Autoimmune lymphoproliferative syndrome physical examination: Difference between revisions

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Revision as of 14:03, 26 June 2021

Editor-In-Chief: David Teachey, MD [1]

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Common physical examination findings of Autoimmune lymphoproliferative syndrome(ALPS) include lymphadenopathy, Hepatomegaly, or splenomegaly. The majority of patients(80%) have enlarged, palpable, non -tender lymph nodes for an extended period of time. Cervical, axillary, inguinal lymphadenopathy are mostly found. But preauricular, submental, epitrochlear, mediastinal, and retroperitoneal nodes are detected occasionally. Moderate to massive splenomegaly is evident in 85% of patients with ALPS. Minor hepatomegaly is also a common finding. Lymphadenopathy, splenomegaly, hepatomegaly improve with age.

Lymphadenopathy: >90% of patients present with chronic non-malignant lymphadenopathy. It can be mild to severe, affecting multiple nodal groups. Most commonly presents with massive non-painful hard cervical lymphadenopathy

Splenomegaly: >80% of patients present with clinically identifiable splenomegaly. It can be massive.
Hepatomegaly: 30-40% of patients have enlarged livers.

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 ==Overview==
-Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].
-OR
+Common [[physical examination]] findings of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]) include [[lymphadenopathy]], [[Hepatomegaly]], or [[splenomegaly]]. The majority of [[patients]](80%) have enlarged, palpable, non -tender [[lymph nodes]] for an extended period of time. [[Cervical]], [[axillary]], [[inguinal]] [[lymphadenopathy]] are mostly found. But preauricular, submental, epitrochlear, mediastinal, and retroperitoneal nodes are detected occasionally. Moderate to massive [[splenomegaly]] is evident in 85% of [[patients]] with [[ALPS]]. Minor [[hepatomegaly]] is also a common finding. [[Lymphadenopathy]], [[splenomegaly]], [[hepatomegaly]] improve with age.
-Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].
-OR
-The presence of [finding(s)] on physical examination is diagnostic of [disease name].
-OR
-The presence of [finding(s)] on physical examination is highly suggestive of [disease name].
 ==Physical Examination==
 ===Skin===