Thallium

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iso	NA	half-life	DM	DE (MeV)	DP WikiDoc Resources for Thallium Articles Most recent articles on Thallium Most cited articles on Thallium Review articles on Thallium Articles on Thallium in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Thallium Images of Thallium Photos of Thallium Podcasts & MP3s on Thallium Videos on Thallium Evidence Based Medicine Cochrane Collaboration on Thallium Bandolier on Thallium TRIP on Thallium Clinical Trials Ongoing Trials on Thallium at Clinical Trials.gov Trial results on Thallium Clinical Trials on Thallium at Google Guidelines / Policies / Govt US National Guidelines Clearinghouse on Thallium NICE Guidance on Thallium NHS PRODIGY Guidance FDA on Thallium CDC on Thallium Books Books on Thallium News Thallium in the news Be alerted to news on Thallium News trends on Thallium Commentary Blogs on Thallium Definitions Definitions of Thallium Patient Resources / Community Patient resources on Thallium Discussion groups on Thallium Patient Handouts on Thallium Directions to Hospitals Treating Thallium Risk calculators and risk factors for Thallium Healthcare Provider Resources Symptoms of Thallium Causes & Risk Factors for Thallium Diagnostic studies for Thallium Treatment of Thallium Continuing Medical Education (CME) CME Programs on Thallium International Thallium en Espanol Thallium en Francais Business Thallium in the Marketplace Patents on Thallium Experimental / Informatics List of terms related to Thallium Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch. Overview 1 gram of Thallium Thallium (Template:PronEng) is a chemical element with the symbol Tl and atomic number 81. This soft gray malleable poor metal resembles tin but discolors when exposed to air. Thallium is highly toxic and is used in rat poisons and insecticides but since it might also cause cancer (although the United States EPA does not class it as carcinogen), this use has been cut back or eliminated in many countries. It is also used in infrared detectors. It has even been used in some murders, earning the nicknames "The Poisoner's Poison" and "Inheritance powder" (alongside arsenic). Notable characteristics This metal is very soft and malleable and can be cut with a knife. When it is first exposed to air, thallium has a metallic luster but quickly tarnishes with a bluish-gray tinge that resembles lead (it is preserved by keeping it under oil). A heavy layer of oxide builds up on thallium if left in air. In the presence of water, thallium hydroxide is formed. Applications The odorless and tasteless thallium sulfate was widely used in the past as a rat poison and ant killer. In the United States and many other countries this use is no longer allowed due to safety concerns. Other uses: used in the treatment of ringworm and other skin infections. However this use has been limited due to the narrow margin that exists between toxicity and therapeutic benefit. radioactive thallium-201 (half-life of 73 hours) is used for diagnostic purposes in nuclear medicine, particularly in stress tests used for risk stratification in patients with coronary artery disease A(CAD). This isotope of thallium can be generated using a transportable generator which is similar to the technetium cow. The generator contains lead-201 (half life 9.33 hours) which decays by electron capture to the thallium-201. The lead-201 can be produced in a cyclotron by the bombardment of thallium with protons or deuterons by the (p,3n) and (d,4n) reactions. Isotopes Thallium has 25 isotopes which have atomic masses that range from 184 to 210. 203Tl and 205Tl are the only stable isotopes, and 204Tl is the most stable radioisotope, with a half-life of 3.78 years. Thallium-202 (half life 12.23 days) can be made in a cyclotron, while thallium-204 (half life 3.78 years) is made by the neutron activation of stable thallium in a nuclear reactor. Toxicity Thallium and its compounds are very toxic, and should be handled with great care. Contact with skin is dangerous, and adequate ventilation should be provided when melting this metal. Thallium(I) compounds have a high aqueous solubility and are readily absorbed through the skin. Exposure to them should not exceed 0.1 mg per m² of skin in an 8-hour time-weighted average (40-hour work week). Thallium is a suspected human carcinogen. Part of the reason for thallium's high toxicity is that, when present in aqueous solution as the univalent thallium(I) ion (Tl+), it exhibits some similarities with essential alkali metal cations, particularly potassium (as the atomic radius is almost identical). It can thus enter the body via potassium uptake pathways. However, other aspects of thallium's chemistry are very different from that of the alkali metals (e.g., its high affinity for sulfur ligands due to the presence of empty d-orbitals), and so this substitution disrupts many cellular processes (for instance, thallium may attack sulphur-containing proteins such as cysteine residues and ferredoxins). Thallium's toxicity has led to its use (now discontinued in many countries) as a rat and ant poison. Among the distinctive effects of thallium poisoning are loss of hair (which led it to its initial use as a depilatory before its toxicity was properly appreciated) and damage to peripheral nerves (victims may experience a sensation of walking on hot coals). Thallium was once an effective murder weapon before its effects became understood, and an antidote (prussian blue) discovered. Treatment and internal decontamination One of the main methods of removing thallium (both radioactive and normal) from humans is to use Prussian blue, which is a solid ion exchange material which absorbs thallium and releases potassium. The prussian blue is fed by mouth to the person, and it passes through their digestive system and comes out in the stool. References External links WebElements.com — Thallium Toxicity, Thallium NLM Hazardous Substances Databank – Thallium, Elemental [3] ATSDR - ToxFAQs Template:WikiDoc Sources