Thin basement membrane disease history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Obtaining complete history both for the patient and family is an important aspect of diagnosing TBMD. The hallmark of TBMD is benign hematuria. A positive family | Obtaining complete [[History and Physical examination|history]] both for the patient and family is an important aspect of diagnosing [[TBMD]]. The hallmark of TBMD is [[Benign Recurrent Hamaturia|benign hematuria.]] A positive [[Family history|family histor]]<nowiki/>y of incidental finding of intermittent or [[Hematuria|persistent hematuria]] is suggestive of [[TBMD]]. TBMD is mostly asymptomatic. [[Microscopic hematuria]] is found incidentally. <ref name="pmid15327380">{{cite journal |vauthors=van Paassen P, van Breda Vriesman PJ, van Rie H, Tervaert JW |title=Signs and symptoms of thin basement membrane nephropathy: a prospective regional study on primary glomerular disease-The Limburg Renal Registry |journal=Kidney Int |volume=66 |issue=3 |pages=909–13 |date=September 2004 |pmid=15327380 |doi=10.1111/j.1523-1755.2004.00835.x |url=}}</ref> | ||
==History and Symptoms== | ==History and Symptoms== | ||
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===History=== | ===History=== | ||
Obtaining complete medical and family history is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of TBMD with Alport syndrome, IgA nephropathy, Lupus Nephritis and other glomerulopathies. History may be obtained focusing specific areas including: | Obtaining complete [[medical]] and [[family history]] is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of [[TBMD]] with [[Alport syndrome]], [[IgA nephropathy]], [[Lupus]] [[Nephritis]] and other [[Glomerulopathy|glomerulopathies.]] History may be obtained focusing specific areas including: | ||
*Past medical history including URTI, Autoimmune Disease, | |||
*Positive family history | *Past [[medical history]] including [[Upper respiratory infection|URTI]], [[Autoimmune disease|Autoimmune Disease]], [[Glomerulopathy|Glomerulopathi]]<nowiki/>es. | ||
*Physical properties of urine (color, turbidity). | *Positive [[family history]] o[[Benign Recurrent Hamaturia|f benign intermittent or persistent hematuria.]] | ||
*Nature of micturation (frequency, dysuria) | *[[Physical properties]] of [[urine]] ([[color]], [[turbidity]]). | ||
*New onset hypertension or edema. | *Nature of [[micturation]] ([[frequency]], [[dysuria]]) | ||
*New onset [[hypertension]] or [[edema]]. | |||
===Symptoms=== | ===Symptoms=== | ||
TBMD is mostly asymptomatic. The following signs are included: | TBMD is mostly asymptomatic. The following signs are included: | ||
*Intermiitent or persistent hematuria is found incidentally. | |||
*New onset hypertension. | *[[Benign Recurrent Hamaturia|Intermiitent or persistent hematuria]] is found incidentally. | ||
*Proteinuria. | *New onset [[hypertension]]. | ||
*Renal impairment. | *[[Proteinuria]]. | ||
*Renal failure. | *[[Renal impairment]]. | ||
*[[Renal failure]]. | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Obtaining complete history both for the patient and family is an important aspect of diagnosing TBMD. The hallmark of TBMD is benign hematuria. A positive family history of incidental finding of intermittent or persistent hematuria is suggestive of TBMD. TBMD is mostly asymptomatic. Microscopic hematuria is found incidentally. [1]
History and Symptoms
History
Obtaining complete medical and family history is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of TBMD with Alport syndrome, IgA nephropathy, Lupus Nephritis and other glomerulopathies. History may be obtained focusing specific areas including:
- Past medical history including URTI, Autoimmune Disease, Glomerulopathies.
- Positive family history of benign intermittent or persistent hematuria.
- Physical properties of urine (color, turbidity).
- Nature of micturation (frequency, dysuria)
- New onset hypertension or edema.
Symptoms
TBMD is mostly asymptomatic. The following signs are included:
- Intermiitent or persistent hematuria is found incidentally.
- New onset hypertension.
- Proteinuria.
- Renal impairment.
- Renal failure.
References
- ↑ van Paassen P, van Breda Vriesman PJ, van Rie H, Tervaert JW (September 2004). "Signs and symptoms of thin basement membrane nephropathy: a prospective regional study on primary glomerular disease-The Limburg Renal Registry". Kidney Int. 66 (3): 909–13. doi:10.1111/j.1523-1755.2004.00835.x. PMID 15327380.