findings== | ==Other Imaging Findings== | ||
'''Proton Magnetic Resonance Spectroscopic (MRS)''' imaging and '''Diffusion Tensor Imaging (DTI)''' may be helpful in the diagnosis of adrenoleukodystrophy. | |||
*These imaging techniques show changes in metabolic rates and water diffusion parameters. MRS imaging was able to demonstrate low NAA and high choline levels in white matter as a first indicator of metabolic dysfunction, prior to MRI changes in ALD. <ref name="pmid13679292">{{cite journal| author=Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW | display-authors=etal| title=Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. | journal=AJNR Am J Neuroradiol | year= 2003 | volume= 24 | issue= 8 | pages= 1683-9 | pmid=13679292 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679292 }} </ref> | *These imaging techniques show changes in metabolic rates and water diffusion parameters. MRS imaging was able to demonstrate low NAA and high choline levels in white matter as a first indicator of metabolic dysfunction, prior to MRI changes in ALD. <ref name="pmid13679292">{{cite journal| author=Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW | display-authors=etal| title=Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. | journal=AJNR Am J Neuroradiol | year= 2003 | volume= 24 | issue= 8 | pages= 1683-9 | pmid=13679292 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679292 }} </ref> | ||
*High directionality and structure of white matter, resulting from the directional morphology of myelinated axons, is quantified by a higher relative Fractional anisotropic (FA) with DTI.<ref name="TurkMoser2017">{{cite journal|last1=Turk|first1=Bela R.|last2=Moser|first2=Ann B.|last3=Fatemi|first3=Ali|title=Therapeutic strategies in adrenoleukodystrophy|journal=Wiener Medizinische Wochenschrift|volume=167|issue=9-10|year=2017|pages=219–226|issn=0043-5341|doi=10.1007/s10354-016-0534-2}}</ref> A decreased FA can be seen in central cALD lesion areas.<ref name="pmid13679292">{{cite journal| author=Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW | display-authors=etal| title=Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. | journal=AJNR Am J Neuroradiol | year= 2003 | volume= 24 | issue= 8 | pages= 1683-9 | pmid=13679292 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679292 }} </ref> | *High directionality and structure of white matter, resulting from the directional morphology of myelinated axons, is quantified by a higher relative Fractional anisotropic (FA) with DTI.<ref name="TurkMoser2017">{{cite journal|last1=Turk|first1=Bela R.|last2=Moser|first2=Ann B.|last3=Fatemi|first3=Ali|title=Therapeutic strategies in adrenoleukodystrophy|journal=Wiener Medizinische Wochenschrift|volume=167|issue=9-10|year=2017|pages=219–226|issn=0043-5341|doi=10.1007/s10354-016-0534-2}}</ref> A decreased FA can be seen in central cALD lesion areas.<ref name="pmid13679292">{{cite journal| author=Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW | display-authors=etal| title=Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. | journal=AJNR Am J Neuroradiol | year= 2003 | volume= 24 | issue= 8 | pages= 1683-9 | pmid=13679292 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679292 }} </ref> | ||
Latest revision as of 19:22, 28 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Proton Magnetic Resonance Spectroscopic (MRS) imaging and Diffusion Tensor Imaging (DTI) may be helpful in the diagnosis of adrenoleukodystrophy
Other Imaging Findings
Proton Magnetic Resonance Spectroscopic (MRS) imaging and Diffusion Tensor Imaging (DTI) may be helpful in the diagnosis of adrenoleukodystrophy.
- These imaging techniques show changes in metabolic rates and water diffusion parameters. MRS imaging was able to demonstrate low NAA and high choline levels in white matter as a first indicator of metabolic dysfunction, prior to MRI changes in ALD. [1]
- High directionality and structure of white matter, resulting from the directional morphology of myelinated axons, is quantified by a higher relative Fractional anisotropic (FA) with DTI.[2] A decreased FA can be seen in central cALD lesion areas.[1]
References
- ↑ 1.0 1.1 Pizzini F, Fatemi AS, Barker PB, Nagae-Poetscher LM, Horská A, Zimmerman AW; et al. (2003). "Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease". AJNR Am J Neuroradiol. 24 (8): 1683–9. PMID 13679292.
- ↑ Turk, Bela R.; Moser, Ann B.; Fatemi, Ali (2017). "Therapeutic strategies in adrenoleukodystrophy". Wiener Medizinische Wochenschrift. 167 (9–10): 219–226. doi:10.1007/s10354-016-0534-2. ISSN 0043-5341.