Autoimmune lymphoproliferative syndrome other diagnostic studies: Difference between revisions
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{{Autoimmune lymphoproliferative syndrome}} | {{Autoimmune lymphoproliferative syndrome}} | ||
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==Overview== | ==Overview== | ||
The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | ||
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*Polyclonal [[plasmacytosis]] | *Polyclonal [[plasmacytosis]] | ||
*[[Spleen]] has expanded [[T cell]] areas dominated by [[DNT]] [[cells]]. | *[[Spleen]] has expanded [[T cell]] areas dominated by [[DNT]] [[cells]]. | ||
[[File:Gr3.jpg|center|thumb|Histopathology of spleen in ALPS.<ref name="LimStraus1998">{{cite journal|last1=Lim|first1=Megan S.|last2=Straus|first2=Stephen E.|last3=Dale|first3=Janet K.|last4=Fleisher|first4=Thomas A.|last5=Stetler-Stevenson|first5=Maryalice|last6=Strober|first6=Warren|last7=Sneller|first7=Michael C.|last8=Puck|first8=Jennifer M.|last9=Lenardo|first9=Michael J.|last10=Elenitoba-Johnson|first10=Kojo S.J.|last11=Lin|first11=Albert Y.|last12=Raffeld|first12=Mark|last13=Jaffe|first13=Elaine S.|title=Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome|journal=The American Journal of Pathology|volume=153|issue=5|year=1998|pages=1541–1550|issn=00029440|doi=10.1016/S0002-9440(10)65742-2}}</ref>]][[File:Gr1.jpg|center|thumb|Histopathology of lymph nodes in ALPS.<ref name="LimStraus1998" />]]<br /> | |||
==References== | ==References== | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The histopathologic study may be helpful in the diagnosis of Autoimmune lymphoproliferative syndrome(ALPS). Findings suggestive of ALPS include paracortical expansion due to infiltration of polyclonal TCR α/β+ DNT cells, follicular hyperplasia, and polyclonal plasmacytosis.
Other Diagnostic Studies
Histopathological study findings can be helpful to diagnose Autoimmune lymphoproliferative syndrome. The findings are
- Paracortical expansion with infiltration of polyclonal TCR α/β+ DNT cells.[1]
- DNT cells express TIA-1 and CD57, CD45RO negative
- Follicular hyperplasia
- Polyclonal plasmacytosis
- Spleen has expanded T cell areas dominated by DNT cells.
References
- ↑ Li, Pu; Huang, Ping; Yang, Ye; Hao, Mu; Peng, Hongwei; Li, Fei (2015). "Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)". Clinical Reviews in Allergy & Immunology. 50 (1): 55–63. doi:10.1007/s12016-015-8466-y. ISSN 1080-0549.
- ↑ 2.0 2.1 Lim, Megan S.; Straus, Stephen E.; Dale, Janet K.; Fleisher, Thomas A.; Stetler-Stevenson, Maryalice; Strober, Warren; Sneller, Michael C.; Puck, Jennifer M.; Lenardo, Michael J.; Elenitoba-Johnson, Kojo S.J.; Lin, Albert Y.; Raffeld, Mark; Jaffe, Elaine S. (1998). "Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome". The American Journal of Pathology. 153 (5): 1541–1550. doi:10.1016/S0002-9440(10)65742-2. ISSN 0002-9440.