PLATO bleeding criteria: Difference between revisions
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PLATO bleeding classification | PLATO bleeding classification | ||
<ref name="pmid15842354">{{cite journal| author=Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis| title=Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | journal=J Thromb Haemost | year= 2005 | volume= 3 | issue= 4 | pages= 692-4 | pmid=15842354 | doi=10.1111/j.1538-7836.2005.01204.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15842354 }} </ref> | <ref name="pmid15842354">{{cite journal| author=Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis| title=Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | journal=J Thromb Haemost | year= 2005 | volume= 3 | issue= 4 | pages= 692-4 | pmid=15842354 | doi=10.1111/j.1538-7836.2005.01204.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15842354 }} </ref> | ||
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Intrapericardial with cardiac tamponade | Intrapericardial with cardiac tamponade | ||
Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery | Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery | ||
Clinically overt or apparent bleeding associated with decrease in hemoglobin | Clinically overt or apparent bleeding associated with decrease in hemoglobin >5 g/dL | ||
Requiring transfusion of | Requiring transfusion of ≥4 U whole blood or PRBCs | ||
*'''Other major''' | *'''Other major''' | ||
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PLATO bleeding classification
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Fatal Intracranial Intrapericardial with cardiac tamponade Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery Clinically overt or apparent bleeding associated with decrease in hemoglobin >5 g/dL Requiring transfusion of ≥4 U whole blood or PRBCs
Significantly disabling (eg, intraocular with permanent vision loss) Associated drop in hemoglobin of 3 to 5 g/dL Requiring transfusion of 2 to 3 U whole blood or PRBCs
Any one of the above criteria
Requiring medical intervention to stop or treat bleeding (eg, epistaxis requiring visit to medical facility for packing)
All others (eg, bruising, bleeding gums, oozing from injection sites) not requiring intervention or treatment |
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- ↑ Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2005). "Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients". J Thromb Haemost. 3 (4): 692–4. doi:10.1111/j.1538-7836.2005.01204.x. PMID 15842354.
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