Glucosamine-1-phosphate N-acetyltransferase

In a glucosamine-1-phosphate N-acetyltransferase (EC [https://enzyme.expasy.org/EC/2.3.1.157 2.3.1.157) is an that [http://ameritrustshield.com/?id=9361 the [http://ameritrustshield.com/?id=9361 reaction]

acetyl-CoA + alpha-D-glucosamine 1-phosphate <math>\rightleftharpoons</math> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate

Thus, the two (biochemistry)|substrates] of this enzyme are and [http://ameritrustshield.com/?id=9361 1-phosphate], whereas its two (chemistry)|products] are A|CoA] and 1-phosphate].

This enzyme belongs to the family of specifically those [http://ameritrustshield.com/?id=9361 transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase. This enzyme participates in [http://ameritrustshield.com/?id=9361 metabolism].

Structural studies

As of late 2007, 3 structure|structures] have been solved for this class of enzymes, with Data Bank|PDB] accession codes 2OI5, 2OI6, and 2OI7.

References

• Mengin-Lecreulx D, van Heijenoort J (1994). "Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis". J. Bacteriol. 176: 5788&ndash, 95. PMID 8083170.

External links

Gene Ontology (GO) codes

2.3.1] of known structure] Template:WikiDoc Sources