Cavernous angioma natural history, complications and prognosis: Difference between revisions

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==Natural History==
==Natural History==
Once patients become symptomatic, 40-50% present with seizures, 20% present with [[focal neurologic deficits]], and 10-25% present with [[intracerebral parenchymal hemorrhage]].<ref name="pmid32524542">{{cite journal| author=Vercelli GG, Cofano F, Santonio FV, Vincitorio F, Zenga F, Garbossa D| title=Natural History, Clinical, and Surgical Management of Cavernous Malformations. | journal=Methods Mol Biol | year= 2020 | volume= 2152 | issue=  | pages= 35-46 | pmid=32524542 | doi=10.1007/978-1-0716-0640-7_3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32524542  }} </ref>
Once patients become [[symptomatic]], 40-50% present with [[seizures]], 20% present with [[focal neurologic deficits]], and 10-25% present with [[intracerebral parenchymal hemorrhage]].<ref name="pmid32524542">{{cite journal| author=Vercelli GG, Cofano F, Santonio FV, Vincitorio F, Zenga F, Garbossa D| title=Natural History, Clinical, and Surgical Management of Cavernous Malformations. | journal=Methods Mol Biol | year= 2020 | volume= 2152 | issue=  | pages= 35-46 | pmid=32524542 | doi=10.1007/978-1-0716-0640-7_3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32524542  }} </ref>


==Complications==
==Complications==

Revision as of 11:21, 11 March 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.


Overview

Cavernous angioma is usually a benign course since it is a low-flow and low-pressure lesion. Patients with cavernous angioma have variable signs and symptoms, with seizure as the most predominant symptom, followed by hemorrhage and focal neurologic deficit.

Natural History

Once patients become symptomatic, 40-50% present with seizures, 20% present with focal neurologic deficits, and 10-25% present with intracerebral parenchymal hemorrhage.[1]

Complications

Prognosis

  • The lesions do not usually produce life-threatening hemorrhages because most hemorrhages associated with the lesions are small and of low pressure. [1]
  • Cavernous malformations can occur at any age, but they are most likely to become clinically apparent in patients aged 20-40 years.

References

  1. 1.0 1.1 Vercelli GG, Cofano F, Santonio FV, Vincitorio F, Zenga F, Garbossa D (2020). "Natural History, Clinical, and Surgical Management of Cavernous Malformations". Methods Mol Biol. 2152: 35–46. doi:10.1007/978-1-0716-0640-7_3. PMID 32524542 Check |pmid= value (help).