Monkeypox history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Bassel Almarie, M.D.

History

The significant information in the patient's history include:

• Recent travel to endemic area
• Recent contact with person with similar complains or infected person with monkeypox

Any history of travel to the endemic areas Any ill contact with similar complaints

Diagnostic Criteria

Interim clinical, laboratory and epidemiologic criteria for case classification — U.S. Monkeypox Response, May 2022

Clinical and laboratory classification	Criteria
Suspected	New characteristic rash* OR
	Meets one of the epidemiologic criteria and has high clinical suspicion† for monkeypox
Probable	No suspicion of other recent orthopoxvirus exposure (e.g., Vaccinia virus in ACAM2000 vaccination) AND demonstration of the presence of
	•     Orthopoxvirus DNA by polymerase chain reaction testing of a clinical specimen OR
	•     Orthopoxvirus using immunohistochemical or electron microscopy testing methods OR
	•     Detectable levels of antiorthopoxvirus IgM antibody during the period of 4–56 days after rash onset
Confirmed	Demonstration of the presence of Monkeypox virus DNA by polymerase chain reaction testing or next-generation sequencing of a clinical specimen OR
	Isolation of Monkeypox virus in culture from a clinical specimen