COVID-19-associated multisystem inflammatory syndrome differential diagnosis: Difference between revisions

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|7.38 (2.4-15.4)
|7.38 (2.4-15.4)
|-
|-
|'''Total white cell count (*10^9/L)'''
|'''Total [[white blood cell]] count (*10^9/L)'''
|17 (12-22)
|17 (12-22)
|13.4 (10.5-17.3)
|13.4 (10.5-17.3)
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|15.6 (7.5-20)
|15.6 (7.5-20)
|-
|-
|'''Neutrophil count (*10^9/L)'''
|'''[[Neutrophil]] count (*10^9/L)'''
|13 (10-19)  
|13 (10-19)  
|7.2 (5.1-9.9)
|7.2 (5.1-9.9)
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|16.4 (12-22)
|16.4 (12-22)
|-
|-
|'''Lymphocyte count (*10^9/L)'''
|'''[[Lymphocyte]] count (*10^9/L)'''
|0.8 (0.5-1.5)
|0.8 (0.5-1.5)
|2.8 (1.5-4.4)
|2.8 (1.5-4.4)
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|0.63 (0.41, 1.13)
|0.63 (0.41, 1.13)
|-
|-
|'''Hemoglobin (g/L)'''
|'''[[Hemoglobin]] (g/L)'''
|92 (83-103)
|92 (83-103)
|111.0 (105-119)
|111.0 (105-119)
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|114 (98-130)
|114 (98-130)
|-
|-
|'''Platelet number (10^9/L)'''
|'''[[Platelet]] number (10^9/L)'''
|151 (104-210)
|151 (104-210)
|365.0 (288-462)
|365.0 (288-462)
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|155 (92- 255)
|155 (92- 255)
|-
|-
|'''C-reactive protein (mg/L)'''
|'''[[C-reactive protein]] (mg/L)'''
|229 (156-338)
|229 (156-338)
|67.0(40-150)
|67.0(40-150)
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|201 (122, 317)
|201 (122, 317)
|-
|-
|'''ALT (IU/L)'''
|'''[[ALT]] (IU/L)'''
|42 (26-95)
|42 (26-95)
|42.0 (24-112)
|42.0 (24-112)
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|30.00 (22.10, 49.25)
|30.00 (22.10, 49.25)
|-
|-
|'''Albumin (g/L)'''
|'''[[Albumin]] (g/L)'''
|24 (21-27)
|24 (21-27)
|38.0 (35-41)
|38.0 (35-41)
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|27.00 (21.00, 31.00)
|27.00 (21.00, 31.00)
|-
|-
|'''Ferritin (ug/L)'''
|'''[[Ferritin]] (ug/L)'''
|610 (359-1280)
|610 (359-1280)
|200 (143-243)
|200 (143-243)
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| -
| -
|-
|-
|'''Troponin (ng/L)'''
|'''[[Troponin]] (ng/L)'''
|45 (8-294)
|45 (8-294)
|10.0 (10-20)
|10.0 (10-20)
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| -
| -
|-
|-
|'''D-dimer (ng/ml)'''
|'''[[D-dimer]] (ng/ml)'''
|3578 (2085- 8235)
|3578 (2085- 8235)
|1650 (970-2660)
|1650 (970-2660)
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*To view the differential diagnosis of COVID-19-associated multisystem inflammatory syndrome, [[Kawasaki disease differential diagnosis|click here]].<br />
*To view the differential diagnosis of COVID-19-associated multisystem inflammatory syndrome, [[Kawasaki disease differential diagnosis|click here]].<br />
*To view the differential diagnosis of COVID-19, [[COVID-19 differential diagnosis|click here]].<br />
*To view the differential diagnosis of COVID-19, [[COVID-19 differential diagnosis|click here]].<br />
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 20:26, 19 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: José Eduardo Riceto Loyola Junior, M.D.[2]

Overview

COVID-19-associated multisystem inflammatory syndrome must be differentiated from other diseases that cause conjunctival injection, cervical lymphadenopathy, and erythematous hands and feet, such as Kawasaki's disease and toxic shock syndrome.

Differentiating COVID-19-associated multisystem inflammatory syndrome Disease from other disease

Summary of laboratory parameters of a COVID-19-associated multisystem inflammatory syndrome cohort compared with the historic cohorts of Kawasaki Disease, Kawasaki Disease Shock Syndrome and Toxic Shock Syndrome[1]
Parameters COVID-19-associated multisystem inflammatory syndrome (PIMS-TS) Kawasaki Disease (KD) Kawasaki Disease Shock (KDS) Toxic Shock Syndrome (TSS)
Age (median, IQR) 9 (5.7-14) 2.7 (1.4-4.7) 3.8 (0.2-18) 7.38 (2.4-15.4)
Total white blood cell count (*10^9/L) 17 (12-22) 13.4 (10.5-17.3) 12.1 (7.9-15.5) 15.6 (7.5-20)
Neutrophil count (*10^9/L) 13 (10-19) 7.2 (5.1-9.9) 5.5 (3.2-10.3) 16.4 (12-22)
Lymphocyte count (*10^9/L) 0.8 (0.5-1.5) 2.8 (1.5-4.4) 1.6 (1-2.5) 0.63 (0.41, 1.13)
Hemoglobin (g/L) 92 (83-103) 111.0 (105-119) 107 (98-115) 114 (98-130)
Platelet number (10^9/L) 151 (104-210) 365.0 (288-462) 235 (138-352) 155 (92- 255)
C-reactive protein (mg/L) 229 (156-338) 67.0(40-150) 193 (83-237) 201 (122, 317)
ALT (IU/L) 42 (26-95) 42.0 (24-112) 73 (34-107) 30.00 (22.10, 49.25)
Albumin (g/L) 24 (21-27) 38.0 (35-41) 30 (27-35) 27.00 (21.00, 31.00)
Ferritin (ug/L) 610 (359-1280) 200 (143-243) 301 (228-337) -
NT-Pro-BNP (pg/ml) 788 (174-10548) 41 (12-102) 396 (57-1520) -
Troponin (ng/L) 45 (8-294) 10.0 (10-20) 10 (10-30) -
D-dimer (ng/ml) 3578 (2085- 8235) 1650 (970-2660) 2580 (1460- 2990) -
  • To view the differential diagnosis of COVID-19-associated multisystem inflammatory syndrome, click here.
  • To view the differential diagnosis of COVID-19, click here.

References

  1. ↑ 1.0 1.1 Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P; et al. (2020). "Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2". JAMA. doi:10.1001/jama.2020.10369. PMC 7281356 Check |pmc= value (help). PMID 32511692 Check |pmid= value (help).
  2. ↑ Cheung EW, Zachariah P, Gorelik M, Boneparth A, Kernie SG, Orange JS; et al. (2020). "Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City". JAMA. doi:10.1001/jama.2020.10374. PMC 7281352 Check |pmc= value (help). PMID 32511676 Check |pmid= value (help).
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