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| Line 25: |
Line 25: |
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| ==[[Autoimmune lymphoproliferative syndrome historical perspective|Historical Perspective]]== | | ==[[Autoimmune lymphoproliferative syndrome historical perspective|Historical Perspective]]== |
|
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| ==Discovery==
| |
| <br />
| |
|
| |
| ==Overview==
| |
| The exact pathogenesis of [disease name] is not fully understood.
| |
|
| |
| OR
| |
|
| |
| It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
| |
|
| |
| OR
| |
|
| |
| [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
| |
|
| |
| OR
| |
|
| |
| Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
| |
|
| |
| OR
| |
|
| |
| [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
| |
|
| |
| OR
| |
|
| |
| The progression to [disease name] usually involves the [molecular pathway].
| |
|
| |
| OR
| |
|
| |
| The pathophysiology of [disease/malignancy] depends on the histological subtype.
| |
|
| |
| ==Pathophysiology==
| |
|
| |
| ===Physiology===
| |
| The normal physiology of [name of process] can be understood as follows:
| |
|
| |
| ===Pathogenesis===
| |
|
| |
| *The exact pathogenesis of [disease name] is not completely understood.
| |
|
| |
| OR
| |
|
| |
| *It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
| |
| *[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
| |
| *Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
| |
| *[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
| |
| *The progression to [disease name] usually involves the [molecular pathway].
| |
| *The pathophysiology of [disease/malignancy] depends on the histological subtype.
| |
|
| |
| ==Genetics==
| |
| [Disease name] is transmitted in [mode of genetic transmission] pattern.
| |
|
| |
| OR
| |
|
| |
| Genes involved in the pathogenesis of [disease name] include:
| |
|
| |
| *[Gene1]
| |
| *[Gene2]
| |
| *[Gene3]
| |
|
| |
| OR
| |
|
| |
| The development of [disease name] is the result of multiple genetic mutations such as:
| |
|
| |
| *[Mutation 1]
| |
| *[Mutation 2]
| |
| *[Mutation 3]
| |
|
| |
| ==Associated Conditions==
| |
| Conditions associated with [disease name] include:
| |
|
| |
| *[Condition 1]
| |
| *[Condition 2]
| |
| *[Condition 3]
| |
|
| |
| ==Gross Pathology==
| |
| On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==Microscopic Pathology==
| |
| On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==References==
| |
|
| |
|
| ==[[Autoimmune lymphoproliferative syndrome classification|Classification]]== | | ==[[Autoimmune lymphoproliferative syndrome classification|Classification]]== |
| <br />
| |
|
| |
| ==Overview==
| |
| There is no established system for the classification of [disease name].
| |
|
| |
| OR
| |
|
| |
| [Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
| |
|
| |
| OR
| |
|
| |
| [Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
| |
|
| |
| OR
| |
|
| |
| Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
| |
|
| |
| OR
| |
|
| |
| If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
| |
|
| |
| OR
| |
|
| |
| The staging of [malignancy name] is based on the [staging system].
| |
|
| |
| OR
| |
|
| |
| There is no established system for the staging of [malignancy name].
| |
|
| |
| ==Classification==
| |
| There is no established system for the classification of [disease name].
| |
|
| |
| OR
| |
|
| |
| [Disease name] may be classified according to [classification method] into [number] subtypes/groups:
| |
|
| |
| *[Group1]
| |
| *[Group2]
| |
| *[Group3]
| |
| *[Group4]
| |
|
| |
| OR
| |
|
| |
| [Disease name] may be classified into [large number > 6] subtypes based on:
| |
|
| |
| *[Classification method 1]
| |
| *[Classification method 2]
| |
| *[Classification method 3]
| |
|
| |
| [Disease name] may be classified into several subtypes based on:
| |
|
| |
| *[Classification method 1]
| |
| *[Classification method 2]
| |
| *[Classification method 3]
| |
|
| |
| OR
| |
|
| |
| Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
| |
|
| |
| OR
| |
|
| |
| '''If the staging system involves specific and characteristic findings and features:'''
| |
|
| |
| According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
| |
|
| |
| OR
| |
|
| |
| The staging of [malignancy name] is based on the [staging system].
| |
|
| |
| OR
| |
|
| |
| There is no established system for the staging of [malignancy name].
| |
|
| |
| ==References==
| |
|
| |
| ==[[Autoimmune lymphoproliferative syndrome pathophysiology|Pathophysiology]]== | | ==[[Autoimmune lymphoproliferative syndrome pathophysiology|Pathophysiology]]== |
| <br />
| |
|
| |
| ==Overview==
| |
| The exact pathogenesis of [disease name] is not fully understood.
| |
|
| |
| OR
| |
|
| |
| It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
| |
|
| |
| OR
| |
|
| |
| [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
| |
|
| |
| OR
| |
|
| |
| Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
| |
|
| |
| OR
| |
|
| |
| [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
| |
|
| |
| OR
| |
|
| |
| The progression to [disease name] usually involves the [molecular pathway].
| |
|
| |
| OR
| |
|
| |
| The pathophysiology of [disease/malignancy] depends on the histological subtype.
| |
|
| |
| ==Pathophysiology==
| |
|
| |
| ===Physiology===
| |
| The normal physiology of [name of process] can be understood as follows:
| |
|
| |
| ===Pathogenesis===
| |
|
| |
| *The exact pathogenesis of [disease name] is not completely understood.
| |
|
| |
| OR
| |
|
| |
| *It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
| |
| *[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
| |
| *Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
| |
| *[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
| |
| *The progression to [disease name] usually involves the [molecular pathway].
| |
| *The pathophysiology of [disease/malignancy] depends on the histological subtype.
| |
|
| |
| ==Genetics==
| |
| [Disease name] is transmitted in [mode of genetic transmission] pattern.
| |
|
| |
| OR
| |
|
| |
| Genes involved in the pathogenesis of [disease name] include:
| |
|
| |
| *[Gene1]
| |
| *[Gene2]
| |
| *[Gene3]
| |
|
| |
| OR
| |
|
| |
| The development of [disease name] is the result of multiple genetic mutations such as:
| |
|
| |
| *[Mutation 1]
| |
| *[Mutation 2]
| |
| *[Mutation 3]
| |
|
| |
| ==Associated Conditions==
| |
| Conditions associated with [disease name] include:
| |
|
| |
| *[Condition 1]
| |
| *[Condition 2]
| |
| *[Condition 3]
| |
|
| |
| ==Gross Pathology==
| |
| On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==Microscopic Pathology==
| |
| On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
| |
|
| |
| ==References==
| |
|
| |
| ==[[Autoimmune lymphoproliferative syndrome causes|Causes]]== | | ==[[Autoimmune lymphoproliferative syndrome causes|Causes]]== |
| <br />
| |
|
| |
| ==Overview[edit | edit source]==
| |
| Disease name] may be caused by [cause1], [cause2], or [cause3].
| |
|
| |
| OR
| |
|
| |
| Common causes of [disease] include [cause1], [cause2], and [cause3].
| |
|
| |
| OR
| |
|
| |
| The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
| |
|
| |
| OR
| |
|
| |
| The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
| |
|
| |
| ==Causes[edit | edit source]==
| |
|
| |
| *ymptom/manifestation] include [cause1], [cause2], and [cause3].
| |
| *[Cause] is a life-threatening cause of [disease].
| |
|
| |
| ===Common Causes[edit | edit source]===
| |
| Common causes of [disease name] may include:
| |
|
| |
| *[Cause1]
| |
| *[Cause2]
| |
| *[Cause3]
| |
|
| |
| OR
| |
|
| |
| *[Disease name] is caused by an infection with [pathogen name].
| |
| *[Pathogen name] is caused by [pathogen name].
| |
|
| |
| ===Less Common Causes[edit | edit source]===
| |
| Less common causes of [disease name] include:
| |
|
| |
| *[Cause1]
| |
| *[Cause2]
| |
| *[CauseCauses by OrganList the causes of the disease in alphabetical order:
| |
| *Cause 1
| |
| *Cause 2
| |
| *Cause 3
| |
| *Cause 4
| |
| *Cause 5
| |
| *Cause 6
| |
| *Cause 7
| |
| *Cause 8
| |
| *Cause 9
| |
| *Cause 10
| |
|
| |
| ==References==
| |
|
| |
| ==[[Autoimmune lymphoproliferative syndrome differential diagnosis|Differentiating Autoimmune lymphoproliferative syndrome from other Diseases]]== | | ==[[Autoimmune lymphoproliferative syndrome differential diagnosis|Differentiating Autoimmune lymphoproliferative syndrome from other Diseases]]== |
| <br />
| |
|
| |
| ==Overview==
| |
| [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
| |
|
| |
| OR
| |
|
| |
| [Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
| |
|
| |
| ==Differentiating [Disease name] from other Diseases==
| |
| [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
| |
|
| |
| OR
| |
|
| |
| [Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].
| |
|
| |
| OR
| |
|
| |
| As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].
| |
|
| |
| ===Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]===
| |
| On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].
| |
| {| class="wikitable"
| |
| ! rowspan="4" |Diseases
| |
| | colspan="6" rowspan="1" |'''Clinical manifestations'''
| |
| ! colspan="7" rowspan="2" |Para-clinical findings
| |
| | colspan="1" rowspan="4" |'''Gold standard'''
| |
| ! rowspan="4" |Additional findings
| |
| |-
| |
| | colspan="3" rowspan="2" |'''Symptoms'''
| |
| ! colspan="3" rowspan="2" |Physical examination
| |
| |-
| |
| ! colspan="3" |Lab Findings
| |
| ! colspan="3" |Imaging
| |
| ! rowspan="2" |Histopathology
| |
| |-
| |
| !Symptom 1
| |
| ! colspan="1" rowspan="1" |Symptom 2
| |
| !Symptom 3
| |
| !Physical exam 1
| |
| ! colspan="1" rowspan="1" |Physical exam 2
| |
| !Physical exam 3
| |
| !Lab 1
| |
| !Lab 2
| |
| !Lab 3
| |
| !Imaging 1
| |
| !Imaging 2
| |
| !Imaging 3
| |
| |-
| |
| |Differential Diagnosis 1
| |
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| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |Differential Diagnosis 2
| |
| |
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| |
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| |
| |
| |
| |
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| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |Differential Diagnosis 3
| |
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| |
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| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| !Diseases
| |
| !Symptom 1
| |
| ! colspan="1" rowspan="1" |Symptom 2
| |
| !Symptom 3
| |
| !Physical exam 1
| |
| ! colspan="1" rowspan="1" |Physical exam 2
| |
| !Physical exam 3
| |
| !Lab 1
| |
| !Lab 2
| |
| !Lab 3
| |
| !Imaging 1
| |
| !Imaging 2
| |
| !Imaging 3
| |
| !Histopathology
| |
| |'''Gold standard'''
| |
| !Additional findings
| |
| |-
| |
| |Differential Diagnosis 4
| |
| |
| |
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| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |Differential Diagnosis 5
| |
| |
| |
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| |
| |
| |
| |
| |
| |
| |
| |
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| |
| |
| |
| |
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| |
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| |
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| |
| |
| |
| |
| |
| |
| |-
| |
| |Differential Diagnosis 6
| |
| |
| |
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| |
| |
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| |
| |}
| |
|
| |
| ==References==
| |
|
| |
| ==[[Autoimmune lymphoproliferative syndrome epidemiology and demographics|Epidemiology and Demographics]]== | | ==[[Autoimmune lymphoproliferative syndrome epidemiology and demographics|Epidemiology and Demographics]]== |
|
| |
| ==Overview==
| |
|
| |
| ==Epidemiology and Demographics==
| |
|
| |
| ===Incidence===
| |
|
| |
| *The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
| |
| *In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
| |
|
| |
| ===Prevalence===
| |
|
| |
| *The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
| |
| *In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
| |
| *The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
| |
|
| |
| ===Case-fatality rate/Mortality rate===
| |
|
| |
| *In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
| |
| *The case-fatality rate/mortality rate of [disease name] is approximately [number range].
| |
|
| |
| ===Age===
| |
|
| |
| *Patients of all age groups may develop [disease name].
| |
| *The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
| |
| *[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
| |
| *[Chronic disease name] is usually first diagnosed among [age group].
| |
| *[Acute disease name] commonly affects [age group].
| |
|
| |
| ===Race===
| |
|
| |
| *There is no racial predilection to [disease name].
| |
| *[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
| |
|
| |
| ===Gender===
| |
|
| |
| *[Disease name] affects men and women equally.
| |
| *[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.
| |
|
| |
| ===Region===
| |
|
| |
| *The majority of [disease name] cases are reported in [geographical region].
| |
|
| |
| *[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
| |
|
| |
| ===Developed Countries===
| |
|
| |
| ===Developing Countries===
| |
|
| |
| ==References==
| |
|
| |
|
| ==[[Autoimmune lymphoproliferative syndrome risk factors|Risk Factors]]== | | ==[[Autoimmune lymphoproliferative syndrome risk factors|Risk Factors]]== |
|
| |
| ==Overview==
| |
| There are no established risk factors for [disease name].
| |
|
| |
| OR
| |
|
| |
| The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
| |
|
| |
| OR
| |
|
| |
| Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
| |
|
| |
| OR
| |
|
| |
| Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
| |
|
| |
| ==Risk Factors==
| |
| There are no established risk factors for [disease name].
| |
|
| |
| OR
| |
|
| |
| The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
| |
|
| |
| OR
| |
|
| |
| Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
| |
|
| |
| ===Common Risk Factors===
| |
|
| |
| *Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
| |
| *Common risk factors in the development of [disease name] include:
| |
| **[Risk factor 1]
| |
| **[Risk factor 2]
| |
| **[Risk factor 3]
| |
|
| |
| ===Less Common Risk Factors===
| |
|
| |
| *Less common risk factors in the development of [disease name] include:
| |
| **[Risk factor 1]
| |
| **[Risk factor 2]
| |
| **[Risk factor 3]
| |
|
| |
| ==References==
| |
|
| |
|
| ==[[Autoimmune lymphoproliferative syndrome screening|Screening]]== | | ==[[Autoimmune lymphoproliferative syndrome screening|Screening]]== |
|
| |
| ==Overview==
| |
| There is insufficient evidence to recommend routine screening for [disease/malignancy].
| |
|
| |
| OR
| |
|
| |
| According to the [guideline name], screening for [disease name] is not recommended.
| |
|
| |
| OR
| |
|
| |
| According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].
| |
|
| |
| ==Screening==
| |
| There is insufficient evidence to recommend routine screening for [disease/malignancy].
| |
|
| |
| OR
| |
|
| |
| According to the [guideline name], screening for [disease name] is not recommended.
| |
|
| |
| OR
| |
|
| |
| According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with:
| |
|
| |
| *[Condition 1]
| |
| *[Condition 2]
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| *[Condition 3]
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| ==References==
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| ==[[Autoimmune lymphoproliferative syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]== | | ==[[Autoimmune lymphoproliferative syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
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| ==Overview==
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| If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
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| OR
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| Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
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| OR
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| Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
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| ==Natural History, Complications, and Prognosis==
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| ===Natural History===
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| *The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
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| *The symptoms of (disease name) typically develop ___ years after exposure to ___.
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| *If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
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| ===Complications===
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| *Common complications of [disease name] include:
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| **[Complication 1]
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| **[Complication 2]
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| **[Complication 3]
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| ===Prognosis===
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| *Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
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| *Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
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| *The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
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| *[Subtype of disease/malignancy] is associated with the most favorable prognosis.
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| *The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
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| ==References== | | ==References== |