Concussion natural history, complications and prognosis: Difference between revisions
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Latest revision as of 21:03, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Prognosis
MTBI has a mortality rate of almost zero. The symptoms of most concussions resolve within weeks, but problems may persist. It is not common for problems to be permanent, and outcome is usually excellent.[1] People over age 55 may take longer to heal from MTBI or may heal incompletely.[2] Similarly, factors such as a previous head injury or a coexisting medical condition have been found to predict longer-lasting post-concussion symptoms. Other factors that may lengthen recovery time after MTBI include psychological problems such as substance abuse or clinical depression, poor health before the injury or additional injuries sustained during it, and life stress.[1] Longer periods of amnesia or loss of consciousness immediately after the injury may indicate longer recovery times from residual symptoms. For unknown reasons, having had one concussion significantly increases a person's risk of having another. The prognosis may differ between concussed adults and children. Little research has been done on concussion in the pediatric population, but concern exists that severe concussions could interfere with brain development in children.
Complications
Post-concussion Syndrome
In post-concussion syndrome, symptoms do not resolve for weeks, months, or years after a concussion, and may occasionally be permanent.[3] Symptoms may include headaches, dizziness, fatigue, anxiety, memory and attention problems, sleep problems, and irritability.[4] There is no scientifically established treatment and rest, a recommended recovery technique, has limited effectiveness. Symptoms usually go away on their own within months. The question of whether the syndrome is the result of structural damage or other factors such as psychological ones, or a combination of these, has long been the subject of debate.[5]
Cumulative Effects
Cumulative effects of concussions are poorly understood. The severity of concussions and their symptoms may worsen with successive injuries, even if a subsequent injury occurs months or years after an initial one.[6] Symptoms may be more severe and changes in neurophysiology can occur with the third and subsequent concussions. Studies have had conflicting findings on whether athletes have longer recovery times after repeat concussions and whether cumulative effects such as impairment in cognition and memory occur.[7]
Cumulative effects may include psychiatric disorders and loss of long-term memory. For example, the risk of developing clinical depression has been found to be significantly greater for retired football players with a history of three or more concussions than for those with no concussion history.[8] Three or more concussions is also associated with a five-fold greater chance of developing Alzheimer's disease earlier and a three-fold greater chance of developing memory deficits.[8]
Second-impact Syndrome
Second-impact syndrome, in which the brain swells dangerously after a minor blow, may occur in very rare cases. The condition may develop in people who receive a second blow days or weeks after an initial concussion, before its symptoms have gone away. No one is certain of the cause of this often fatal complication, but it is commonly thought that the swelling occurs because the brain's arterioles lose the ability to regulate their diameter, causing a loss of control over cerebral blood flow. As the brain swells, intracranial pressure rapidly rises. The brain can herniate, and the brain stem can fail within five minutes. Except in boxing, all cases have occurred in athletes under age 20. Due to the very small number of documented cases, the diagnosis is controversial, and doubt exists about its validity.[9]
Dementia Pugilistica
Chronic encephalopathy is an example of the cumulative damage that can occur as the result of multiple concussions or less severe blows to the head. The condition called dementia pugilistica, or "punch drunk" syndrome, which is associated with boxers, can result in cognitive and physical deficits such as parkinsonism, speech and memory problems, slowed mental processing, tremor, and inappropriate behavior.[10] It shares features with Alzheimer's disease.[11]
References
- ↑ 1.0 1.1 Iverson GL (2005). "Outcome from mild traumatic brain injury". Current Opinion in Psychiatry. 18 (3): 301–317. doi:10.1097/01.yco.0000165601.29047.ae. PMID 16639155.
- ↑ Alexander MP (1995). "Mild traumatic brain injury: Pathophysiology, natural history, and clinical management". Neurology. 45 (7): 1253–1260. PMID 7617178.
- ↑ Ryan LM, Warden DL (2003). "Post concussion syndrome". International Review of Psychiatry. 15 (4): 310–316. doi:10.1080/09540260310001606692. PMID 15276952.
- ↑
Boake C, McCauley SR, Levin HS, Pedroza C, Contant CF, Song JX; et al. (2005). "Diagnostic criteria for postconcussional syndrome after mild to moderate traumatic brain injury". Journal of Neuropsychiatry and Clinical Neurosciences. 17 (3): 350–356. doi:doi: 10.1176/appi.neuropsych.17.3.350 Check
|doi=value (help). PMID 16179657. - ↑ Bryant RA (2008). "Disentangling mild traumatic brain injury and stress reactions". New England Journal of Medicine. 358 (5): 525–527. doi:10.1056/NEJMe078235. PMID 18234757.
- ↑ Harmon KG (1999). "Assessment and management of concussion in sports". American Family Physician. 60 (3): 887–892, 894. PMID 10498114.
- ↑ Pellman EJ, Viano DC (2006). "Concussion in professional football: Summary of the research conducted by the National Football League's Committee on Mild Traumatic Brain Injury" (PDF). Neurosurgical Focus. 21 (4): E12. PMID 17112190.
- ↑ 8.0 8.1 Cantu RC (2007). "Chronic traumatic encephalopathy in the National Football League". Neurosurgery. 61 (2): 223–225. doi:10.1227/01.NEU.0000255514.73967.90. PMID 17762733.
- ↑ McCrory P (2001). "Does second impact syndrome exist?". Clinical Journal of Sport Medicine. 11 (3): 144–149. PMID 11495318.
- ↑ Mendez MF (1995). "The neuropsychiatric aspects of boxing". International Journal of Psychiatry in Medicine. 25 (3): 249–262. PMID 8567192.
- ↑ Jordan BD (2000). "Chronic traumatic brain injury associated with boxing". Seminars in Neurology. 20 (2): 179–85. doi:10.1055/s-2000-9826. PMID 10946737.