Cavernous angioma history and symptoms: Difference between revisions
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{{CMG}}; {{AE}}[[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]] | {{CMG}}; {{AE}}[[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]] | ||
==Overview== | ==Overview== | ||
Clinical symptoms of this disease include recurrent [[headache]]s, focal neurological deficits, hemorrhagic [[stroke]], and [[seizures]]. CCM can also be [[asymptomatic]]. Familial forms can present asymptomatically, however, when it becomes symptomatic, seizure is the most common symptom. <ref name="pmid30909834">{{cite journal| author=Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL | display-authors=etal| title=Familial Cerebral Cavernous Malformations. | journal=Stroke | year= 2019 | volume= 50 | issue= 5 | pages= 1294-1301 | pmid=30909834 | doi=10.1161/STROKEAHA.118.022314 | pmc=6924279 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30909834 }} </ref> | |||
==History and Symptoms== | ==History and Symptoms== | ||
Revision as of 21:09, 28 February 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Clinical symptoms of this disease include recurrent headaches, focal neurological deficits, hemorrhagic stroke, and seizures. CCM can also be asymptomatic. Familial forms can present asymptomatically, however, when it becomes symptomatic, seizure is the most common symptom. [1]
History and Symptoms
- This disease is characterized by grossly dilated blood vessels with a single layer of endothelium and an absence of neuronal tissue within the lesions.
- These thinly-walled vessels resemble sinusoidal cavities filled with stagnant blood.
- Blood vessels in patients with CCM can range from a few millimeters to several centimeters in diameter. CCM lesions commonly resemble raspberries in external structure.
- Many patients live their whole life without knowing they have a cerebral cavernous malformation.
- Other patients can have severe symptoms like seizures, headaches, paralysis, bleeding in the brain (cerebral hemorrhage, or hemorrhagic stroke), and even death.
- The nature and severity of the symptoms depend on the lesion's location in the brain. Approximately 70% of these lesions occur in the supratentorial region of the brain.
- The remaining 30% occur in the infratentorial region.
References
- ↑ Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL; et al. (2019). "Familial Cerebral Cavernous Malformations". Stroke. 50 (5): 1294–1301. doi:10.1161/STROKEAHA.118.022314. PMC 6924279 Check
|pmc=value (help). PMID 30909834.