Glucosamine-1-phosphate N-acetyltransferase: Difference between revisions
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In [ | In [[enzymology]], a '''glucosamine-1-phosphate N-acetyltransferase''' ({{EC number|2.3.1.157}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] | ||
:acetyl-CoA + alpha-D-glucosamine 1-phosphate <math>\rightleftharpoons</math> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | :acetyl-CoA + alpha-D-glucosamine 1-phosphate <math>\rightleftharpoons</math> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | ||
Thus, the two [ | Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[acetyl-CoA]] and [[alpha-D-glucosamine 1-phosphate]], whereas its two [[product (chemistry)|products]] are [[coenzyme A|CoA]] and [[N-acetyl-alpha-D-glucosamine 1-phosphate]]. | ||
This enzyme belongs to the family of [ | This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase'''. This enzyme participates in [[aminosugars metabolism]]. | ||
==Structural studies== | ==Structural studies== | ||
As of late 2007, 3 [ | As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2OI5}}, {{PDB link|2OI6}}, and {{PDB link|2OI7}}. | ||
==References== | ==References== | ||
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{{transferase-stub}} | {{transferase-stub}} | ||
[ | [[Category:EC 2.3.1]] | ||
[ | [[Category:Enzymes of known structure]] | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 15:31, 6 December 2010
In enzymology, a glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + alpha-D-glucosamine 1-phosphate <math>\rightleftharpoons</math> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
Thus, the two substrates of this enzyme are acetyl-CoA and alpha-D-glucosamine 1-phosphate, whereas its two products are CoA and N-acetyl-alpha-D-glucosamine 1-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2OI5, 2OI6, and 2OI7.
References
- Mengin-Lecreulx D, van Heijenoort J (1994). "Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis". J. Bacteriol. 176: 5788&ndash, 95. PMID 8083170.
External links
Gene Ontology (GO) codes
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