Sudden cardiac death pathophysiology: Difference between revisions
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(Created page with "__NOTOC__ {{Sudden cardiac death}} ==Overview== ==Pathopysiology==") |
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==Overview== | ==Overview== | ||
==Pathopysiology== | ==Pathopysiology== | ||
==Pathophysiology== | |||
*The pathogenesis of [[cardiac arrest]] is characterized by the myocardial inflammatory process in the setting of [[atherosclerosis]], [[structural heart disease]], [[genetic disorders]], and environmental factors. | |||
*The SCN5A, KCNH2, KCNQ1, RYR2, MYBPC3, PKP2, DSP genes mutation has been associated with the development of inherited causes of [[cardiac arrest]] and [[sudden cardiac death]].<ref name="OsmanTan2019">{{cite journal|last1=Osman|first1=Junaida|last2=Tan|first2=Shing Cheng|last3=Lee|first3=Pey Yee|last4=Low|first4=Teck Yew|last5=Jamal|first5=Rahman|title=Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers|journal=Journal of Biomedical Science|volume=26|issue=1|year=2019|issn=1423-0127|doi=10.1186/s12929-019-0535-8}}</ref><ref name="MehtaCurwin1997">{{cite journal|last1=Mehta|first1=Davendra|last2=Curwin|first2=Jay|last3=Gomes|first3=J. Anthony|last4=Fuster|first4=Valentin|title=Sudden Death in Coronary Artery Disease|journal=Circulation|volume=96|issue=9|year=1997|pages=3215–3223|issn=0009-7322|doi=10.1161/01.CIR.96.9.3215}}</ref><ref name="Akhtar1991">{{cite journal|last1=Akhtar|first1=Masood|title=Sudden Cardiac Death: Management of High-Risk Patients|journal=Annals of Internal Medicine|volume=114|issue=6|year=1991|pages=499|issn=0003-4819|doi=10.7326/0003-4819-114-6-499}}</ref> | |||
{{Family tree/start}} | |||
{{Family tree | | | | A01 |-| A02 |-|A03|-|A04| |A01= | |||
'''Structural and functional causes of [[sudden cardiac death]]''' | |||
* [[Coronary artery disease]] | |||
* [[Cardiomyopathy]] | |||
* [[Valvular heart disease]]<ref name="BassoPerazzolo Marra2015">{{cite journal|last1=Basso|first1=Cristina|last2=Perazzolo Marra|first2=Martina|last3=Rizzo|first3=Stefania|last4=De Lazzari|first4=Manuel|last5=Giorgi|first5=Benedetta|last6=Cipriani|first6=Alberto|last7=Frigo|first7=Anna Chiara|last8=Rigato|first8=Ilaria|last9=Migliore|first9=Federico|last10=Pilichou|first10=Kalliopi|last11=Bertaglia|first11=Emanuele|last12=Cacciavillani|first12=Luisa|last13=Bauce|first13=Barbara|last14=Corrado|first14=Domenico|last15=Thiene|first15=Gaetano|last16=Iliceto|first16=Sabino|title=Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death|journal=Circulation|volume=132|issue=7|year=2015|pages=556–566|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.115.016291}}</ref> | |||
* [[Congenital heart disease]] | |||
* [[Primary electrical abnormality]] | |||
* [[Channelopathy]]|A02= | |||
'''Trigger''' | |||
*[[Myocardial infarction]] | |||
*[[Myocardial ischemia]]/[[reperfusion]] | |||
*Emotional, physical stress | |||
*[[Hemodynamic decompensation]] | |||
*[[Electrolyte imbalance]] | |||
*[[Hypoxemia]],[[acidosis]] | |||
*[[Neurophysiological interactions]] | |||
*[[Drugs]]| | |||
A03='''[[Arrhythmia]] mechanism''' | |||
*[[Re-entry]] | |||
*[[Automaticity]] | |||
*[[Triggered activity]] | |||
*[[Conduction block]] | |||
*|A04= | |||
'''Fatal [[arrhythmia]]''' | |||
*Monomorphic [[ventricular tachycardia]] | |||
*Polymorphic [[ventricular tachycardia]] | |||
*[[Ventricular fibrillation]] | |||
*Profound [[bradycardia]] | |||
*[[Asystole]] | |||
*[[Pulseless electrical activity]]|}}| | |||
{{Family tree/end}} | |||
Revision as of 08:53, 2 February 2021
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Overview
Pathopysiology
Pathophysiology
- The pathogenesis of cardiac arrest is characterized by the myocardial inflammatory process in the setting of atherosclerosis, structural heart disease, genetic disorders, and environmental factors.
- The SCN5A, KCNH2, KCNQ1, RYR2, MYBPC3, PKP2, DSP genes mutation has been associated with the development of inherited causes of cardiac arrest and sudden cardiac death.[1][2][3]
| Structural and functional causes of sudden cardiac death | Trigger
| Arrhythmia mechanism
| Fatal arrhythmia
| ||||||||||||||||||||||||||||||||||||
- ↑ Osman, Junaida; Tan, Shing Cheng; Lee, Pey Yee; Low, Teck Yew; Jamal, Rahman (2019). "Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers". Journal of Biomedical Science. 26 (1). doi:10.1186/s12929-019-0535-8. ISSN 1423-0127.
- ↑ Mehta, Davendra; Curwin, Jay; Gomes, J. Anthony; Fuster, Valentin (1997). "Sudden Death in Coronary Artery Disease". Circulation. 96 (9): 3215–3223. doi:10.1161/01.CIR.96.9.3215. ISSN 0009-7322.
- ↑ Akhtar, Masood (1991). "Sudden Cardiac Death: Management of High-Risk Patients". Annals of Internal Medicine. 114 (6): 499. doi:10.7326/0003-4819-114-6-499. ISSN 0003-4819.
- ↑ Basso, Cristina; Perazzolo Marra, Martina; Rizzo, Stefania; De Lazzari, Manuel; Giorgi, Benedetta; Cipriani, Alberto; Frigo, Anna Chiara; Rigato, Ilaria; Migliore, Federico; Pilichou, Kalliopi; Bertaglia, Emanuele; Cacciavillani, Luisa; Bauce, Barbara; Corrado, Domenico; Thiene, Gaetano; Iliceto, Sabino (2015). "Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death". Circulation. 132 (7): 556–566. doi:10.1161/CIRCULATIONAHA.115.016291. ISSN 0009-7322.