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!Neurological symptoms | !Neurological symptoms | ||
!Acute Cerebrovascular disease | !Acute Cerebrovascular disease | ||
!Ischemic/Hemorrhagic Stroke | |||
|- | |- | ||
|April | |April 10, 2020 | ||
|Wuhan, China | |Wuhan, China | ||
|Mao et al.<ref name="MaoJin2020">{{cite journal|last1=Mao|first1=Ling|last2=Jin|first2=Huijuan|last3=Wang|first3=Mengdie|last4=Hu|first4=Yu|last5=Chen|first5=Shengcai|last6=He|first6=Quanwei|last7=Chang|first7=Jiang|last8=Hong|first8=Candong|last9=Zhou|first9=Yifan|last10=Wang|first10=David|last11=Miao|first11=Xiaoping|last12=Li|first12=Yanan|last13=Hu|first13=Bo|title=Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China|journal=JAMA Neurology|volume=77|issue=6|year=2020|pages=683|issn=2168-6149|doi=10.1001/jamaneurol.2020.1127}}</ref> | |Mao et al.<ref name="MaoJin2020">{{cite journal|last1=Mao|first1=Ling|last2=Jin|first2=Huijuan|last3=Wang|first3=Mengdie|last4=Hu|first4=Yu|last5=Chen|first5=Shengcai|last6=He|first6=Quanwei|last7=Chang|first7=Jiang|last8=Hong|first8=Candong|last9=Zhou|first9=Yifan|last10=Wang|first10=David|last11=Miao|first11=Xiaoping|last12=Li|first12=Yanan|last13=Hu|first13=Bo|title=Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China|journal=JAMA Neurology|volume=77|issue=6|year=2020|pages=683|issn=2168-6149|doi=10.1001/jamaneurol.2020.1127}}</ref> | ||
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|88 patients (41.1%), Mean age-58.2 years | |88 patients (41.1%), Mean age-58.2 years | ||
|78 patients (36.4%) | |78 patients (36.4%) | ||
|5 among severe [5.7%] infection group vs 1 [0.8%]) in non-severe | |5 among severe [5.7%] infection group vs 1 [0.8%]) in non-severe group | ||
|Ischemic-4, Hemorrhagic-1 | |||
|- | |- | ||
| | |May 29, 2020 | ||
| | |Wuhan, China | ||
| | |Qin et al.<ref name="QinZhou2020">{{cite journal|last1=Qin|first1=Chuan|last2=Zhou|first2=Luoqi|last3=Hu|first3=Ziwei|last4=Yang|first4=Sheng|last5=Zhang|first5=Shuoqi|last6=Chen|first6=Man|last7=Yu|first7=Haihan|last8=Tian|first8=Dai-Shi|last9=Wang|first9=Wei|title=Clinical Characteristics and Outcomes of COVID-19 Patients With a History of Stroke in Wuhan, China|journal=Stroke|volume=51|issue=7|year=2020|pages=2219–2223|issn=0039-2499|doi=10.1161/STROKEAHA.120.030365}}</ref> | ||
| | |1875 | ||
| | |461 severe on admission | ||
| | |||
|50 patients ie. 15 among severe and 35 among mild on admission (Median age-70 years), 30 males and 20 females | |||
| | | | ||
|- | |- | ||
| | |May 20, 2020 | ||
| | |New York | ||
| | |Yaghi et al.<ref name="YaghiIshida2020">{{cite journal|last1=Yaghi|first1=Shadi|last2=Ishida|first2=Koto|last3=Torres|first3=Jose|last4=Mac Grory|first4=Brian|last5=Raz|first5=Eytan|last6=Humbert|first6=Kelley|last7=Henninger|first7=Nils|last8=Trivedi|first8=Tushar|last9=Lillemoe|first9=Kaitlyn|last10=Alam|first10=Shazia|last11=Sanger|first11=Matthew|last12=Kim|first12=Sun|last13=Scher|first13=Erica|last14=Dehkharghani|first14=Seena|last15=Wachs|first15=Michael|last16=Tanweer|first16=Omar|last17=Volpicelli|first17=Frank|last18=Bosworth|first18=Brian|last19=Lord|first19=Aaron|last20=Frontera|first20=Jennifer|title=SARS-CoV-2 and Stroke in a New York Healthcare System|journal=Stroke|volume=51|issue=7|year=2020|pages=2002–2011|issn=0039-2499|doi=10.1161/STROKEAHA.120.030335}}</ref> | ||
| | |3556 | ||
| | |||
| | | | ||
| | | | ||
|Ischemic stroke- 32 patients (0.9%) | |||
|- | |- | ||
|April 6, 2020 | |April 6, 2020 | ||
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|85.6% | |85.6% | ||
| | |||
| | | | ||
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|59.41% | |59.41% | ||
| | |||
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|68% | |68% | ||
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|- | |- | ||
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|47% | |47% | ||
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|- | |- | ||
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|98.33% | |98.33% | ||
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|- | |- | ||
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|64.4% | |64.4% | ||
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|- | |- | ||
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|69.57% | |69.57% | ||
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|- | |- | ||
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|31.65% | |31.65% | ||
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|- | |- | ||
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|75.7% | |75.7% | ||
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|74% | |74% | ||
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|75.8% | |75.8% | ||
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|}<br /> | |}<br /> | ||
Revision as of 11:21, 12 July 2020
This page is for your practice!
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University Education
- The prevalence of COVID-19-associated stroke vary depending on study population (country, race, gender)
| Date of publication | Country | Author | Number of patients | Severe infection | Neurological symptoms | Acute Cerebrovascular disease | Ischemic/Hemorrhagic Stroke |
|---|---|---|---|---|---|---|---|
| April 10, 2020 | Wuhan, China | Mao et al.[1] | 214 | 88 patients (41.1%), Mean age-58.2 years | 78 patients (36.4%) | 5 among severe [5.7%] infection group vs 1 [0.8%]) in non-severe group | Ischemic-4, Hemorrhagic-1 |
| May 29, 2020 | Wuhan, China | Qin et al.[2] | 1875 | 461 severe on admission | 50 patients ie. 15 among severe and 35 among mild on admission (Median age-70 years), 30 males and 20 females | ||
| May 20, 2020 | New York | Yaghi et al.[3] | 3556 | Ischemic stroke- 32 patients (0.9%) | |||
| April 6, 2020 | European countries | Lechien et al.[4] | 417 | 85.6% | |||
| April 7, 2020 | United Kingdom | Menni et al.[5] | 579 | 59.41% | |||
| April 12, 2020 | United States | Yan et al.[6] | 59 | 68% | |||
| April 16, 2020 | France | Klopfenstein et al.[7] | 47 | 47% | |||
| April 17, 2020 | Iran | Moein et al.[8] | 60 | 98.33% | |||
| April 22, 2020 | United Kingdom | Spinato et al.[9] | 202 | 64.4% | |||
| April 22, 2020 | Iran | Heidari et al.[10] | 23 | 69.57% | |||
| April 22, 2020 | Spain | Beltran-Corbellini et al.[11] | 79 | 31.65% | |||
| April 24, 2020 | United States | Yan et al.[12] | 169 | 75.7% | |||
| May 1, 2020 | Germany | Luers et al.[13] | 72 | 74% | |||
| May 1, 2020 | Italy | Vaira et al.[14] | 33 | 75.8% |
University Education
Syncope is classified yo three categories:
- Vasovagal
- Neurogenic
- Cardiovascular.
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| DDx of syncope | ||||
|---|---|---|---|---|
- ↑ Mao, Ling; Jin, Huijuan; Wang, Mengdie; Hu, Yu; Chen, Shengcai; He, Quanwei; Chang, Jiang; Hong, Candong; Zhou, Yifan; Wang, David; Miao, Xiaoping; Li, Yanan; Hu, Bo (2020). "Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China". JAMA Neurology. 77 (6): 683. doi:10.1001/jamaneurol.2020.1127. ISSN 2168-6149.
- ↑ Qin, Chuan; Zhou, Luoqi; Hu, Ziwei; Yang, Sheng; Zhang, Shuoqi; Chen, Man; Yu, Haihan; Tian, Dai-Shi; Wang, Wei (2020). "Clinical Characteristics and Outcomes of COVID-19 Patients With a History of Stroke in Wuhan, China". Stroke. 51 (7): 2219–2223. doi:10.1161/STROKEAHA.120.030365. ISSN 0039-2499.
- ↑ Yaghi, Shadi; Ishida, Koto; Torres, Jose; Mac Grory, Brian; Raz, Eytan; Humbert, Kelley; Henninger, Nils; Trivedi, Tushar; Lillemoe, Kaitlyn; Alam, Shazia; Sanger, Matthew; Kim, Sun; Scher, Erica; Dehkharghani, Seena; Wachs, Michael; Tanweer, Omar; Volpicelli, Frank; Bosworth, Brian; Lord, Aaron; Frontera, Jennifer (2020). "SARS-CoV-2 and Stroke in a New York Healthcare System". Stroke. 51 (7): 2002–2011. doi:10.1161/STROKEAHA.120.030335. ISSN 0039-2499.
- ↑ Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S (April 2020). "Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study". Eur Arch Otorhinolaryngol. doi:10.1007/s00405-020-05965-1. PMC 7134551 Check
|pmc=value (help). PMID 32253535 Check|pmid=value (help). - ↑ Menni, Cristina; Valdes, Ana; Freydin, Maxim B; Ganesh, Sajaysurya; El-Sayed Moustafa, Julia; Visconti, Alessia; Hysi, Pirro; Bowyer, Ruth C E; Mangino, Massimo; Falchi, Mario; Wolf, Jonathan; Steves, Claire; Spector, Tim (2020). doi:10.1101/2020.04.05.20048421. Missing or empty
|title=(help) - ↑ Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS (April 2020). "Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms". Int Forum Allergy Rhinol. doi:10.1002/alr.22579. PMC 7262089 Check
|pmc=value (help). PMID 32279441 Check|pmid=value (help). - ↑ Klopfenstein, T.; Kadiane-Oussou, N.J.; Toko, L.; Royer, P.-Y.; Lepiller, Q.; Gendrin, V.; Zayet, S. (2020). "Features of anosmia in COVID-19". Médecine et Maladies Infectieuses. doi:10.1016/j.medmal.2020.04.006. ISSN 0399-077X.
- ↑
- ↑ Spinato, Giacomo; Fabbris, Cristoforo; Polesel, Jerry; Cazzador, Diego; Borsetto, Daniele; Hopkins, Claire; Boscolo-Rizzo, Paolo (2020). "Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection". JAMA. 323 (20): 2089. doi:10.1001/jama.2020.6771. ISSN 0098-7484.
- ↑ Heidari, F.; Karimi, E.; Firouzifar, M.; Khamushian, P.; Ansari, R.; Mohammadi Ardehali, M.; Heidari, F. (2020). "Anosmia as a Prominent Symptom of COVID-19 Infection". Rhinology journal. 58 (3): 302–303. doi:10.4193/Rhin20.140. ISSN 0300-0729.
- ↑ Beltrán‐Corbellini, Á.; Chico‐García, J. L.; Martínez‐Poles, J.; Rodríguez‐Jorge, F.; Natera‐Villalba, E.; Gómez‐Corral, J.; Gómez‐López, A.; Monreal, E.; Parra‐Díaz, P.; Cortés‐Cuevas, J. L.; Galán, J. C.; Fragola‐Arnau, C.; Porta‐Etessam, J.; Masjuan, J.; Alonso‐Cánovas, A. (2020). "Acute‐onset smell and taste disorders in the context of COVID‐19: a pilot multicentre polymerase chain reaction based case–control study". European Journal of Neurology. doi:10.1111/ene.14273. ISSN 1351-5101.
- ↑ Yan, Carol H.; Faraji, Farhoud; Prajapati, Divya P.; Ostrander, Benjamin T.; DeConde, Adam S. (2020). "Self‐reported olfactory loss associates with outpatient clinical course in COVID‐19". International Forum of Allergy & Rhinology. doi:10.1002/alr.22592. ISSN 2042-6976.
- ↑ Heindl, Ludwig M; Lehmann, Clara; Klein, Florian; Dewald, Felix; Augustin, Max; Wawer Matos, Philomena A; Loreck, Niklas; Rokohl, Alexander C; Luers, Jan C (2020). "Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19)". Clinical Infectious Diseases. doi:10.1093/cid/ciaa525. ISSN 1058-4838.
- ↑ Vaira, Luigi Angelo; Salzano, Giovanni; Petrocelli, Marzia; Deiana, Giovanna; Salzano, Francesco Antonio; De Riu, Giacomo (2020). "Validation of a self-administered olfactory and gustatory test for the remotely evaluation of COVID-19 patients in home quarantine". Head & Neck. doi:10.1002/hed.26228. ISSN 1043-3074.
| Patient | Past Medical History | Later presentation | GCS | Lab. Findings | Specific Tests | Imaging studies | ||
|---|---|---|---|---|---|---|---|---|
| CBC | CSF | MRI/CT scan | ||||||
| 1. 84-year old man in France presented with dyspnea and cough[1] | Diabetes Mellitus, | Worsening headache, Sore throat. (Day 5)
Impaired consciousness and transient generalized seizure, (Day 9) |
E4V1M1 | ↑WBCs and neutrophils ↓lymphocytes ↑ CRP |
Clear and colorless fluid,
Pressure=320 mmH2O, Cell count was 12/μL–10 |
RT-PCR for SARS-CoV-2 was positive in nasopharyngeal swab | Brain MRI:
Hyperintensity in the right lateral ventricle's inferior horn along the wall, | |
| 2. 74-year old man in France presented with confusion and influenza-like illness[1] | Flu like symptoms | Headache, nausea, dizziness, and
drug-refractory seizures. |
E4V5M6 | NA | NA | RT-PCR and antibody tests positive | Brain MRI: Hyperintensity in the left temporal lobe.
MR Spectroscopy: Decrease N-acetyl aspartate peak along with a marked elevated choline peak. | |
| 3. 31-year-old African American woman[2] | SCD patient with dyspnea | Paralysis and sedation (Day 13)
Comatose (Day 15) and death (Day 16) |
E0V0M0 | NA | Pressure=30cmH2O
115 nucleated cell /ml 7374 erythrocytes /ml Protein> 200mg/dl
|
RT=PCR for SARS-CoV-2 was positive in nasopharyngeal swab | Brain MRI: Nonenhancing cerebral edema and restricted diffusion in the right cerebral hemisphere with brain herniation. | |
- ↑ 1.0 1.1 Zayet, Souheil; Klopfenstein, Timothée; Kovẚcs, Róbert; Stancescu, Silviu; Hagenkötter, Beate (2020). "Acute Cerebral Stroke with Multiple Infarctions and COVID-19, France, 2020". Emerging Infectious Diseases. 26 (9). doi:10.3201/eid2609.201791. ISSN 1080-6040.
- ↑ Benameur K, Agarwal A, Auld SC, Butters MP, Webster AS, Ozturk T; et al. (2020). "Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020". Emerg Infect Dis. 26 (9). doi:10.3201/eid2609.202122. PMID 32487282 Check
|pmid=value (help).