|
|
| Line 1: |
Line 1: |
| {{AE}} Henry A. Hoff
| | #REDIRECT [[Forkhead box gene transcriptions]] |
| | |
| "Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes."<ref name=Myatt>{{ cite journal
| |
| |author=Stephen S. Myatt & Eric W. -F. Lam
| |
| |title=The emerging roles of forkhead box (Fox) proteins in cancer
| |
| |journal=Nature Reviews Cancer
| |
| |month=November
| |
| |year=2007
| |
| |volume=7
| |
| |issue=
| |
| |pages=847-859
| |
| |url=http://www.nature.com/nrc/journal/v7/n11/abs/nrc2223.html
| |
| |arxiv=
| |
| |bibcode=
| |
| |doi=10.1038/nrc2223
| |
| |pmid=
| |
| |accessdate=2017-02-13 }}</ref>
| |
| | |
| "Forkhead box (FOX) proteins comprise a large family of transcription factors (TFs), members of which display functional diversity and participate in cellular processes ranging from development to immunity and metabolism<sup>1–2</sup>. More than 170 FOX family members have been identified from different species and classified into 19 subfamilies (from FOXA to FOXS)<sup>3–4</sup>."<ref name=Li/>
| |
| | |
| ==Deregulations==
| |
| | |
| The "deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer".<ref name=Myatt/>
| |
| | |
| ==Consensus sequences==
| |
| | |
| "FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. [We] report a 2.8 Å co-crystal structure of the FOXA2 DNA-binding domain (FOXA2-DBD) bound to a DNA duplex containing a forkhead consensus binding site (GTAAACA)."<ref name=Li>{{ cite journal
| |
| |author=Jun Li, Ana Carolina Dantas Machado, Ming Guo, Jared M. Sagendorf, Zhan Zhou, Longying Jiang, Xiaojuan Chen, Daichao Wu, Lingzhi Qu, Zhuchu Chen, Lin Chen, Remo Rohs, and Yongheng Chen
| |
| |title=Structure of the forkhead domain of FOXA2 bound to a complete DNA consensus site
| |
| |journal=Biochemistry
| |
| |date=25 July 2017
| |
| |volume=56
| |
| |issue=29
| |
| |pages=3745-3753
| |
| |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614898/
| |
| |arxiv=
| |
| |bibcode=
| |
| |doi=10.1021/acs.biochem.7b00211
| |
| |pmid=28644006
| |
| |accessdate=28 August 2020 }}</ref>
| |
| | |
| "Most paralogous FOX proteins bind to the canonical DNA response element 5′-RYAAAYA-3′ (R = A or G, Y = C or T)<sup>11–13</sup>."<ref name=Li/>
| |
| | |
| "Genome-wide analysis of FOXA2-binding sites by ChIP-seq in human and mouse adult liver tissues suggested that FOXA2 binds to the consensus sequence (5′-GTAAACA-3′) of the FOX family<sup>24–25</sup>."<ref name=Li/>
| |
| | |
| ==Acknowledgements==
| |
| | |
| The content on this page was first contributed by: Henry A. Hoff.
| |
| | |
| Initial content for this page in some instances came from [http://www.wikiversity.org Wikiversity].
| |
| | |
| ==See also==
| |
| {{div col|colwidth=20em}}
| |
| * [[Complex locus A1BG and ZNF497]]
| |
| {{Div col end}}
| |
| | |
| ==References==
| |
| {{reflist|2}}
| |
| | |
| ==External links==
| |
| | |
| <!-- footer templates -->
| |
| {{Gene project}}{{Sisterlinks|Forkhead boxes}}
| |
| | |
| <!-- footer categories -->
| |
| [[Category:Gene project/Lectures]]
| |
| [[Category:Resources last modified in August 2020]]
| |