Autoimmune lymphoproliferative syndrome other diagnostic studies: Difference between revisions
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{{Autoimmune lymphoproliferative syndrome}} | {{Autoimmune lymphoproliferative syndrome}} | ||
{{CMG}} | {{CMG}} {{AE}}{{SharmiB}} | ||
==Overview== | ==Overview== | ||
The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | ||
Revision as of 04:14, 3 August 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S
Overview
The histopathologic study may be helpful in the diagnosis of Autoimmune lymphoproliferative syndrome(ALPS). Findings suggestive of ALPS include paracortical expansion due to infiltration of polyclonal TCR α/β+ DNT cells, follicular hyperplasia, and polyclonal plasmacytosis.
Other Diagnostic Studies
Histopathological study findings can be helpful to diagnose Autoimmune lymphoproliferative syndrome. The findings are
- Paracortical expansion with infiltration of polyclonal TCR α/β+ DNT cells.[1]
- DNT cells express TIA-1 and CD57, CD45RO negative
- Follicular hyperplasia
- Polyclonal plasmacytosis
- Spleen has expanded T cell areas dominated by DNT cells.
References
- ↑ Li, Pu; Huang, Ping; Yang, Ye; Hao, Mu; Peng, Hongwei; Li, Fei (2015). "Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)". Clinical Reviews in Allergy & Immunology. 50 (1): 55–63. doi:10.1007/s12016-015-8466-y. ISSN 1080-0549.
- ↑ 2.0 2.1 Lim, Megan S.; Straus, Stephen E.; Dale, Janet K.; Fleisher, Thomas A.; Stetler-Stevenson, Maryalice; Strober, Warren; Sneller, Michael C.; Puck, Jennifer M.; Lenardo, Michael J.; Elenitoba-Johnson, Kojo S.J.; Lin, Albert Y.; Raffeld, Mark; Jaffe, Elaine S. (1998). "Pathological Findings in Human Autoimmune Lymphoproliferative Syndrome". The American Journal of Pathology. 153 (5): 1541–1550. doi:10.1016/S0002-9440(10)65742-2. ISSN 0002-9440.