Relapsing fever laboratory findings: Difference between revisions
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*With subsequent febrile episodes, the number of circulating spirochetes decreases, making it harder to detect spirochetes on a peripheral blood smear. Even during the initial episode spirochetes will only be seen 70% of the time. <ref name="pmid26618151">{{cite journal |vauthors=Fotso Fotso A, Drancourt M |title=Laboratory Diagnosis of Tick-Borne African Relapsing Fevers: Latest Developments |journal=Front Public Health |volume=3 |issue= |pages=254 |date=2015 |pmid=26618151 |pmc=4641162 |doi=10.3389/fpubh.2015.00254 |url=}}</ref> | *With subsequent febrile episodes, the number of circulating spirochetes decreases, making it harder to detect spirochetes on a peripheral blood smear. Even during the initial episode spirochetes will only be seen 70% of the time. <ref name="pmid26618151">{{cite journal |vauthors=Fotso Fotso A, Drancourt M |title=Laboratory Diagnosis of Tick-Borne African Relapsing Fevers: Latest Developments |journal=Front Public Health |volume=3 |issue= |pages=254 |date=2015 |pmid=26618151 |pmc=4641162 |doi=10.3389/fpubh.2015.00254 |url=}}</ref> | ||
'''Blood culture''' | '''Blood culture''' and '''Serologic tests''' such as antibody tests and [[PCR]] are available through public health laboratories and some private laboratories. Although there are false-positive and false-negative results. | ||
'''Other laboratory findings include: | '''Other laboratory findings include: | ||
More common: | More common: | ||
*Normal to increased white blood cell count with a left shift towards immature cells | *Normal to increased white blood cell count with a left shift towards immature cells | ||
Revision as of 20:35, 9 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Laboratory Findings
Blood smear:
- The presence of spirochetes in smears of peripheral blood, bone marrow, or cerebrospinal fluid in a symptomatic person is diagnostic of relapsing fever. Although best visualized by darkfield microscopy, the organisms can also be detected by Wright-Giemsa or acridine orange-stained preparations.
- With subsequent febrile episodes, the number of circulating spirochetes decreases, making it harder to detect spirochetes on a peripheral blood smear. Even during the initial episode spirochetes will only be seen 70% of the time. [1]
Blood culture and Serologic tests such as antibody tests and PCR are available through public health laboratories and some private laboratories. Although there are false-positive and false-negative results.
Other laboratory findings include:
More common:
- Normal to increased white blood cell count with a left shift towards immature cells
- Mild to moderate thrombocytopenia
- Mild anemia
- Elevated ESR
Less common:
- Mildly increased serum bilirubin and hepatic aminotransferase level
- increased urea nitrogen, creatinine
- Slightly prolonged coagulation tests, PT and APTT, as well as proteinuria or hematuria, are also common
References
- ↑ Fotso Fotso A, Drancourt M (2015). "Laboratory Diagnosis of Tick-Borne African Relapsing Fevers: Latest Developments". Front Public Health. 3: 254. doi:10.3389/fpubh.2015.00254. PMC 4641162. PMID 26618151.