Diabetic foot natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
If left untreated diabetic ulcer may progress to infection, sepsis, or osteomyelitis. According to an estimate 20% of significant diabetic foot ulcers end up requiring an amputation. Untreated diabetic foot ulcer cab lead to death of the affected individual.<ref name="pmid28614678">{{cite journal| author=Armstrong DG, Boulton AJM, Bus SA| title=Diabetic Foot Ulcers and Their Recurrence. | journal=N Engl J Med | year= 2017 | volume= 376 | issue= 24 | pages= 2367-2375 | pmid=28614678 | doi=10.1056/NEJMra1615439 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28614678 }} </ref> | *[[Diabetic foot]] as a known [[Complication (medicine)|complication]] of [[diabetes]] is more related to [[diabetes|diabetes mellitus type 2]], compared to [[diabetes|type 1 diabetes]].<ref name="pmid27585063">{{cite journal| author=Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y| title=Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis †. | journal=Ann Med | year= 2017 | volume= 49 | issue= 2 | pages= 106-116 | pmid=27585063 | doi=10.1080/07853890.2016.1231932 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27585063 }} </ref><ref name="pmid23124278">{{cite journal| author=Moura Neto A, Zantut-Wittmann DE, Fernandes TD, Nery M, Parisi MC| title=Risk factors for ulceration and amputation in diabetic foot: study in a cohort of 496 patients. | journal=Endocrine | year= 2013 | volume= 44 | issue= 1 | pages= 119-24 | pmid=23124278 | doi=10.1007/s12020-012-9829-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23124278 }} </ref> | ||
*If left untreated diabetic ulcer may progress to infection, sepsis, or osteomyelitis. According to an estimate 20% of significant diabetic foot ulcers end up requiring an amputation. Untreated diabetic foot ulcer cab lead to death of the affected individual.<ref name="pmid28614678">{{cite journal| author=Armstrong DG, Boulton AJM, Bus SA| title=Diabetic Foot Ulcers and Their Recurrence. | journal=N Engl J Med | year= 2017 | volume= 376 | issue= 24 | pages= 2367-2375 | pmid=28614678 | doi=10.1056/NEJMra1615439 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28614678 }} </ref> | |||
==Complications== | ==Complications== | ||
Revision as of 09:42, 27 February 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vishnu Vardhan Serla M.B.B.S. [2] Usama Talib, BSc, MD [3]
Overview
Patients with diabetic foot have an increased risk of all-cause mortality, especially cardiovascular disorders, compared with patients with diabetes without a history of diabetic foot ulcer. The complications of diabetic foot ulcers include infection, sepsis, osteomyelitis and death.[1][2]
Natural History
- Diabetic foot as a known complication of diabetes is more related to diabetes mellitus type 2, compared to type 1 diabetes.[3][4]
- If left untreated diabetic ulcer may progress to infection, sepsis, or osteomyelitis. According to an estimate 20% of significant diabetic foot ulcers end up requiring an amputation. Untreated diabetic foot ulcer cab lead to death of the affected individual.[2]
Complications
Diabetic foot ulcer can cause many complications including:[2]
- Infection
- Sepsis
- Osteomyelitis
- Gangrene
- Lower limb amputation
- It is estimated that roughly half of non traumatic lower limb amputation is due to diabetic foot in North America and Europe.
- Death
Prognosis
- If left untreated prognosis could be very bad and it eventually can lead to death.[2]
- The 5 year risk of mortality in diabetic patients with a foot ulcer is 2.5 times higher than diabetic individuals without a foot ulcer.[2]
References
- ↑ Brownrigg JR, Davey J, Holt PJ, Davis WA, Thompson MM, Ray KK; et al. (2012). "The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis". Diabetologia. 55 (11): 2906–12. doi:10.1007/s00125-012-2673-3. PMID 22890823.
- ↑ 2.0 2.1 2.2 2.3 2.4 Armstrong DG, Boulton AJM, Bus SA (2017). "Diabetic Foot Ulcers and Their Recurrence". N Engl J Med. 376 (24): 2367–2375. doi:10.1056/NEJMra1615439. PMID 28614678.
- ↑ Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y (2017). "Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis †". Ann Med. 49 (2): 106–116. doi:10.1080/07853890.2016.1231932. PMID 27585063.
- ↑ Moura Neto A, Zantut-Wittmann DE, Fernandes TD, Nery M, Parisi MC (2013). "Risk factors for ulceration and amputation in diabetic foot: study in a cohort of 496 patients". Endocrine. 44 (1): 119–24. doi:10.1007/s12020-012-9829-2. PMID 23124278.