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*The [[prevalence]] of [[COVID-19]]-associated [[stroke]] | *The [[prevalence]] of [[COVID-19]]-associated [[stroke]] varies in different studies | ||
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|Large vessel stroke | |Large vessel stroke-5, Mean age-<50 years | ||
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|July 12, 2020 | |July 12, 2020 | ||
Revision as of 11:31, 12 July 2020
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University Education
- The prevalence of COVID-19-associated stroke varies in different studies
| Date of publication | Country | Author | Number of patients | Severe infection | Neurological symptoms | Acute Cerebrovascular disease | Ischemic/Hemorrhagic Stroke |
|---|---|---|---|---|---|---|---|
| April 10, 2020 | Wuhan, China | Mao et al.[1] | 214 | 88 patients (41.1%), Mean age-58.2 years | 78 patients (36.4%) | 5 among severe [5.7%] infection group vs 1 [0.8%]) in non-severe group | Ischemic-4, Hemorrhagic-1 |
| May 29, 2020 | Wuhan, China | Qin et al.[2] | 1875 | 461 severe on admission | 50 patients ie. 15 among severe and 35 among mild on admission (Median age-70 years), 30 males and 20 females | ||
| May 20, 2020 | New York | Yaghi et al.[3] | 3556 | Ischemic stroke- 32 patients (0.9%) | |||
| April 28, 2020 | New York city | Oxley et al.[4] | 5 | Large vessel stroke-5, Mean age-<50 years | |||
| July 12, 2020 | United Kingdom | Menni et al.[5] | 579 | 59.41% |
|
University Education
Syncope is classified yo three categories:
- Vasovagal
- Neurogenic
- Cardiovascular.
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- ↑ Mao, Ling; Jin, Huijuan; Wang, Mengdie; Hu, Yu; Chen, Shengcai; He, Quanwei; Chang, Jiang; Hong, Candong; Zhou, Yifan; Wang, David; Miao, Xiaoping; Li, Yanan; Hu, Bo (2020). "Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China". JAMA Neurology. 77 (6): 683. doi:10.1001/jamaneurol.2020.1127. ISSN 2168-6149.
- ↑ Qin, Chuan; Zhou, Luoqi; Hu, Ziwei; Yang, Sheng; Zhang, Shuoqi; Chen, Man; Yu, Haihan; Tian, Dai-Shi; Wang, Wei (2020). "Clinical Characteristics and Outcomes of COVID-19 Patients With a History of Stroke in Wuhan, China". Stroke. 51 (7): 2219–2223. doi:10.1161/STROKEAHA.120.030365. ISSN 0039-2499.
- ↑ Yaghi, Shadi; Ishida, Koto; Torres, Jose; Mac Grory, Brian; Raz, Eytan; Humbert, Kelley; Henninger, Nils; Trivedi, Tushar; Lillemoe, Kaitlyn; Alam, Shazia; Sanger, Matthew; Kim, Sun; Scher, Erica; Dehkharghani, Seena; Wachs, Michael; Tanweer, Omar; Volpicelli, Frank; Bosworth, Brian; Lord, Aaron; Frontera, Jennifer (2020). "SARS-CoV-2 and Stroke in a New York Healthcare System". Stroke. 51 (7): 2002–2011. doi:10.1161/STROKEAHA.120.030335. ISSN 0039-2499.
- ↑ Oxley, Thomas J.; Mocco, J.; Majidi, Shahram; Kellner, Christopher P.; Shoirah, Hazem; Singh, I. Paul; De Leacy, Reade A.; Shigematsu, Tomoyoshi; Ladner, Travis R.; Yaeger, Kurt A.; Skliut, Maryna; Weinberger, Jesse; Dangayach, Neha S.; Bederson, Joshua B.; Tuhrim, Stanley; Fifi, Johanna T. (2020). "Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young". New England Journal of Medicine. 382 (20): e60. doi:10.1056/NEJMc2009787. ISSN 0028-4793.
- ↑ Menni, Cristina; Valdes, Ana; Freydin, Maxim B; Ganesh, Sajaysurya; El-Sayed Moustafa, Julia; Visconti, Alessia; Hysi, Pirro; Bowyer, Ruth C E; Mangino, Massimo; Falchi, Mario; Wolf, Jonathan; Steves, Claire; Spector, Tim (2020). doi:10.1101/2020.04.05.20048421. Missing or empty
|title=(help)
| Patient | Past Medical History | Later presentation | GCS | Lab. Findings | Specific Tests | Imaging studies | ||
|---|---|---|---|---|---|---|---|---|
| CBC | CSF | MRI/CT scan | ||||||
| 1. 84-year old man in France presented with dyspnea and cough[1] | Diabetes Mellitus, | Worsening headache, Sore throat. (Day 5)
Impaired consciousness and transient generalized seizure, (Day 9) |
E4V1M1 | ↑WBCs and neutrophils ↓lymphocytes ↑ CRP |
Clear and colorless fluid,
Pressure=320 mmH2O, Cell count was 12/μL–10 |
RT-PCR for SARS-CoV-2 was positive in nasopharyngeal swab | Brain MRI:
Hyperintensity in the right lateral ventricle's inferior horn along the wall, | |
| 2. 74-year old man in France presented with confusion and influenza-like illness[1] | Flu like symptoms | Headache, nausea, dizziness, and
drug-refractory seizures. |
E4V5M6 | NA | NA | RT-PCR and antibody tests positive | Brain MRI: Hyperintensity in the left temporal lobe.
MR Spectroscopy: Decrease N-acetyl aspartate peak along with a marked elevated choline peak. | |
| 3. 31-year-old African American woman[2] | SCD patient with dyspnea | Paralysis and sedation (Day 13)
Comatose (Day 15) and death (Day 16) |
E0V0M0 | NA | Pressure=30cmH2O
115 nucleated cell /ml 7374 erythrocytes /ml Protein> 200mg/dl
|
RT=PCR for SARS-CoV-2 was positive in nasopharyngeal swab | Brain MRI: Nonenhancing cerebral edema and restricted diffusion in the right cerebral hemisphere with brain herniation. | |
- ↑ 1.0 1.1 Zayet, Souheil; Klopfenstein, Timothée; Kovẚcs, Róbert; Stancescu, Silviu; Hagenkötter, Beate (2020). "Acute Cerebral Stroke with Multiple Infarctions and COVID-19, France, 2020". Emerging Infectious Diseases. 26 (9). doi:10.3201/eid2609.201791. ISSN 1080-6040.
- ↑ Benameur K, Agarwal A, Auld SC, Butters MP, Webster AS, Ozturk T; et al. (2020). "Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020". Emerg Infect Dis. 26 (9). doi:10.3201/eid2609.202122. PMID 32487282 Check
|pmid=value (help).