|
|
Line 3: |
Line 3: |
| * [[Neurogenic]] | | * [[Neurogenic]] |
| * [[Vasovagal syncope|vasovagal]] | | * [[Vasovagal syncope|vasovagal]] |
|
| |
| The DSM 5 is:<ref>"NUmber1"{{cite book | last = LastName | first = FirstName | title = Diagnostic and statistical manual of mental disorders : DSM-5 | publisher = American Psychiatric Association,American Psychiatric Association | location = Arlington, VA Washington, D.C | year = 2013 | isbn = 978-0-89042-554-1 }}</ref>
| |
|
| |
| <ref>......</ref>
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|
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|
| |
| *[[File:xyz|200px|center|thumb|case courtesy of radiopedia]]
| |
| *
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|
| |
| {| class="wikitable"
| |
| |+
| |
| ! style="padding: 5px 5px; background: #FFFFE0; " align="center" |Aorta
| |
| | style="padding: 5px 5px; background: #90EE90;" align="center" |Syncope
| |
| !
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| !
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| |-
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| |}
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| {{familytree/start}}
| |
| {{familytree | | | | | | | | | A01 | | | | | |A01=Syncope}}
| |
| {{familytree | | | | | | | | | |!| | | | | | | | }}
| |
| {{familytree | | | | | | | | | B01 | | | | | |B01=Classified to}}
| |
| {{familytree | | |,|-|-|-|-|-|-|+|-|-|-|-|-|-|.| }}
| |
| {{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Cardiac|C02=neurogenci|C03=vasovagal}}
| |
| {{familytree | | | | | | | | | |!| | | | | | | | }}
| |
| {{familytree | |,|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|.| | }}
| |
| {{familytree | |!| | | |!| | | |!| | | |!| | | |!| | | }}
| |
| {{familytree | D01 | | D02 | | D03 | | D04 | | D05 |D01=D01|D02=D02|D03=D03|D04=D04|D05=D05}}
| |
| {{familytree | |!| | | | | | | | | | | | | | | |!| }}
| |
| {{familytree | E01 | | | | | | | | | | | | | | E02 |E01=E01|E02=E02}}
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| {{familytree/end}}
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| [[File:Annular-pancreas.jpg|center|500px|thumb|Case courtesy of Dr Morlie L Wang, Radiopaedia.org, rID: 13924]]
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|
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|
| |
| ==Syncope==
| |
|
| |
| ===Syncope Definition===
| |
| [[Syncope]] is classified to three types:
| |
|
| |
|
| |
| *[[Cardiac]]
| |
| *[[Neurogenic]]
| |
| *[[Vasovagal syncope|Vasovagal]]
| |
|
| |
| <br />
| |
| {| class="wikitable"
| |
| |+
| |
| ! colspan="5" |DDX of syncope
| |
| |-
| |
| |'''Condition'''
| |
| |History
| |
| |Physical
| |
| |Lab finfings
| |
| |
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| |-
| |
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| |-
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| |-
| |
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| |}
| |
|
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|
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|
| |
| <br />{{familytree/start |summary=Sample 1}}
| |
| {{familytree | | | | | | | | A01 |A01=Syncope}}
| |
| {{familytree | | | | |,|-|-|-|^|-|-|-|-|.| | | }}
| |
| {{familytree | | | B01 | | | | | | | | B02 | | |B01=cardiac|B02=neurogenic}}
| |
| {{familytree | | | |!| | | | | | | | | |!| }}
| |
| {{familytree | | | C01 | | | | | | | | |!| |C01=C01}}
| |
| {{familytree | |,|-|^|.| | | | | | | | |!| }}
| |
| {{familytree | D01 | | D02 | | | | | | D03 |D01=D01|D02=D02|D03=D03}}
| |
| {{familytree | |!| | | | | | | | | |,|-|^|.| }}
| |
| {{familytree | E01 | | | | | | | E02 | | | E03 |E01=E01|E02=E02|E03=E03}}
| |
| {{familytree | | | | | | | | | | |!| | | | |!| }}
| |
| {{familytree | | | | | | | | | | F01 | | | F02 |F01=F01|F02=F02}}
| |
| {{familytree/end}}
| |
|
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|
| |
| [[File:Apple-core-sign-of-colonic-cancer-1.jpg|center|200px|thumb|Case courtesy of Dr Mohamed Mahmoud Elthokapy, Radiopaedia.org, rID: 91033]]
| |
|
| |
|
| |
|
| |
|
| |
| Aortic dissection is a life-threating disorder.
| |
|
| |
|
| |
| ==Differential Diagnosis of Aortic Dissection==
| |
| ===Differential Diagnosis of Aortic Dissection===
| |
| The ddx includes:
| |
| {| class="wikitable"
| |
| |+
| |
| ! colspan="4" |Aortic dissection DDX
| |
| |-
| |
| !Disease
| |
| !Histrory
| |
| !Physical exam findings
| |
| !
| |
| |-
| |
| !
| |
| !
| |
| !
| |
| !
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |}
| |
| <br />
| |
| ==overview==
| |
|
| |
|
| |
| Syncope is classified into three types:
| |
|
| |
| *Cardiac
| |
| *Vasovagal
| |
| *Neurogenic
| |
|
| |
|
| |
| {| class="wikitable"
| |
| ! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Differentiating diagnosis of Lymphoma
| |
| ! colspan="5" style="background:#4479BA; color: #FFFFFF;" align="center" + |Symptoms
| |
| ! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" + |Signs
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Diagnosis
| |
| ! rowspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Additional Findings
| |
| |-
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Fever
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Rash
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Diarrhea
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Abdominal pain
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Weight loss
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Painful lymphadenopathy
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Hepatosplenomegaly
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Arthritis
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Lab Findings
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Autoimmune lymphoproliferative syndrome
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Lymphoma]]
| |
| | +
| |
| |–
| |
| |–
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| |–
| |
| |Increase [[ESR]], increased [[LDH]]
| |
| |[[Night sweats]], constant fatigue
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Brucellosis]]
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| | +
| |
| | +
| |
| | +
| |
| | +
| |
| |[[Lymphocytosis|Relative lymphocytosis]]
| |
| |[[Night sweats]], often with characteristic smell, likened to wet hay
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Typhoid fever]]
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| |–
| |
| |–
| |
| | +
| |
| | +
| |
| |Decreased [[hemoglobin]]
| |
| |Incremental increase in temperature initially and than sustained [[fever]] as high as 40°C (104°F)
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Malaria]]
| |
| | +
| |
| |–
| |
| | +
| |
| | +
| |
| |–
| |
| |–
| |
| | +
| |
| | +
| |
| |Microcytosis,
| |
| elevated [[LDH]]
| |
| |"Tertian" fever: paroxysms occur every second day
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Tuberculosis]]
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| |Mild normocytic [[anemia]], [[hyponatremia]], and
| |
| [[hypercalcemia]]
| |
| |[[Night sweats]], constant fatigue
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Mumps]]
| |
| | +
| |
| |–
| |
| |–
| |
| |–
| |
| |–
| |
| | +
| |
| |–
| |
| |–
| |
| |[[Lymphocytosis|Relative lymphocytosis]], serum [[amylase]]<nowiki/>elevated
| |
| |[[Parotid gland|Parotid]]<nowiki/>swelling/tenderness
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Rheumatoid arthritis]]
| |
| |–
| |
| | +
| |
| |–
| |
| |–
| |
| |–
| |
| |–
| |
| |–
| |
| | +
| |
| |[[ESR]] and [[CRP]] elevated, positive [[rheumatoid factor]]
| |
| |Morning stiffness
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[SLE]]
| |
| |–
| |
| | +
| |
| |–
| |
| | +
| |
| | +
| |
| |–
| |
| |–
| |
| | +
| |
| |[[ESR]] and [[CRP]] elevated, positive [[ANA]]
| |
| |[[Fatigue]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Human Immunodeficiency Virus|HIV]]
| |
| |–
| |
| |–
| |
| |–
| |
| | +
| |
| | +
| |
| | +
| |
| |–
| |
| | +
| |
| |Leukopenia
| |
| |Constant fatigue
| |
| |}
| |
|
| |
| CNS lymphoma must be differentiated from other causes of seizures, headache, and fever in immunocompromised patients such as disseminated tuberculosis and disseminated aspergillosis.
| |
| {| class="wikitable"
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Disease
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Differentiating signs and symptoms
| |
| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Differentiating tests
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |Autoimmune lymphoproliferative syndrome
| |
| |
| |
| |
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Lymphoma|CNS lymphoma]]
| |
| |
| |
| *Patient is [[immunocompetent]]
| |
| *Focal symptoms indicative of a mass [[lesion]]
| |
| *[[Seizure]]
| |
| |
| |
| *Single solitary ring enhancing [[lesion]] on [[CT]] or [[MRI]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Disseminated tuberculosis]]
| |
| |
| |
| *Prior history of residence in an [[Endemic (epidemiology)|endemic]] area
| |
| *Chronic [[cough]], [[weight loss]], [[hemoptysis]]
| |
| |
| |
| *[[PCR]] of [[CSF]] for [[tuberculosis]]
| |
| *Mycobacterial culture of [[CSF]]
| |
| *[[Brain]] biopsy for [[acid-fast bacilli]] staining
| |
| *Culture and acid stain positive for [[acid-fast bacilli]]
| |
| *CXR shows [[Cavitation|cavitations]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Aspergillosis]]
| |
| |
| |
| *[[Pulmonary]] [[lesions]] in addition to [[CNS]] [[lesions]]
| |
| *Symptoms may include [[cough]], [[chest pain]], and [[hemoptysis]]
| |
| |
| |
| *[[CSF]] fungal culture, [[galactomannan]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Cryptococcosis]]
| |
| |
| |
| *Symptoms include [[cough]], [[chest pain]], and [[hemoptysis]]
| |
| |
| |
| *[[Cryptococcal infection|Cryptococcal]] [[antigen]] from [[CSF]] and [[serum]]
| |
| *[[CSF]] fungal culture
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Chagas disease]]
| |
| |
| |
| *History of residence in Central or South America
| |
| *Acute infection is rarely symptomatic
| |
| *[[Encephalitis]] or focal [[brain]] [[lesions]]
| |
| *[[Myocarditis]]
| |
| *[[Chronic]] [[infections]] in [[immunocompromised]] patients develop into [[encephalitis]] with [[necrotic]] [[brain]] lesions causing a [[mass effect]]
| |
| |
| |
| *[[Trypanosoma cruzi]] in [[blood]], [[Tissue (biology)|tissue]], or [[CSF]], [[PCR]] of [[Tissue (biology)|tissue]] or [[body fluids]], and [[Serological testing|serologic tests]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Cytomegalovirus infection|CMV infection]]
| |
| |
| |
| *Most common [[CNS]] [[opportunistic infection]] in [[AIDS]] patients
| |
| *Presents with [[encephalitis]], [[retinitis]], progressive [[myelitis]], or [[polyradiculitis]]
| |
| *In [[disseminated disease]], it involves both the [[liver]] and kidneys
| |
| |
| |
| *[[Brain]] [[CT]]/[[MRI]]/[[biopsy]]: location of [[lesions]] is usually near the [[brain stem]] or periventricular areas
| |
| *[[PCR]] of [[CSF]] with detectable [[virus]] is diagnostic
| |
| *[[Brain biopsy]] with + [[staining]] for [[CMV]] or evidence of owl's eyes is also diagnostic, but it is rarely performed because of the location of [[brain]] lesions
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[HSV|HSV infection]]
| |
| |
| |
| *[[Seizures]], [[headache]], [[confusion]] and/or [[urinary retention]] can be seen in [[disseminated disease]], which usually affects only the [[immunocompromised]] or acute [[infections]]
| |
| *In [[pregnant]] women, it may be associated with concurrent [[genital]]/[[oral]] [[lesions]]; can be spread to the [[neonate]] during acute infection in the mother, or via [[viral shedding]] in the [[birth canal]]
| |
| *[[Neonatal]] [[Herpes simplex virus|HSV]] can range from localized [[Skin and soft-tissue infections|skin infections]] to [[encephalitis]], [[pneumonitis]], and [[disseminated disease]]
| |
| |
| |
| *[[Brain]] [[CT]]/[[MRI]]/[[biopsy]]: location of [[lesions]] is usually the [[medial]] [[temporal lobe]] or the [[Orbital cavity|orbital]] surface of the [[frontal lobe]].
| |
| *[[PCR]] of [[CSF]] with detectable [[virus]] is diagnostic
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Chickenpox|Varicella Zoster infection]]
| |
| |
| |
| *Multifocal involvement has subacute course, usually only in [[immunosuppressed]], with [[headache]], [[fever]], focal deficits, and [[seizures]].
| |
| *Unifocal involvement is more typically seen in [[immunocompetent]] hosts, occurring after [[contralateral]] [[cranial nerve]] [[herpes zoster]], with [[Altered mental status|mental status changes]], [[TIA|TIAs]], and [[stroke]]
| |
| *[[Disseminated disease|Disseminated]] [[varicella zoster virus]] can occur in adults during primary [[infection]], presenting with [[pneumonitis]] and/or [[hepatitis]]
| |
| *Disease is a [[Vasculitis|vasculopathy]] with [[hemorrhage]] and [[stroke]]
| |
| |
| |
| *[[PCR]] of [[CSF]] with detectable [[virus]] is diagnostic
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Brain abscess]]
| |
| |
| |
| *Associated with [[sinusitis]] (abutting the sinuses) or with [[bacteremia]]
| |
| *Signs and symptoms includes [[fever]] and [[necrotizing]] [[brain]] [[lesions]] with [[mass effect]]
| |
| |
| |
| *[[CSF]] culture or culture of [[brain abscess]]
| |
| |-
| |
| | style="background:#DCDCDC;" align="center" + |[[Progressive multifocal leukoencephalopathy]]
| |
| |
| |
| *Symptoms are often more insidious in onset and progress over months. Symptoms include progressive [[weakness]], poor [[coordination]], with gradual slowing of [[mental]] function. Only seen in the [[immunosuppressed]]. Rarely associated with [[fever]] or other systemic symptoms
| |
|
| |
| |
| |
| *[[Polymerase chain reaction|PCR]] of [[CSF]] for [[JC virus]]
| |
| *[[Biopsy]] reveals [[white matter]] [[lesions]] and not well-circumscribed [[lesions]].
| |
| |}
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
| [[File:Bilateral-hip-avascular-necrosis-6.jpg|center|300px|thumb|Case courtesy of Dr Bahman Rasuli, Radiopaedia.org, rID: 90579]]
| |
| ==Classification==
| |
| [[Syncope]] is classified into three components:
| |
|
| |
| *[[Cardiac]]
| |
| **[[Neurogenic]]
| |
| *[[Vasovagal syncope|Vasovagal]]
| |
|
| |
| <br />
| |
| {| class="wikitable"
| |
| |+
| |
| ! colspan="4" |Classification of Syncope
| |
| |-
| |
| |'''Type'''
| |
| |Pathophysiology
| |
| |Treatment
| |
| |Additional information
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |}
| |
|
| |
|
| |
|
| |
|
| |
|
| |
| <br />{{familytree/start |summary=Sample 1}}
| |
| {{familytree | | | | | | | | A01 |A01=syncope}}
| |
| {{familytree | | | | |,|-|-|-|^|-|-|-|-|.| | | }}
| |
| {{familytree | | | B01 | | | | | | | | B02 | | |B01=cardiac|B02=neurogenic}}
| |
| {{familytree | | | |!| | | | | | | | | |!| }}
| |
| {{familytree | | | C01 | | | | | | | | |!| |C01=C01}}
| |
| {{familytree | |,|-|^|.| | | | | | | | |!| }}
| |
| {{familytree | D01 | | D02 | | | | | | D03 |D01=D01|D02=D02|D03=D03}}
| |
| {{familytree | |!| | | | | | | | | |,|-|^|.| }}
| |
| {{familytree | E01 | | | | | | | E02 | | | E03 |E01=E01|E02=E02|E03=E03}}
| |
| {{familytree | | | | | | | | | | |!| | | | |!| }}
| |
| {{familytree | | | | | | | | | | F01 | | | F02 |F01=F01|F02=F02}}
| |
| {{familytree/end}}
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
| [[File:Fl000816-300x300.jpg|center|200px|thumb|wikimedia commons|link=Special:FilePath/Fl000816-300x300.jpg]]
| |
|
| |
|
| |
| {| class="wikitable"
| |
| |+
| |
| !disease
| |
| ! colspan="4" |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |}
| |
|
| |
|
| |
|
| |
|
| |
| Syncope is classified into three types.
| |
|
| |
|
| |
| [[File:Sheehan.jpg|center|200px|thumb|Wikimedia commons]]
| |
|
| |
|
| |
|
| |
|
| |
| {| class="wikitable"
| |
| |+
| |
| ! colspan="4" |Syncope classification
| |
| |-
| |
| |Cardia
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |-
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |}
| |
|
| |
| ==Syncope==
| |
|
| |
| ==Syncope is classified to three types:==
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| [[Syncope]] is classified into three types:
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| __NOTOC__
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| {{CMG}} {{AE}} {{Sahar}}
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| {{familytree/start}}<nowiki>{{familytree | | | | | | | | | A01 | | | | | |A01=Syncope}}
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| {{familytree | | | | | | | | | |!| | | | | | | | }}
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| {{familytree | | | | | | | | | B01 | | | | | |B01=B01}}
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| {{familytree | | |,|-|-|-|-|-|-|+|-|-|-|-|-|-|.| }}
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| {{familytree | | C01 | | | | | C03 | | | | |C02|C01=C01|C02=C02|C03=C03}}
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| {{familytree | | |!| | | | | | | | | | | | | |!| }}
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| {{familytree | | D01 | | | | | | | | | | | |D02|D01=D01'<br>D01''|D02=D02'<br>D02''}}
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| {{familytree | | |!| | | | | | | | | |,|-|-|-|+|-|-|-|-|.|}}
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| {{familytree | | E01 | | | | | | | | E02 | | E03 | | | E04 |E01=E01|E02=E02|E03=E03|E04=E04}}
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| {{familytree | | | | | | | | | | | | |!| | | |!| | | | |!| | }}
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| {{familytree | | | | | | | | | | | | F01 | | F02 | | | F03 |F01=F01|F02=F02|F03=F03}}
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| {{familytree/end}}
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| [[File:1196px-Rtbl400.gif|200px|center|Source:Wikimedia commons]]
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| ==Syncope classifications:==
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| *Orthostatic:
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| *Cardiac
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| *Neurolgoic
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| <br />
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| {| class="wikitable"
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| ! colspan="5" |Syncope ddx
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| |-
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| |Clinical manifestations
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| |-
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| |-
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| |-
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| |}
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| <br />
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| <references />
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