Back pain pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
*[[Lumbar disc disease]] have been linked to [[genetic]] involvment. The risk of developing [[lumbar disc disease]] increases if found in other close relatives. | *[[Lumbar disc disease]] have been linked to [[genetic]] involvment. The risk of developing [[lumbar disc disease]] increases if found in other close relatives. | ||
*[[Genes]] involved in the pathogenesis of [[back]] [[pain]] include: | *[[Genes]] involved in the pathogenesis of [[back]] [[pain]] include:<ref name="pmid30261039">{{cite journal| author=Suri P, Palmer MR, Tsepilov YA, Freidin MB, Boer CG, Yau MS | display-authors=etal| title=Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. | journal=PLoS Genet | year= 2018 | volume= 14 | issue= 9 | pages= e1007601 | pmid=30261039 | doi=10.1371/journal.pgen.1007601 | pmc=6159857 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30261039 }} </ref> | ||
**SOX5 | **SOX5 | ||
**CCDC26/GSDMC | **CCDC26/GSDMC | ||
Revision as of 14:46, 18 May 2021
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Back pain Microchapters |
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Back pain pathophysiology On the Web |
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Risk calculators and risk factors for Back pain pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]
Overview
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
- The exact pathogenesis of back pain depends on the underlying cause.
- Back pain can be broadly classified into inflammatory, mechanical, degenerative, oncologic and infectious.[1][2][3][4]
| Type of back pain | Pathophysiology |
| Inflammatory | Inflammation of joints (sacroiliitis), inflammation of enthesis (spondyloarthritis) |
| Mechanical | Trauma, muscle sprain, extra weight on muscles (pregnancy, heavy lifting), |
| Oncologic | Lytic lesions in spine, nerve compression due to mass effect, pathologic fracture due to weakened bone |
| Degenerative | Cartilage degradation and bone remodeling decreases elasticity and causes pain , fractures can also occur due to osteoporosis, |
| Infectious | Infection involving spine, disc, joints, abscess formation. |
Genetics
- Lumbar disc disease have been linked to genetic involvment. The risk of developing lumbar disc disease increases if found in other close relatives.
- Genes involved in the pathogenesis of back pain include:[5]
- SOX5
- CCDC26/GSDMC
- DCC
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Patrick N, Emanski E, Knaub MA (2014). "Acute and chronic low back pain". Med Clin North Am. 98 (4): 777–89, xii. doi:10.1016/j.mcna.2014.03.005. PMID 24994051.
- ↑ Goode AP, Carey TS, Jordan JM (2013). "Low back pain and lumbar spine osteoarthritis: how are they related?". Curr Rheumatol Rep. 15 (2): 305. doi:10.1007/s11926-012-0305-z. PMC 3606549. PMID 23307577.
- ↑ Ross MD, Bayer E (2005). "Cancer as a cause of low back pain in a patient seen in a direct access physical therapy setting". J Orthop Sports Phys Ther. 35 (10): 651–8. doi:10.2519/jospt.2005.35.10.651. PMID 16294986.
- ↑ Chien JJ, Bajwa ZH (2008). "What is mechanical back pain and how best to treat it?". Curr Pain Headache Rep. 12 (6): 406–11. doi:10.1007/s11916-008-0069-3. PMID 18973732.
- ↑ Suri P, Palmer MR, Tsepilov YA, Freidin MB, Boer CG, Yau MS; et al. (2018). "Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain". PLoS Genet. 14 (9): e1007601. doi:10.1371/journal.pgen.1007601. PMC 6159857. PMID 30261039.