Galactosemia pathophysiology: Difference between revisions
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==='''Physiology'''=== | ==='''Physiology'''=== | ||
Galactose is metabolised in the body through the Leloir pathway. <ref name="pmid12923184">{{cite journal| author=Holden HM, Rayment I, Thoden JB| title=Structure and function of enzymes of the Leloir pathway for galactose metabolism. | journal=J Biol Chem | year= 2003 | volume= 278 | issue= 45 | pages= 43885-8 | pmid=12923184 | doi=10.1074/jbc.R300025200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12923184 }} </ref> | |||
* It begins with conversion of B-D-galactose to A-D-galactose | |||
*Ultimately, it results in the production of the metabolically more useful glucose-1-phosphate | |||
*Byproducts like UDP-galactose are easily interchangeable to UDP-glucose. | |||
(Image) | |||
==References== | ==References== | ||
Revision as of 14:49, 10 May 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dayana Davidis, M.D. [2]
Overview
Pathophysiology
- Galactose is an important metabolite of the human body both for neonatal and adult health, playing a vital role in systemic and cognitive development. [1]
Physiology
Galactose is metabolised in the body through the Leloir pathway. [2]
- It begins with conversion of B-D-galactose to A-D-galactose
- Ultimately, it results in the production of the metabolically more useful glucose-1-phosphate
- Byproducts like UDP-galactose are easily interchangeable to UDP-glucose.
(Image)
References
- ↑ Coelho AI, Berry GT, Rubio-Gozalbo ME (2015). "Galactose metabolism and health". Curr Opin Clin Nutr Metab Care. 18 (4): 422–7. doi:10.1097/MCO.0000000000000189. PMID 26001656.
- ↑ Holden HM, Rayment I, Thoden JB (2003). "Structure and function of enzymes of the Leloir pathway for galactose metabolism". J Biol Chem. 278 (45): 43885–8. doi:10.1074/jbc.R300025200. PMID 12923184.