Ataxia overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Ataxia''' (from Greek ''α-'' [used as a negative prefix] + ''-τάξις'' [order], meaning "lack of order") is a [[neurology|neurological]] sign and symptom consisting of gross incoordination of [[muscle]] movements. | '''Ataxia''' (from Greek ''α-'' [used as a negative prefix] + ''-τάξις'' [order], meaning "lack of order") is a [[neurology|neurological]] sign and symptom consisting of gross incoordination of [[muscle]] movements. Ataxia is an aspecific clinical manifestation implying dysfunction of parts of the [[nervous system]] that coordinate movement, such as the [[cerebellum]] <ref name="pmid27495205">{{cite journal |vauthors=Ashizawa T, Xia G |title=Ataxia |journal=Continuum (Minneap Minn) |volume=22 |issue=4 Movement Disorders |pages=1208–26 |date=August 2016 |pmid=27495205 |pmc=5567218 |doi=10.1212/CON.0000000000000362 |url=}}</ref> Several possible causes exist for these patterns of neurological dysfunction. The term "dystaxia" is rarely used as a synonym. | ||
Ataxia results from the involvement of cerebellar structures, or from a combination of cerebellar and extra-cerebellar lesions, especially the brainstem. Ataxia can be: | Ataxia results from the involvement of cerebellar structures, or from a combination of cerebellar and extra-cerebellar lesions, especially the brainstem. Ataxia can be of several types<ref name="pmid25432731">{{cite journal |vauthors=Akbar U, Ashizawa T |title=Ataxia |journal=Neurol Clin |volume=33 |issue=1 |pages=225–48 |date=February 2015 |pmid=25432731 |pmc=4251489 |doi=10.1016/j.ncl.2014.09.004 |url=}}</ref>: | ||
*'''Sporadic ataxias.''' Ataxias of this type usually begin in adulthood and have no known family history. | *'''Sporadic ataxias.''' Ataxias of this type usually begin in adulthood and have no known family history. | ||
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==References== | ==References== | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
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Revision as of 17:18, 24 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Ataxia (from Greek α- [used as a negative prefix] + -τάξις [order], meaning "lack of order") is a neurological sign and symptom consisting of gross incoordination of muscle movements. Ataxia is an aspecific clinical manifestation implying dysfunction of parts of the nervous system that coordinate movement, such as the cerebellum [1] Several possible causes exist for these patterns of neurological dysfunction. The term "dystaxia" is rarely used as a synonym.
Ataxia results from the involvement of cerebellar structures, or from a combination of cerebellar and extra-cerebellar lesions, especially the brainstem. Ataxia can be of several types[2]:
- Sporadic ataxias. Ataxias of this type usually begin in adulthood and have no known family history.
- Hereditary ataxias. These ataxias are caused by a defect in a gene that is present from the start of a person's life and can be either dominantly inherited or recessively inherited. Recessive disorders commonly cause symptoms to begin in childhood rather than in adulthood.
Risk Factors
- Viral infections, such as chickenpox , Coxsackie virus, Epstein-Barr, or HIV
- Bacterial infections such as Lyme disease
- Exposure to certain toxins, such as lead , mercury , thallium, alcohol , and organophosphates found in insecticides
- Cerebellar hemorrhage, abscess, blood clot, or obstruction of an artery
- Para-neoplastic syndromes—occurs when the immune system attacks the cerebellum in the area of a cancer
- Certain vaccinations.
Medical Therapy
There is no specific treatment for ataxia as such, altough there may be for the underlying cause. The disability of ataxia may be reduced by physical therapy, including exercises, along with leg braces or shoe splints. If foot alignment has been affected then a cane or walker is often used in the effort to prevent falls.
References
- ↑ Ashizawa T, Xia G (August 2016). "Ataxia". Continuum (Minneap Minn). 22 (4 Movement Disorders): 1208–26. doi:10.1212/CON.0000000000000362. PMC 5567218. PMID 27495205.
- ↑ Akbar U, Ashizawa T (February 2015). "Ataxia". Neurol Clin. 33 (1): 225–48. doi:10.1016/j.ncl.2014.09.004. PMC 4251489. PMID 25432731.