Renal ectopia

Renal ectopia
ICD-10	Q63.2
ICD-9	753.3

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Renal ectopia or ectopic kidney describes a kidney that is not located in its usual position. It results from the kidney failing to ascend from its origin in the true pelvis or from a superiorly ascended kidney located in the thorax.

Crossed-fused renal ectopia

• Crossed ectopy = kidney located on the opposite side of the midline from its ureter.
• In 90% of crossed ectopy, there is at least partial fusion of the kidneys (the remainder demonstrate two discrete kidneys on the same side, crossed-unfused ectopy)
• Due to improper renal ascent in embryogenesis (4^th-8^th week of fetal life - normally, the kidney reaches its appropriate position at L2 level at the end of the 2^nd month)
• Fusion of the kidneys within the pelvis leads to crossed-fused renal ectopia.
• Abnormally situated umbilical artery prevents normal cephalic migration. Another theory is that the ureteric bud crosses to the opposite side and induces nephron formation in the contralateral metanephric blastema.

Epidemiology

• Incidence: 1 out of 1,000 births.
• 2:1 male to female ratio
• A single renal mass with two collecting systems is located on one side of the abdomen.
• Left-to-right ectopy three times more common.

Pathogenesis

• Normal ascent of the kidneys is required for formation of the extraperitoneal perirenal fascial planes.
• Ectopia (or renal agenesis) results in failure of development of fascial layers in the flanks on the side not occupied by renal tissue.
• Lack of restraining fascia leads to possible malposition of bowel into the extraperitoneal fat of the empty renal fossa and relaxation of mesenteric supports for bowel loops in this region.

Complications

• In a crossed fused renal ectopic kidney, complications such as nephrolithiasis, infection, and hydronephrosis approaches 50%.