TIMI bleeding criteria: Difference between revisions
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'''TIMI Bleeding Criteria'''<ref name="pmid21670242">{{cite journal| author=Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J et al.| title=Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. | journal=Circulation | year= 2011 | volume= 123 | issue= 23 | pages= 2736-47 | pmid=21670242 | doi=10.1161/CIRCULATIONAHA.110.009449 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21670242 }} </ref> | '''TIMI Bleeding Criteria'''<ref name="pmid21670242">{{cite journal| author=Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J et al.| title=Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. | journal=Circulation | year= 2011 | volume= 123 | issue= 23 | pages= 2736-47 | pmid=21670242 | doi=10.1161/CIRCULATIONAHA.110.009449 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21670242 }} </ref>, <ref name="pmid16253582">{{cite journal| author=Rao SV, O'Grady K, Pieper KS, Granger CB, Newby LK, Van de Werf F et al.| title=Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. | journal=Am J Cardiol | year= 2005 | volume= 96 | issue= 9 | pages= 1200-6 | pmid=16253582 | doi=10.1016/j.amjcard.2005.06.056 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16253582 }} </ref>, <ref name="pmid1906692">{{cite journal| author=Bovill EG, Terrin ML, Stump DC, Berke AD, Frederick M, Collen D et al.| title=Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI), Phase II Trial. | journal=Ann Intern Med | year= 1991 | volume= 115 | issue= 4 | pages= 256-65 | pmid=1906692 | doi= | pmc= | url= }} </ref>, <ref name="pmid17982182">{{cite journal| author=Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S et al.| title=Prasugrel versus clopidogrel in patients with acute coronary syndromes. | journal=N Engl J Med | year= 2007 | volume= 357 | issue= 20 | pages= 2001-15 | pmid=17982182 | doi=10.1056/NEJMoa0706482 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17982182 }} </ref> | ||
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Revision as of 15:54, 17 June 2011
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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TIMI Bleeding Criteria[1], [2], [3], [4]
| “ |
Non-CABG related bleeding
Any intracranial bleeding (excluding microhemorrhages <10 mm evident only on gradient-echo MRI) Clinically overt signs of hemorrhage associated with a drop in hemoglobin of ≥5 g/dL Fatal bleeding (bleeding that directly results in death within 7 d)
Clinically overt (including imaging), resulting in hemoglobin drop of 3 to <5 g/dL Requiring medical attention Any overt sign of hemorrhage that meets one of the following criteria and does not meet criteria for a major or minor bleeding event, as defined above Requiring intervention (medical practitioner-guided medical or surgical treatment to stop or treat bleeding, including temporarily or permanently discontinuing or changing the dose of a medication or study drug) Leading to or prolonging hospitalization Prompting evaluation (leading to an unscheduled visit to a healthcare professional and diagnostic testing, either laboratory or imaging)
Any overt bleeding event that does not meet the criteria above Bleeding in the setting of CABG Fatal bleeding (bleeding that directly results in death) Perioperative intracranial bleeding Reoperation after closure of the sternotomy incision for the purpose of controlling bleeding Transfusion of ≥5 U PRBCs or whole blood within a 48-h period; cell saver transfusion will not be counted in calculations of blood products. Chest tube output >2 L within a 24-h period |
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References
- ↑ Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J; et al. (2011). "Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium". Circulation. 123 (23): 2736–47. doi:10.1161/CIRCULATIONAHA.110.009449. PMID 21670242.
- ↑ Rao SV, O'Grady K, Pieper KS, Granger CB, Newby LK, Van de Werf F; et al. (2005). "Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes". Am J Cardiol. 96 (9): 1200–6. doi:10.1016/j.amjcard.2005.06.056. PMID 16253582.
- ↑ Bovill EG, Terrin ML, Stump DC, Berke AD, Frederick M, Collen D; et al. (1991). "Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI), Phase II Trial". Ann Intern Med. 115 (4): 256–65. PMID 1906692.
- ↑ Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S; et al. (2007). "Prasugrel versus clopidogrel in patients with acute coronary syndromes". N Engl J Med. 357 (20): 2001–15. doi:10.1056/NEJMoa0706482. PMID 17982182.
See also
- Aneurysm
- Coagulation
- Upper gastrointestinal bleed
- Vaginal bleeding
- Intracerebral hemorrhage - bleeding in the brain caused by the rupture of a blood vessel within the head. See also hemorrhagic stroke.
- Subarachnoid hemorrhage (SAH) implies the presence of blood within the subarachnoid space from some pathologic process. The common medical use of the term SAH refers to the nontraumatic types of hemorrhages, usually from rupture of a berry aneurysm or arteriovenous malformation(AVM). The scope of this article is limited to these nontraumatic hemorrhages.
- Intracranial hemorrhage
- Cerebral hemorrhage
- Postpartum hemorrhage
- Hematuria - blood in the urine from urinary bleeding
- Hemoptysis - coughing up blood from the lungs
- Hematemesis - vomiting fresh blood
- Hematochezia - rectal blood
- Exsanguination - death by bleeding
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