Metabolic acidosis future or investigational therapies: Difference between revisions
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==== <u><big>Experimental Treatment:</big></u> ==== | |||
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows: | |||
# Dichloroacetate | |||
# Administration of selective inhibitors Na+-H+ Exchanger 1 or amilonde analogues | |||
# Administration of inhibitors of transient receptor potential vanilloid 1 | |||
# Administration of selective inhibitors acid sensing Ion channel la | |||
# Administration of inhibitors of mitogen activated protein kinase | |||
==References== | ==References== | ||
Revision as of 18:01, 11 February 2021
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Resident Survival Guide |
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Metabolic acidosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Experimental Treatment:
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:
- Dichloroacetate
- Administration of selective inhibitors Na+-H+ Exchanger 1 or amilonde analogues
- Administration of inhibitors of transient receptor potential vanilloid 1
- Administration of selective inhibitors acid sensing Ion channel la
- Administration of inhibitors of mitogen activated protein kinase