Lymphadenopathy laboratory findings: Difference between revisions
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==Laboratory findings== | ==Laboratory findings== | ||
*Laboratory findings consistent with the diagnosis of [[lymphadenopathy]] | *Laboratory findings consistent with the diagnosis of [[lymphadenopathy]] may include:<ref name="pmid24753638">{{cite journal |vauthors=Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A |title=Peripheral lymphadenopathy: approach and diagnostic tools |journal=Iran J Med Sci |volume=39 |issue=2 Suppl |pages=158–70 |year=2014 |pmid=24753638 |pmc=3993046 |doi= |url=}}</ref><ref name="pmid30020622">{{cite journal |vauthors=Freeman AM, Matto P |title= |journal= |volume= |issue= |pages= |date= |pmid=30020622 |doi= |url=}}</ref> | ||
'''Complete Blood Count''' | '''Complete Blood Count''' | ||
:*Elevated [[lactate dehydrogenase]] (LDH) | :*Elevated [[lactate dehydrogenase]] (LDH) | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]Delband Yekta Moazami, M.D.[3]
Overview
CBC with differential is a simple test and basic screening for regional and generalized lymphadenopathy. Bacterial, viral, or fungal pathology may be suggested by the number and differentiation of white blood cells. Furthermore, with many hematological neoplasms causing lymphadenopathy, typical white blood cell (WBC) trends are observed.
Laboratory findings
- Laboratory findings consistent with the diagnosis of lymphadenopathy may include:[1][2]
Complete Blood Count
- Elevated lactate dehydrogenase (LDH)
- Mild neutropenia
- Leukocytosis
- Elevated markers of inflammation and acute phase reactants (e.g. ESR,C-reactive protein, ferritin)
- CBC with manual differential: CBC with differential is a simple test and basic screening for regional and generalized lymphadenopathy. Bacterial, viral, or fungal pathology may be suggested by the number and differentiation of white blood cells. Furthermore, with many hematological neoplasms causing lymphadenopathy, typical white blood cell (WBC) trends are observed.
- EBV serology: Epstein-Barr viral mono is present causing regionalized lymphadenopathy
- Sedimentation rate: A measure of inflammation though not diagnostic, can contribute to diagnostic reasoning
- Cytomegalovirus titers: This viral serology is indicative of possible CMV mononucleosis
- HIV serology: This serology can be used to diagnose acute HIV syndrome-related lymphadenopathy or to infer the diagnosis of secondary HIV-elated pathologies causing lymphadenopathy.
- Bartonella henselae serology: used for the diagnosis of cat-scratch lymphadenopathy
- FTA\RPR: These tests can diagnose syphilis as the cause of lymphadenopathy
- Herpes simplex serology: can determine if the lymphadenopathy is herpes-related. Herpes simplex can produce symptoms that are similar to mononucleosis.
- Toxoplasmosis serology: can be used to diagnose toxoplasmosis
- Hepatitis B serology: Serological tests for hepatitis B to establish it as a contributing factor for lymphadenopathy
- ANA: this is a screening test for SLE that can help establish it as a cause for generalized lymphadenopathy