Herpes simplex orofacial infection: Difference between revisions
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==Associated Conditions== | |||
*[[Leukemia|Leukemia]]:<ref name="pmid3515270">{{cite journal| author=Barrett AP| title=A long-term prospective clinical study of orofacial herpes simplex virus infection in acute leukemia. | journal=Oral Surg Oral Med Oral Pathol | year= 1986 | volume= 61 | issue= 2 | pages= 149-52 | pmid=3515270 | doi=10.1016/0030-4220(86)90177-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3515270 }} </ref> | |||
**[[Herpes simplex orofacial infection]] has been reported in 40% of [[patients]] with [[Leukemia|acute leukemia]]. | |||
==Treatment== | ==Treatment== | ||
*Based on a [[Blind experiment|double-blind]], [[Placebo-controlled studies|placebo controlled]], [[Randomized controlled trial|randomized trial]] done on [[patients]] with recurrent [[herpes simplex orofacial infection]] showed efficacy of 5% [[Acyclovir (ointment)|acyclovir cream]] containing propylene glycol in reducing the period of [[vesicle|vesiculation]] (P = 0.016), healing time (P = 0.022) and [[itch|itching]] duration.<ref name="pmid6355055">{{cite journal| author=Van Vloten WA, Swart RN, Pot F| title=Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. | journal=J Antimicrob Chemother | year= 1983 | volume= 12 Suppl B | issue= | pages= 89-93 | pmid=6355055 | doi=10.1093/jac/12.suppl_b.89 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6355055 }} </ref> | *Based on a [[Blind experiment|double-blind]], [[Placebo-controlled studies|placebo controlled]], [[Randomized controlled trial|randomized trial]] done on [[patients]] with recurrent [[herpes simplex orofacial infection]] showed efficacy of 5% [[Acyclovir (ointment)|acyclovir cream]] containing propylene glycol in reducing the period of [[vesicle|vesiculation]] (P = 0.016), healing time (P = 0.022) and [[itch|itching]] duration.<ref name="pmid6355055">{{cite journal| author=Van Vloten WA, Swart RN, Pot F| title=Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. | journal=J Antimicrob Chemother | year= 1983 | volume= 12 Suppl B | issue= | pages= 89-93 | pmid=6355055 | doi=10.1093/jac/12.suppl_b.89 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6355055 }} </ref> <ref name="pmid3515270">{{cite journal| author=Barrett AP| title=A long-term prospective clinical study of orofacial herpes simplex virus infection in acute leukemia. | journal=Oral Surg Oral Med Oral Pathol | year= 1986 | volume= 61 | issue= 2 | pages= 149-52 | pmid=3515270 | doi=10.1016/0030-4220(86)90177-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3515270 }} </ref> | ||
==References== | ==References== |
Revision as of 17:30, 16 May 2021
Herpesviral vesicular dermatitis | |
Herpes lesion on upper lip and face |
Herpes simplex Microchapters |
Patient Information |
Classification |
Herpes simplex orofacial infection On the Web |
Risk calculators and risk factors for Herpes simplex orofacial infection |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
- Infection by HSV-1 is the most common cause of herpes that affects the face and mouth (orofacial herpes), although within the recent years an increase in oral HSV-2 infections has been reported.[1]
Clinical Presentations
- A majority of primary HSV-1 infections occur during childhood and if the virus comes into contact with the mucosa or abraded skin, it can cause acute herpetic gingivostomatitis (inflammation of the cheek's mucosa and gums) within 5–10 days. Some other symptoms may also develop, including fever and sore throat, and painful ulcers may appear.[1]
- Prodromal symptoms often precede a recurrence, which typically begins with reddening of the skin around the infected site, with eventual ulceration to form fluid-filled blisters that affect the lip (labial) tissue and the area between the lip and skin (vermillion border).[1] [2]
- Primary HSV infection in adolescents frequently manifests as severe pharyngitis with lesions developing on the cheek and gums. Some individuals develop difficulty in swallowing (dysphagia) and swollen lymph nodes (lymphadenopathy).[1] Primary HSV infections in adults often presents as pharyngitis similar to that observed in glandular fever (infectious mononucleosis), but gingivostomatitis is less likely. The symptoms of primary HSV infection generally resolve within two weeks.[1]
Disease Progression And Recurrence
- Once a primary oral HSV-1 infection has resolved, the HSV enters the nerves surrounding the primary lesion, migrates to the cell body of the neuron, and becomes latent in the trigeminal ganglion. In some patients, the virus reactivates to cause recurrent infection; which is more common with HSV-1 than HSV-2 oral infection.[1] [3]
- The recurrent infection is thus often called herpes simplex labialis. Rare occasions of reinfections occur inside the mouth (intraoral HSV stomatitis), affecting the gums, alveolar ridge, hard palate, and the back of the tongue. This may be accompanied by herpes labialis.[1] [4]
- Oral herpes is spread by direct contact with an active sore in an infected person, for instance, by kissing. However, the virus can be transmitted through the skin in the absence of a lesion.
- Oral herpes and cold sores can sometimes be confused with canker sores.
Differential diagnosis
Herpes simplex orofacial infection must be differentiated from other diseases causing oral lesions such as leukoplakia and herpes simplex virus infection.[5]
Disease | Presentation | Risk Factors | Diagnosis | Affected Organ Systems | Important features | Picture |
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Diseases predominantly affecting the oral cavity | ||||||
Oral Candidiasis |
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Localized candidiasis
Invasive candidasis |
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Herpes simplex oral lesions | ||||||
Aphthous ulcers |
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Squamous cell carcinoma |
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Leukoplakia |
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Melanoma |
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Fordyce spots |
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Burning mouth syndrome |
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Torus palatinus |
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Diseases involving oral cavity and other organ systems | ||||||
Behcet's disease |
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Crohn's disease |
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Agranulocytosis |
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Syphilis[8] |
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Coxsackie virus |
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Chicken pox |
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Measles |
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Associated Conditions
- Leukemia:[11]
- Herpes simplex orofacial infection has been reported in 40% of patients with acute leukemia.
Treatment
- Based on a double-blind, placebo controlled, randomized trial done on patients with recurrent herpes simplex orofacial infection showed efficacy of 5% acyclovir cream containing propylene glycol in reducing the period of vesiculation (P = 0.016), healing time (P = 0.022) and itching duration.[12] [11]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Bruce AJ, Rogers RS (2004) Oral manifestations of sexually transmitted diseases. Clin Dermatol 22 (6):520-7. DOI:10.1016/j.clindermatol.2004.07.005 PMID: 15596324
- ↑ Herpes Online: Exploring the "H" Community, pages 1-4 American Social Health Association 1996 Access date: 2007-03-29
- ↑ Herpes Online: Exploring the "H" Community, pages 1-4 American Social Health Association 1996 Access date: 2007-03-29
- ↑ Herpes Online: Exploring the "H" Community, pages 1-4 American Social Health Association 1996 Access date: 2007-03-29
- ↑ Scully C (1989). "Orofacial herpes simplex virus infections: current concepts in the epidemiology, pathogenesis, and treatment, and disorders in which the virus may be implicated". Oral Surg Oral Med Oral Pathol. 68 (6): 701–10. doi:10.1016/0030-4220(89)90159-x. PMID 2556674.
- ↑ Ann M. Gillenwater, Nadarajah Vigneswaran, Hanadi Fatani, Pierre Saintigny & Adel K. El-Naggar (2013). "Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity!". Advances in anatomic pathology. 20 (6): 416–423. doi:10.1097/PAP.0b013e3182a92df1. PMID 24113312. Unknown parameter
|month=
ignored (help) - ↑ Andrès E, Zimmer J, Affenberger S, Federici L, Alt M, Maloisel F. (2006). "Idiosyncratic drug-induced agranulocytosis: Update of an old disorder". Eur J Intern Med. 17 (8): 529–35. Text "pmid 17142169" ignored (help)
- ↑ title="By Internet Archive Book Images [No restrictions], via Wikimedia Commons" href="https://commons.wikimedia.org/wiki/File:A_manual_of_syphilis_and_the_venereal_diseases%2C_(1900)_(14595882378).jpg"
- ↑ Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE (2000). "Individual and community risks of measles and pertussis associated with personal exemptions to immunization". JAMA. 284 (24): 3145–50. PMID 11135778.
- ↑ Ratnam S, West R, Gadag V, Williams B, Oates E (1996). "Immunity against measles in school-aged children: implications for measles revaccination strategies". Can J Public Health. 87 (6): 407–10. PMID 9009400.
- ↑ 11.0 11.1 Barrett AP (1986). "A long-term prospective clinical study of orofacial herpes simplex virus infection in acute leukemia". Oral Surg Oral Med Oral Pathol. 61 (2): 149–52. doi:10.1016/0030-4220(86)90177-5. PMID 3515270.
- ↑ Van Vloten WA, Swart RN, Pot F (1983). "Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections". J Antimicrob Chemother. 12 Suppl B: 89–93. doi:10.1093/jac/12.suppl_b.89. PMID 6355055.