Sandbox:Javaria

History ❑Patient age may help determine age-specific causes, such as malignancy in elderly) ❑ Duration of symptoms (weeks in acute/severe versus years in chronic conditions) ❑ Past medical history suggestive of immunodeficiency (recurrent infections), diagnosed malignancy, malabsorption (chronic diarrhea), HF, dyspepsia ❑ Sexual history suggestive of HIV AIDS ❑ Family history of certain malignant disorders (breast cancer, ovarian cancer, colon cancer, or stomach cancer)) ❑ Exposure to communicable infectious diseases/ travel to high-risk areas ❑ Social history such as tobacco, alcohol use, opioid, cocaine use

Weight loss history ❑ Source of history: Patient or well-informed caregiver (elderly may be unaware or deny weight loss). ❑ Weight measurement records or best estimate of weight loss by the patient or caregiver (may be accessed by clothing size). ❑ Assess if the patient is nauseated or vomiting/ anorexia/ dysphagia/ odynophagia/ social reasons hindering food supply

Physical exam Appearance of the patient Cachexia or surgical scar marks demonstrating previous malignancy treatment ❑ Vital signs ❑ Temperature: High-grade / low-grade fever may demonstrate infection. ❑ Heart rate: Tachycardia with regular pulse may demonstrate infection. ❑ Respiratory rate: Tachypnea may demonstrate respiratory system involvement (infection\ metastasis). ❑ Blood pressure: Chronic hypertension or hypotension (may indicate sepsis as a complication). ❑ Oxygen saturation: may be low if the respiratory system is affected. ❑ HEENT ❑ Cardiovascular examination ❑ Respiratory examination ❑ Gastrointestinal system exam includes oral examination, abdominal examination, and digital rectal exam. ❑ Splenomegaly) may demonstrate IM, hodgkin's/ non-Hodgkin's lymphoma, and sarcoidosis ❑ Extremities exam ❑ Skin exam: Evaluate for the lesions that indicate malignancy such as melanoma/ potential inoculation sites for germ such as traumatic lesions.

Labs ❑ CBC with differential ❑ ESR ❑ CMP ❑ Peripheral smaer ❑ LFTs Labs may be required at a later stage pf diagnosis