Renal papillary necrosis causes: Difference between revisions
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{{CMG}}; {{AE}} {{NN}}<br> | {{CMG}}; {{AE}} {{NN}}<br> | ||
==Overview== | ==Overview== | ||
* [[Renal papillary necrosis]] is associated with damaging the [[renal]] [[medullary]] and [[papillary]] cells due to many diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], [[pyelonephritis]], [[tuberculosis]], [[vasculitis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] abuse.<br> | * [[Renal papillary necrosis]] is associated with damaging the [[renal]] [[medullary]] and [[papillary]] cells due to many diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], [[pyelonephritis]], [[tuberculosis]], [[vasculitis]], [[cirrhosis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] and [[alcohol]] abuse. In infants, it is associated with [[asphyxia]], [[dehydration]], and [[sepsis]]. | ||
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==Causes== | ==Causes== | ||
*Common causes of [[renal papillary necrosis]] include<ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414 }} </ref>: | *Common causes of [[renal papillary necrosis]] include<ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414 }} </ref><ref name="pmid28341428">{{cite journal| author=Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D | display-authors=etal| title=Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis. | journal=J Pediatr Urol | year= 2017 | volume= 13 | issue= 3 | pages= 250-256 | pmid=28341428 | doi=10.1016/j.jpurol.2017.01.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28341428 }} </ref>: | ||
**[[Diabetes]] | **[[Diabetes]] | ||
**[[Sickle cell disease]]: most common cause in children | **[[Sickle cell disease]]: most common cause in children | ||
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**upper [[urinary tract infection]] or [[pyelonephritis]] | **upper [[urinary tract infection]] or [[pyelonephritis]] | ||
**[[Tuberculosis]] | **[[Tuberculosis]] | ||
**[[liver cirrhosis]] | |||
** systemic [[vasculitis]] | ** systemic [[vasculitis]] | ||
**[[Renal]] [[transplant rejection]] | **[[Renal]] [[transplant rejection]] | ||
**chronic [[alcohol abuse]] | |||
**long term [[analgesics]] abuse such as [[acetaminophen]] and [[NSAIDS]] | **long term [[analgesics]] abuse such as [[acetaminophen]] and [[NSAIDS]] | ||
*** [[NSAIDS]] include: | *** [[NSAIDS]] include: | ||
| Line 27: | Line 30: | ||
****[[Piroxicam]] | ****[[Piroxicam]] | ||
****[[ketorolac]] | ****[[ketorolac]] | ||
**[[Renal papillary necrosis]] may also occur less commonly in [[infants]] due to<ref name="pmid4690507">{{cite journal| author=Husband P, Howlett KA| title=Renal papillary necrosis in infancy. | journal=Arch Dis Child | year= 1973 | volume= 48 | issue= 2 | pages= 116-20 | pmid=4690507 | doi=10.1136/adc.48.2.116 | pmc=1648192 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4690507 }} </ref>: | |||
***[[asphyxia]] | |||
***[[dehydration]] | |||
***[[sepsis]] | |||
==References== | ==References== | ||
Revision as of 21:39, 10 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]
Overview
- Renal papillary necrosis is associated with damaging the renal medullary and papillary cells due to many diseases such as diabetes, sickle cell disease, urinary tract obstruction, renal vein thrombosis, pyelonephritis, tuberculosis, vasculitis, cirrhosis, renal transplant rejection and long term analgesics and alcohol abuse. In infants, it is associated with asphyxia, dehydration, and sepsis.
Causes
- Common causes of renal papillary necrosis include[1][2][3]:
- Diabetes
- Sickle cell disease: most common cause in children
- Urinary tract obstruction
- Renal vein thrombosis
- upper urinary tract infection or pyelonephritis
- Tuberculosis
- liver cirrhosis
- systemic vasculitis
- Renal transplant rejection
- chronic alcohol abuse
- long term analgesics abuse such as acetaminophen and NSAIDS
- Renal papillary necrosis may also occur less commonly in infants due to[4]:
References
- ↑ Brix AE (2002). "Renal papillary necrosis". Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
- ↑ Sabatini S (1984). "Pathophysiology of drug-induced papillary necrosis". Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.
- ↑ Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D; et al. (2017). "Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis". J Pediatr Urol. 13 (3): 250–256. doi:10.1016/j.jpurol.2017.01.020. PMID 28341428.
- ↑ Husband P, Howlett KA (1973). "Renal papillary necrosis in infancy". Arch Dis Child. 48 (2): 116–20. doi:10.1136/adc.48.2.116. PMC 1648192. PMID 4690507.
[[Category:Disease]