Angiodysplasia pathophysiology: Difference between revisions
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==Histology== | ==Histology== | ||
Angiodysplastic lesions on histology appear as ectatic, thin-walled blood vessels in mucosa or submucosa. | Angiodysplastic lesions on histology appear as ectatic, thin-walled blood vessels in mucosa or submucosa.<ref name="pmid1544666">{{cite journal| author=Thelmo WL, Vetrano JA, Wibowo A, DiMaio TM, Cruz-Vetrano WP, Kim DS| title=Angiodysplasia of colon revisited: pathologic demonstration without the use of intravascular injection technique. | journal=Hum Pathol | year= 1992 | volume= 23 | issue= 1 | pages= 37-40 | pmid=1544666 | doi=10.1016/0046-8177(92)90008-q | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1544666 }} </ref> | ||
==References== | ==References== | ||
Revision as of 01:13, 11 September 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pathophysiology
- The exact pathogenesis of angiodysplasia is still unknown.
- According to a theory, angiodysplasia develops due to chronic obstruction of submucosal veins coupled with the effect of ageing, ultimately leading to the formation of small arterio-venous collaterals.[1]
- Some studies have revealed increased levels of angiogenic factors like vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang1), Ang2 etc. in small bowel and human colonic angiodysplasia.[2][3]
- It has also been proposed that aortic stenosis, von Willebrand disease and chronic renal failure by various mechanisms contribute to development of angiodysplasia.[1]
Histology
Angiodysplastic lesions on histology appear as ectatic, thin-walled blood vessels in mucosa or submucosa.[4]
References
- ↑ 1.0 1.1 Sami SS, Al-Araji SA, Ragunath K (2014). "Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management". Aliment Pharmacol Ther. 39 (1): 15–34. doi:10.1111/apt.12527. PMID 24138285.
- ↑ Holleran G, Hussey M, Smith S, McNamara D (2017). "Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia". World J Gastrointest Pathophysiol. 8 (3): 127–132. doi:10.4291/wjgp.v8.i3.127. PMC 5561433. PMID 28868182.
- ↑ Holleran G, Hall B, O'Regan M, Smith S, McNamara D (2015). "Expression of Angiogenic Factors in Patients With Sporadic Small Bowel Angiodysplasia". J Clin Gastroenterol. 49 (10): 831–6. doi:10.1097/MCG.0000000000000260. PMID 25319741.
- ↑ Thelmo WL, Vetrano JA, Wibowo A, DiMaio TM, Cruz-Vetrano WP, Kim DS (1992). "Angiodysplasia of colon revisited: pathologic demonstration without the use of intravascular injection technique". Hum Pathol. 23 (1): 37–40. doi:10.1016/0046-8177(92)90008-q. PMID 1544666.