Lymphadenopathy classification: Difference between revisions
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==Overview== | ==Overview== | ||
Lymphadenopathy may be classified according to distribution into 2 groups localized lymphadenopathy and generalized lymphadenopathy. | Lymphadenopathy may be classified according to distribution into 2 groups localized lymphadenopathy and generalized lymphadenopathy. | ||
Revision as of 17:23, 17 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2], Raviteja Guddeti, M.B.B.S. [3]Delband Yekta Moazami, M.D.[4]
Overview
Lymphadenopathy may be classified according to distribution into 2 groups localized lymphadenopathy and generalized lymphadenopathy.
Classification
Depending upon the involvement of the lymph nodes, lymphadenopathy is classified into 2 groups, generalized and localized:[1]
- Localized lymphadenopathy: localized adenopathy occurs in contiguous groupings of lymph nodes. In discrete anatomical regions, lymph nodes are distributed, and their enlargement represents their location's lymphatic drainage. Tender or non-tender, fixed or mobile, and discreet or "matted" together can be the nodes themselves. 75 percent of all lymphadenopathies are localized, with over 50% seen in the region of the head and neck.
- Generalized lymphadenopathy: generalized lymphadenopathy involves lymphadenopathy in 2 or more non-contiguous sites. due to generalized infection all over the body e.g. influenza.
- Persistent generalized lymphadenopathy (PGL): persisting for a long time, possibly without an apparent cause.
- Dermatopathic lymphadenopathy: lymphadenopathy associated with skin disease. Tangier disease (ABCA1 deficiency) may also cause this.
Lymphadenopathy may be classified as follows:
- By location:
- Dermatopathic lymphadenopathy: lymphadenopathy associated with skin disease.
- By malignancy: Benign lymphadenopathy is distinguished from malignant types which mainly refer to lymphomas or lymph node metastasis.
- By extent:
- Localized lymphadenopathy: due to localized spot of infection
- Generalized lymphadenopathy: due to systemic infection of the body. In some cases, it may persist for prolonged periods possibly without an apparent cause
- By size, where lymphadenopathy in adults is often defined as a short axis of one or more lymph nodes is greater than 10mm.[2][3]
References
- ↑ Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A (2014). "Peripheral lymphadenopathy: approach and diagnostic tools". Iran J Med Sci. 39 (2 Suppl): 158–70. PMC 3993046. PMID 24753638.
- ↑ Ganeshalingam S, Koh DM (December 2009). "Nodal staging". Cancer Imaging. 9: 104–11. doi:10.1102/1470-7330.2009.0017. PMC 2821588. PMID 20080453.
- ↑ Schmidt AF, Rodrigues OR, Matheus RS, Kim Jdu U, Jatene FB (2007). "Mediastinal lymph node distribution, size and number: definitions based on an anatomical study". J Bras Pneumol. 33 (2): 134–40. doi:10.1590/s1806-37132007000200006. PMID 17724531.