Paroxysmal supraventricular tachycardia pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
'''PSVTs are belived to be caused by abnormalities in impulse formation and conduction pathways.''' | |||
* | * '''Impulse Abnormalities:''' | ||
The impulse is affected by the previous action potential. In PSVT the abnormal impulse is due to: | |||
* | |||
· Early after-depolarization, which is promoted by: | |||
· Slow heart rate | |||
· Decreased or increased outward current | |||
· Delayed after-depolarization | |||
· Intracellular Ca++ overload | |||
* '''Conduction pathways:''' | |||
Different reentry circuits in the heart. | |||
==Genetics== | ==Genetics== |
Revision as of 06:14, 11 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Noha Elzeiny, M.B.B.Ch, M.Sc.[2]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
PSVTs are belived to be caused by abnormalities in impulse formation and conduction pathways.
- Impulse Abnormalities:
The impulse is affected by the previous action potential. In PSVT the abnormal impulse is due to:
· Early after-depolarization, which is promoted by:
· Slow heart rate
· Decreased or increased outward current
· Delayed after-depolarization
· Intracellular Ca++ overload
- Conduction pathways:
Different reentry circuits in the heart.
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].