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{{Renal papillary necrosis}} | {{Renal papillary necrosis}} | ||
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{{CMG}}; {{AE}} {{NN}}<br> | |||
=== | ==Overview== | ||
[[ | * [[Renal papillary necrosis]] is associated with damaging the [[renal]] [[medullary]] and [[papillary]] cells due to many diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], [[pyelonephritis]], [[tuberculosis]], [[vasculitis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] abuse.<br> | ||
==Causes== | |||
[[Mefenamic acid]] | *Common causes of [[renal papillary necrosis]] include<ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414 }} </ref>: | ||
**[[Diabetes]] | |||
[[Meloxicam]] | **[[Sickle cell disease]]: most common cause in children | ||
**[[Urinary tract obstruction]] | |||
[[Piroxicam]] | **[[Renal vein thrombosis]] | ||
**upper [[urinary tract infection]] or [[pyelonephritis]] | |||
**[[Tuberculosis]] | |||
** systemic [[vasculitis]] | |||
**[[Renal]] [[transplant rejection]] | |||
**long term [[analgesics]] abuse such as [[acetaminophen]] and [[NSAIDS]] | |||
*** [[NSAIDS]] include: | |||
****[[Aspirin]] | |||
****[[Ibuprofen]] | |||
****[[Mefenamic acid]] | |||
****[[Indomethacin]] | |||
****[[Naproxen]] | |||
****[[Meloxicam]] | |||
****[[Diclofenac]] | |||
****[[Piroxicam]] | |||
****[[ketorolac]] | |||
==References== | ==References== | ||
Revision as of 14:14, 28 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]
Overview
- Renal papillary necrosis is associated with damaging the renal medullary and papillary cells due to many diseases such as diabetes, sickle cell disease, urinary tract obstruction, renal vein thrombosis, pyelonephritis, tuberculosis, vasculitis, renal transplant rejection and long term analgesics abuse.
Causes
- Common causes of renal papillary necrosis include[1][2]:
- Diabetes
- Sickle cell disease: most common cause in children
- Urinary tract obstruction
- Renal vein thrombosis
- upper urinary tract infection or pyelonephritis
- Tuberculosis
- systemic vasculitis
- Renal transplant rejection
- long term analgesics abuse such as acetaminophen and NSAIDS
References
- ↑ Brix AE (2002). "Renal papillary necrosis". Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
- ↑ Sabatini S (1984). "Pathophysiology of drug-induced papillary necrosis". Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.
[[Category:Disease]