Cavernous angioma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Clinical symptoms of this disease include recurrent [[headache]]s, focal neurological deficits, hemorrhagic [[stroke]] | |||
* Clinical symptoms of this disease include: | |||
** recurrent [[headache]]s, | |||
** focal neurological deficits, | |||
** hemorrhagic [[stroke]] | |||
** [[seizures]] | |||
* CCM can also be [[asymptomatic]]. Familial forms can present asymptomatically, however, when it becomes symptomatic, seizure is the most common symptom. <ref name="pmid30909834">{{cite journal| author=Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL | display-authors=etal| title=Familial Cerebral Cavernous Malformations. | journal=Stroke | year= 2019 | volume= 50 | issue= 5 | pages= 1294-1301 | pmid=30909834 | doi=10.1161/STROKEAHA.118.022314 | pmc=6924279 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30909834 }} </ref> | |||
==History and Symptoms== | ==History and Symptoms== | ||
This disease is characterized by grossly dilated blood vessels with a single layer of [[endothelium]] and an absence of neuronal tissue within the lesions. These thinly-walled vessels resemble sinusoidal cavities filled with stagnant blood. Blood vessels in patients with CCM can range from a few millimeters to several centimeters in diameter. CCM lesions commonly resemble raspberries in external structure. | * This disease is characterized by grossly dilated blood vessels with a single layer of [[endothelium]] and an absence of neuronal tissue within the lesions. | ||
* These thinly-walled vessels resemble sinusoidal cavities filled with stagnant blood. | |||
* Blood vessels in patients with CCM can range from a few millimeters to several centimeters in diameter. CCM lesions commonly resemble raspberries in external structure. | |||
* Many patients live their whole life without knowing they have a cerebral cavernous malformation. | |||
* Other patients can have severe symptoms like seizures, headaches, paralysis, bleeding in the brain ([[cerebral hemorrhage]], or [[hemorrhagic stroke]]), and even death. | |||
* The nature and severity of the symptoms depend on the lesion's location in the brain. Approximately 70% of these lesions occur in the [[supratentorial]] region of the brain; the remaining 30% occur in the infratentorial region. | |||
==References== | ==References== | ||
Revision as of 07:54, 26 February 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
- Clinical symptoms of this disease include:
- CCM can also be asymptomatic. Familial forms can present asymptomatically, however, when it becomes symptomatic, seizure is the most common symptom. [1]
History and Symptoms
- This disease is characterized by grossly dilated blood vessels with a single layer of endothelium and an absence of neuronal tissue within the lesions.
- These thinly-walled vessels resemble sinusoidal cavities filled with stagnant blood.
- Blood vessels in patients with CCM can range from a few millimeters to several centimeters in diameter. CCM lesions commonly resemble raspberries in external structure.
- Many patients live their whole life without knowing they have a cerebral cavernous malformation.
- Other patients can have severe symptoms like seizures, headaches, paralysis, bleeding in the brain (cerebral hemorrhage, or hemorrhagic stroke), and even death.
- The nature and severity of the symptoms depend on the lesion's location in the brain. Approximately 70% of these lesions occur in the supratentorial region of the brain; the remaining 30% occur in the infratentorial region.
References
- ↑ Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL; et al. (2019). "Familial Cerebral Cavernous Malformations". Stroke. 50 (5): 1294–1301. doi:10.1161/STROKEAHA.118.022314. PMC 6924279 Check
|pmc=value (help). PMID 30909834.