Angiodysplasia differential diagnosis: Difference between revisions
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| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Colon cancer</small> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Colon cancer</small> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | +/- | | style="background: #F5F5F5; padding: 5px; text-align: center;" | +/- | ||
| style="background: #F5F5F5; padding: 5px;" | +/- | | style="background: #F5F5F5; padding: 5px;" text-align: center; | +/- | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Weight loss</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Weight loss</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Lmyphadenopathies</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Lmyphadenopathies</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Abdominal mass</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Abdominal mass</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Hepatomegaly (metastasis)</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Hepatomegaly (metastasis)</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Tumor marker - CEA</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Tumor marker - CEA</small> | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" |<small>CT with contrast chest, abdomen and pelvis</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>CT with contrast chest, abdomen and pelvis</small> | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Majority of colorectal cancers are carcinomas.</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Majority of colorectal cancers are carcinomas.</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Colonoscopy</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Colonoscopy</small> | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Massive upper GI bleed</small> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Massive upper GI bleed</small> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | + | | style="background: #F5F5F5; padding: 5px; text-align: center;" | + | ||
| style="background: #F5F5F5; padding: 5px;" | + | | style="background: #F5F5F5; padding: 5px;" text-align: center; | + | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Melena</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Melena</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Hemodynamic instability</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Hemodynamic instability</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Upper abdominal tenderness</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Upper abdominal tenderness</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Pale skin</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Pale skin</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Acute bleeding - normocytic anemia</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Acute bleeding - normocytic anemia</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Elevated BUN-to-Creatinine ratio >30:1</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Elevated BUN-to-Creatinine ratio >30:1</small> | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" |<small>CT angiography</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>CT angiography</small> | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" text-align: center; | | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Endoscopy</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Endoscopy</small> | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Inflammatory bowel disease</small> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |<small>Inflammatory bowel disease</small> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | + | | style="background: #F5F5F5; padding: 5px; text-align: center;" | + | ||
| style="background: #F5F5F5; padding: 5px;" |<small>+/-</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>+/-</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Abdominal pain</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Abdominal pain</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Tachycardia, fever,</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Tachycardia, fever,</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Occult blood on digital rectal exam</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Occult blood on digital rectal exam</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Anal fistulas, abscesses</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Anal fistulas, abscesses</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Microcytic anemia</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Microcytic anemia</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Leukocytosis</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Leukocytosis</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Elevated ESR, CRP</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Elevated ESR, CRP</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Abdominal X ray - free air, bowel obstruction, toxic megacolon</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Abdominal X ray - free air, bowel obstruction, toxic megacolon</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Barium studies</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Barium studies</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Ultrasound/CT/MRI</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>Ultrasound/CT/MRI</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>UC- crypt abscess</small> | | style="background: #F5F5F5; padding: 5px;" text-align: center; |<small>UC- crypt abscess</small> | ||
<small>Crohn's- transmural involvement, granulomas</small> | <small>Crohn's- transmural involvement, granulomas</small> | ||
| style="background: #F5F5F5; padding: 5px;" |<small>Endoscopy</small> | | style="background: #F5F5F5; padding: 5px;" |<small>Endoscopy</small> |
Revision as of 15:10, 11 September 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nikita Singh, M.D.[2]
Overview
Angiodysplasia must be differentiated from other diseases that cause hematochezia, melena, and iron deficiency anemia, such as hemorrhoids, diverticular disease, and colon cancer.
Differentiating Angiodysplasia from other Diseases
Angiodysplasia must be differentiated from from other diseases that cause hematochezia, melena, and iron deficiency anemia such as:
Diseases | Clinical manifestations | Para-clinical findings | Gold standard | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examination | |||||||||||||
Lab Findings | Imaging | Histopathology | ||||||||||||
Abdominal pain | Lower GI Bleed | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | |||
Diverticulitis | + | + | Diarrhoea | Left lower quadrant abdominal tenderness | Bowel sounds hypoactive/normoactive | Fever | Leukocytosis | Elevated ESR and CRP | Radiological test of choice - CT of abdomen and pelvis with contrast | Abdominal Ultrasound | MRI abdomen | Colonoscopy after resolution of inflammation | ||
Hemorrhoids | - (anal pain) | + | Anal protrusion | Skin tags | Fistulas or fissures | Prolapsed hemorrhoid | External hemorrhoids - distal to dentate line.
Internal hemorrhoids - proximal to dentate line. |
Anoscopy | ||||||
Colon cancer | +/- | +/- | Weight loss | Lmyphadenopathies | Abdominal mass | Hepatomegaly (metastasis) | Tumor marker - CEA | CT with contrast chest, abdomen and pelvis | Majority of colorectal cancers are carcinomas. | Colonoscopy | ||||
Massive upper GI bleed | + | + | Melena | Hemodynamic instability | Upper abdominal tenderness | Pale skin | Acute bleeding - normocytic anemia | Elevated BUN-to-Creatinine ratio >30:1 | CT angiography | Endoscopy | ||||
Inflammatory bowel disease | + | +/- | Abdominal pain | Tachycardia, fever, | Occult blood on digital rectal exam | Anal fistulas, abscesses | Microcytic anemia | Leukocytosis | Elevated ESR, CRP | Abdominal X ray - free air, bowel obstruction, toxic megacolon | Barium studies | Ultrasound/CT/MRI | UC- crypt abscess
Crohn's- transmural involvement, granulomas |
Endoscopy |
Angiodysplasia | - | + (occult) | No abdominal pain | Signs of anemia | Systolic ejection murmur (if aortic stenosis) | Rarely, orthostasis or hypotension | Microcytic anemia | Renal and liver function tests | Coagulation studies | Radionuclide scanning | CTA/MRA | Upper GI endoscopy and colonoscopy | Tortuous, dilated veins, venules and capillaries in the colonic mucosa and submucosa | Endoscopy |