Tetradecanoylphorbol-13-acetate response element gene transcriptions: Difference between revisions
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Activator protein 1 (AP-1) was first discovered as a 12-O-Tetradecanoylphorbol-13-acetate (TPA)-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa (hMTIIa) promoter and SV40.<ref name="Lee, Haslinger, Karin, Tjian">{{ cite journal | vauthors = Lee W, Haslinger A, Karin M, Tjian R | title = Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 | journal = Nature | volume = 325 | issue = 6102 | pages = 368–72 | date = January 1987 | pmid = 3027570 | doi = 10.1038/325368a0 | bibcode = 1987Natur.325..368L }}</ref> The AP-1 binding site was identified as the TPA response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’.<ref name="Angel, Imagawa, Chiu, Stein, Imbra, and coworkers">{{cite journal | vauthors = Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M | title = Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor | journal = Cell | volume = 49 | issue = 6 | pages = 729–39 | date = June 1987 | pmid = 3034432 | doi = 10.1016/0092-8674(87)90611-8 }}</ref> | Activator protein 1 (AP-1) was first discovered as a 12-O-Tetradecanoylphorbol-13-acetate (TPA)-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa (hMTIIa) promoter and SV40.<ref name="Lee, Haslinger, Karin, Tjian">{{ cite journal | vauthors = Lee W, Haslinger A, Karin M, Tjian R | title = Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 | journal = Nature | volume = 325 | issue = 6102 | pages = 368–72 | date = January 1987 | pmid = 3027570 | doi = 10.1038/325368a0 | bibcode = 1987Natur.325..368L }}</ref> The AP-1 binding site was identified as the TPA response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’.<ref name="Angel, Imagawa, Chiu, Stein, Imbra, and coworkers">{{cite journal | vauthors = Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M | title = Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor | journal = Cell | volume = 49 | issue = 6 | pages = 729–39 | date = June 1987 | pmid = 3034432 | doi = 10.1016/0092-8674(87)90611-8 }}</ref> | ||
==Consensus sequences== | |||
12-''O''-tetradecanoylphorbol-13-acetate (TPA) responsive element (TRE) (TGAGTCA).<ref name=Sato/> | |||
==Samplings== | |||
==See also== | ==See also== | ||
Revision as of 04:14, 24 August 2020
Activator protein 1 (AP-1) was first discovered as a 12-O-Tetradecanoylphorbol-13-acetate (TPA)-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa (hMTIIa) promoter and SV40.[1] The AP-1 binding site was identified as the TPA response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’.[2]
Consensus sequences
12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element (TRE) (TGAGTCA).[3]
Samplings
See also
References
- ↑ Lee W, Haslinger A, Karin M, Tjian R (January 1987). "Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40". Nature. 325 (6102): 368–72. Bibcode:1987Natur.325..368L. doi:10.1038/325368a0. PMID 3027570.
- ↑ Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (June 1987). "Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor". Cell. 49 (6): 729–39. doi:10.1016/0092-8674(87)90611-8. PMID 3034432.
- ↑ Invalid
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