Gangrene overview: Difference between revisions
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Gangrene is a complication of [[necrosis]] (i.e., [[Cell (biology)|cell]] death) characterized by the decay of [[biological tissue|body tissue]]s, which become black and malodorous. It is caused by [[infection]] or [[ischemia]], such as from [[thrombosis]] (blocked [[blood vessel]]). It is usually the result of critically insufficient [[blood]] supply (e.g., [[peripheral vascular disease]]) and is often associated with [[diabetes]] and long-term smoking. This condition is most common in the lower [[extremities]]. The best treatment for gangrene is [[revascularization]] (i.e., restoration of blood flow) of the affected organ, which can reverse some of the effects of necrosis and allow healing. Other treatments include [[debridement]] and surgical [[amputation]]. The method of treatment is generally determined depending on location of affected tissue and extent of tissue loss. Gangrene may appear as one effect of foot binding. | Gangrene is a complication of [[necrosis]] (i.e., [[Cell (biology)|cell]] death) characterized by the decay of [[biological tissue|body tissue]]s, which become black and malodorous. It is caused by [[infection]] or [[ischemia]], such as from [[thrombosis]] (blocked [[blood vessel]]). It is usually the result of critically insufficient [[blood]] supply (e.g., [[peripheral vascular disease]]) and is often associated with [[diabetes]] and long-term smoking. This condition is most common in the lower [[extremities]]. The best treatment for gangrene is [[revascularization]] (i.e., restoration of blood flow) of the affected organ, which can reverse some of the effects of necrosis and allow healing. Other treatments include [[debridement]] and surgical [[amputation]]. The method of treatment is generally determined depending on location of affected tissue and extent of tissue loss. Gangrene may appear as one effect of foot binding. | ||
==Historical Perspective== | ==Historical Perspective== | ||
==Classification== | ==Classification== | ||
==Causes== | ==Causes== | ||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
===Surgery=== | ===Surgery=== | ||
===Primary Prevention=== | ===Primary Prevention=== | ||
==References== | ==References== | ||
Revision as of 05:32, 24 March 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Gangrene is a complication of necrosis (i.e., cell death) characterized by the decay of body tissues, which become black and malodorous. It is caused by infection or ischemia, such as from thrombosis (blocked blood vessel). It is usually the result of critically insufficient blood supply (e.g., peripheral vascular disease) and is often associated with diabetes and long-term smoking. This condition is most common in the lower extremities. The best treatment for gangrene is revascularization (i.e., restoration of blood flow) of the affected organ, which can reverse some of the effects of necrosis and allow healing. Other treatments include debridement and surgical amputation. The method of treatment is generally determined depending on location of affected tissue and extent of tissue loss. Gangrene may appear as one effect of foot binding.