Spinal Muscular atrophy Molecular Biology: Difference between revisions
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New page: {{Spinal Muscular Atrophy}} {{CMG}} __NOTOC__ {{Editor Help}} SMN (survival motor neuron)gene produces SMN protein. This protein is ubiquitously found in all cells (located in both the... |
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SMN (survival motor neuron)gene produces SMN protein. This protein is ubiquitously found in all cells (located in both the cytoplasm and in the nucleus). | |||
SMN ([[survival motor neuron]])gene produces SMN protein. This protein is ubiquitously found in all cells (located in both the cytoplasm and in the nucleus). | |||
The main function that is found to be associated with them are as follows | The main function that is found to be associated with them are as follows | ||
* They are components of spliceosome, involved in pre-m-RNA splicing | * They are components of [['''spliceosome''']], involved in [[pre-m-RNA]] [[splicing]] <ref name="pmid17761654">{{cite journal| author=Kolb SJ, Battle DJ, Dreyfuss G| title=Molecular functions of the SMN complex. | journal=J Child Neurol | year= 2007 | volume= 22 | issue= 8 | pages= 990-4 | pmid=17761654 | doi=10.1177/0883073807305666 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17761654 }} </ref> | ||
* Involved in actin cytoskeletal dynamics (Bowerman 2009 which is involved in motor axon pathfinding | * Involved in '''[[actin cytoskeletal]]''' dynamics (Bowerman 2009 which is involved in motor axon pathfinding | ||
* Appears to be involved in maintaining structural and physiological integrity of neuromuscular junction Rossoll 2009 | * Appears to be involved in maintaining structural and physiological integrity of [['''neuromuscular junction''']] <ref name="pmid19343312">{{cite journal| author=Rossoll W, Bassell GJ| title=Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes. | journal=Results Probl Cell Differ | year= 2009 | volume= 48 | issue= | pages= 289-326 | pmid=19343312 | doi=10.1007/400_2009_4 | pmc= | url= }} </ref> | ||
==References== | ==References== | ||
Revision as of 14:22, 25 June 2011
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SMN (survival motor neuron)gene produces SMN protein. This protein is ubiquitously found in all cells (located in both the cytoplasm and in the nucleus).
The main function that is found to be associated with them are as follows
- They are components of '''spliceosome''', involved in pre-m-RNA splicing [1]
- Involved in actin cytoskeletal dynamics (Bowerman 2009 which is involved in motor axon pathfinding
- Appears to be involved in maintaining structural and physiological integrity of '''neuromuscular junction''' [2]
References
- ↑ Kolb SJ, Battle DJ, Dreyfuss G (2007). "Molecular functions of the SMN complex". J Child Neurol. 22 (8): 990–4. doi:10.1177/0883073807305666. PMID 17761654.
- ↑ Rossoll W, Bassell GJ (2009). "Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes". Results Probl Cell Differ. 48: 289–326. doi:10.1007/400_2009_4. PMID 19343312.